To Be or Not to Be Patent: The Relationship Between Migraine and Patent Foramen Ovale

2015 ◽  
Vol 55 (7) ◽  
pp. 934-942 ◽  
Author(s):  
Nihan Kahya Eren ◽  
Nazlı G. Bülbül ◽  
Selcen Yakar Tülüce ◽  
Cem Nazlı ◽  
Yeşim Beckmann
Keyword(s):  
Patent Foramen Ovale ◽  
Foramen Ovale ◽  
The Relationship

Patent Foramen Ovale, the Role of Antiplatelet Therapy Alone or Anticoagulant Therapy Alone Versus Device Closure for Cryptogenic Stroke: A Review of the Literature and Current Recommendations

2020 ◽  
Vol 18 (2) ◽  
pp. 135-150
Author(s):  
Harsha S. Nagarajarao ◽  
Chandra P. Ojha ◽  
Archana Kedar ◽  
Debabrata Mukherjee
Keyword(s):  
Patent Foramen Ovale ◽  
Cryptogenic Stroke ◽  
Narrow Channel ◽  
Paradoxical Embolism ◽  
Current Evidence ◽  
Foramen Ovale ◽  
The Right ◽  
The Relationship ◽  
Current Guidelines

: Cryptogenic stroke and its relation to the Patent Foramen Ovale (PFO) is a long-debated topic. Recent clinical trials have unequivocally established the relationship between cryptogenic strokes and paradoxical embolism across the PFO. This slit-like communication exists in everyone before birth, but most often closes shortly after birth. PFO may persist as a narrow channel of communication between the right and left atria in approximately 25-27% of adults. : In this review, we examine the clinical relevance of the PFO with analysis of the latest trials evaluating catheter-based closure of PFO’s for cryptogenic stroke. We also review the current evidence examining the use of antiplatelet medications versus anticoagulants for stroke prevention in those patients with PFO who do not qualify for closure per current guidelines.

Population-Based Study of the Relationship Between Patent Foramen Ovale and Cerebrovascular Ischemic Events

2006 ◽  
Vol 81 (5) ◽  
pp. 602-608 ◽  
Author(s):  
George W. Petty ◽  
Bijoy K. Khandheria ◽  
Irene Meissner ◽  
Jack P. Whisnant ◽  
Walter A. Rocca ◽  
...  
Keyword(s):  
Patent Foramen Ovale ◽  
Population Based ◽  
Foramen Ovale ◽  
Population Based Study ◽  
The Relationship ◽  
Ischemic Events

scholarly journals A Study on the Relationship Between Patent Foramen Ovale and White Matter Lesions in Migraine Patients

2021 ◽  
Author(s):  
Junyan Huo ◽  
Mengxia Wan ◽  
Nan Li ◽  
Juan Wang ◽  
Xiao Cai ◽  
...  
Keyword(s):  
White Matter ◽  
Transcranial Doppler ◽  
Patent Foramen Ovale ◽  
White Matter Lesions ◽  
Primary Headache ◽  
Transcranial Doppler Ultrasound ◽  
Foramen Ovale ◽  
Significant Difference ◽  
The Difference ◽  
The Relationship

Abstract Background Migraine is a common clinical primary headache with unclear aetiology. In recent years, studies have shown that migraine is related to patent foramen ovale, and some patients with migraine have white matter lesions. However, the relationship among the three is unclear.Objective To explore the characteristics of white matter lesions (WMLs) in migraine patients with patent foramen ovale and to predict the occurrence of patent foramen ovale through magnetic resonance imaging (MRI) characteristics in patients with migraine.Methods Seventy-seven patients clinically diagnosed with migraine were examined by transcranial Doppler ultrasound (cTCD) and MRI. The patients were grouped according to the presence of WMLs, with matching by age, sex, hypertension, diabetes, PFO and other characteristic data. We observed the MRI fluid attenuation inversion recovery sequence (FLAIR) image and compared and analysed the difference in WMLs between the PFO-positive group and the PFO-negative group.Results There were 42 cases and 35 cases of migraine with and without WMLs, respectively. A statistically significant difference in near-cortical WMLs with PFO in migraine patients was observed (P=0.001). Logistic regression analysis adjusted by age, sex, hypertension and diabetes identified PFO status as the sole determinant for the presence of near-cortical WMLs (OR = 0.14; 95%CI 0.045–0.421; p < 0.001)Conclusion Near-cortical white matter lesions in migraine patients are related to PFO. Transcranial Doppler ultrasonography may reveal more PFO in patients with migraine and near-cortical WMLs.

