Geographically Weighted Cox Regression for Prostate Cancer Survival Data in Louisiana

Abstract Background Previous work found higher serum 25-hydroxyvitamin D (25(OH)D) [circulating form of vitamin D] concentrations at diagnosis were associated with longer survival in patients with ovarian cancer (OvCa). There was no evidence for an association with 25(OH)D after primary treatment, but power was limited. Our aim was to reassess this association in a larger sample, including measures collected during treatment and using techniques to deseasonalise 25(OH)D. Methods Participants were diagnosed between 2002-2006 and 2012-2015 from the Australian Ovarian Cancer Study (AOCS) and the Ovarian Cancer, Prognosis and Lifestyle (OPAL) study, respectively. 25(OH)D concentrations were available for 676 at diagnosis (AOCS), 805 during treatment (AOCS:208; OPAL:597) and 861 after completion of primary treatment and before recurrence (AOCS:342; OPAL:519); 1006 AOCS samples were included in the previous analysis. Sociodemographic, diet and lifestyle data came from questionnaires self-completed at recruitment, and clinical/survival data from medical records, supplemented with National Death Index linkage. We will use Cox regression and non-parametric models to examine associations with survival. Results Median 25(OH)D concentrations were lowest during treatment, intermediate at diagnosis and highest after treatment (AOCS 51, 64, and 71 nmol/L, respectively). 5-year survival was 50% in AOCS and 59% in OPAL. Updated survival results will be presented. Conclusions If the association is confirmed in this updated analysis, then increasing vitamin D concentrations may provide a way to improve survival following OvCa. Key messages Higher circulating vitamin D concentrations may improve survival in OvCa.

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Extended Cox model for breast cancer survival data using Bayesian approach: A case study

Journal of Physics Conference Series ◽

10.1088/1742-6596/1341/9/092013 ◽

2019 ◽

Vol 1341 ◽

pp. 092013

Author(s):

R Arsyad ◽

S A Thamrin ◽

A K Jaya

Keyword(s):

Breast Cancer ◽

Bayesian Approach ◽

Survival Data ◽

Cancer Survival ◽

Cox Model ◽

Breast Cancer Survival ◽

Cancer Survival Data ◽

Extended Cox Model

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Cancer survival in Cali, Colombia: A population-based study, 1995-2004

Colombia Medica ◽

10.25100/cm.v45i3.1525 ◽

2014 ◽

pp. 110-116 ◽

Cited By ~ 7

Author(s):

Luis Eduardo Bravo ◽

Luz Stella García ◽

Paola Andrea Collazos

Keyword(s):

Prostate Cancer ◽

Lung Cancer ◽

Stomach Cancer ◽

Survival Data ◽

Cancer Survival ◽

Relative Survival ◽

Population Based ◽

Cervix Uteri ◽

Limited Information ◽

Cure Fraction

Background: There is limited information on population-based cancer survival data in Latin America. Objetive: To obtain estimates of survival for some cancers recognized as a public health priority in Colombia using data from the Cancer Registry of Cali for 1995-2004. Methods: All cancer cases for residents of Cali were included for the following sites: breast (3,984), cervix uteri (2,469), prostate (3,999), stomach (3,442) and lung (2,170). Five-year relative survival estimates were calculated using the approach described by Estève. Results: Five-year relative survival was 79% in patients with prostate cancer and 68% and 60% in women with breast or cervix uteri cancer, respectively. The cure fraction was 6% in subjects with lung cancer and 15% in those with stomach cancer. The probability of dying from breast or prostate cancer in people in the lower socio-economic strata (SES) was 1.8 and 2.6 times greater, respectively, when compared to upper SES, p <0.001. Excess mortality associated with cancer was independent of age in prostate or breast cancer. After adjusting for age, sex and SES, the risk of dying from breast, cervix uteri, prostate and lung cancer during the 2000-2004 period decreased 19%, 13%, 48% and 16%, respectively, when compared with the period of 1995-1999. There was no change in the prognosis for patients with stomach cancer. Conclusions: Survival for some kinds of cancer improved through the 1995-2004 period, however health care programs for cancer patients in Cali are inequitable. People from lower SES are the most vulnerable and the least likely to survive.

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