scholarly journals Patent Foramen Ovale and Cryptogenic Stroke: Challenges in Diagnosis and Management

2021 ◽  
Vol 42 (3) ◽  
Author(s):  
Dhanang Ali Yafi ◽  
Azmi Azmi
Keyword(s):  
Patent Foramen Ovale ◽  
Adult Population ◽  
Management Strategies ◽  
Cryptogenic Stroke ◽  
Paradoxical Embolism ◽  
Foramen Ovale ◽  
Arterial Circulation ◽  
Systemic Embolization ◽  
The Relationship ◽  
Pfo Closure

A patent foramen ovale (PFO) is a common disorder that affects between 20-34% of the adult population. This condition is a benign finding for most people. However, In some the PFO can open widely and enabling paradoxical embolism to transit from venous to arterial circulation, which is associated with stroke and systemic embolization. There are still unclear to date regarding the effectiveness of pharmacological anticoagulant therapy, defined as antithrombin or antiplatelet therapy, which has proven to be more beneficial for patients with PFO and cryptogenic stroke. In addition, surgical and transcutaneous PFO closure has been proposed for secondary prevention of stroke in patients with cryptogenic stroke with PFO. Both catheter-based and surgical modes of closure have been shown to reduce the incidence of subsequent embolism substantially. This review will discuss the evidence regarding the relationship between PFO and cryptogenic stroke and decision making for management strategies.

scholarly journals Patent foramen ovale and migraine: What is the relationship between the two?

2013 ◽  
Vol 61 (4) ◽  
pp. 256-259 ◽  
Author(s):  
Sivarani Sathasivam ◽  
Sivakumar Sathasivam
Keyword(s):  
Patent Foramen Ovale ◽  
Foramen Ovale ◽  
The Relationship

Correlation or causation: Untangling the relationship between patent foramen ovale and migraine

2007 ◽  
Vol 9 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Eric Adler ◽  
Barry Love ◽  
Steve Giovannone ◽  
Frank Volpicelli ◽  
Martin E. Goldman
Keyword(s):  
Patent Foramen Ovale ◽  
Foramen Ovale ◽  
The Relationship

scholarly journals Doppler ultrasound assessment of minor atrial septal defects in patients with paradoxical embolism

2021 ◽  
Vol 15 (4) ◽  
pp. 86-92
Author(s):  
Alina R. Karshieva ◽  
Andrey O. Chechetkin ◽  
Anastasia V. Belopasova ◽  
Larisa A. Dobrynina
Keyword(s):  
Patent Foramen Ovale ◽  
Septal Defect ◽  
Paradoxical Embolism ◽  
Foramen Ovale ◽  
Septal Defects ◽  
Clinical Observations ◽  
Scientific Papers ◽  
Ultrasound Assessment ◽  
The Relationship ◽  
The Brain

Minor atrial septal defect (ASD) may be one of the pathways of paradoxical embolism in the brain. Few scientific papers have investigated the relationship between ASD (excluding patent foramen ovale) and the occurrence of ischemic stroke. There is no definite opinion as to how functionally important such shunts are and how the shunt changes with age. The review analyzes modern ideas about the probability of paradoxical embolism in small ASDs from the viewpoint of pathophysiology, and also demonstrates the technological capabilities of assessing the functional significance of such shunts based on our own clinical observations.

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