Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation

2020 ◽  
Vol 77 (3) ◽  
pp. 492-502
Author(s):  
Yuya Yamashiro ◽  
Tsuyoshi Saito ◽  
Takuo Hayashi ◽  
Takashi Murakami ◽  
Yuka Yanai ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features

Relation of glypican-3 and E-cadherin expressions to clinicopathological features and prognosis of mucinous and non-mucinous colorectal adenocarcinoma

Tumor Biology ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 4671-4679 ◽  
Author(s):  
Abd Al-Rahman Mohammad Foda ◽  
Mie Ali Mohammad ◽  
Azza Abdel-Aziz ◽  
Amira Kamal El-Hawary
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
E Cadherin

Colorectal adenocarcinoma with mucinous component: relation of MMP-13, EGFR, and E-cadherin expressions to clinicopathological features and prognosis

Apmis ◽  
2015 ◽  
Vol 123 (6) ◽  
pp. 502-508 ◽  
Author(s):  
Abd Al-Rahman Mohammad Foda ◽  
Amira Kamal El-Hawary ◽  
Azza Abdel Aziz
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
Mucinous Component ◽  
E Cadherin ◽  
Component Relation

scholarly journals Clinicopathological features and the value of differential Cytokeratin 7 and 20 expression in resolving diagnostic dilemmas of ovarian involvement by colorectal adenocarcinoma and vice-versa

2008 ◽  
Vol 3 (1) ◽  
pp. 39 ◽  
Author(s):  
Bharat Rekhi ◽  
Sophia George ◽  
Bhulaxmi Madur ◽  
RF Chinoy ◽  
Rajesh Dikshit ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
Cytokeratin 7 ◽  
Ovarian Involvement

Mucinous colorectal adenocarcinoma: relation of glypican-3 and e-cadherin expressions to clinicopathological features and prognosis

Pathology ◽  
2016 ◽  
Vol 48 ◽  
pp. S124-S125
Author(s):  
Abd Al-Rahman Mohammad Foda ◽  
Mie Ali Mohammad ◽  
Azza Abdel-Aziz ◽  
Amira Kamal El-Hawary
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
E Cadherin

hTERT expression in colorectal adenocarcinoma: correlations with p21, p53 expressions and clinicopathological features

2008 ◽  
Vol 23 (6) ◽  
pp. 587-594 ◽  
Author(s):  
Alfred King-Yin Lam ◽  
Kate Ong ◽  
Yik-Hong Ho
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
Htert Expression

scholarly journals Clinical significance of mucinous component in colorectal adenocarcinoma: a propensity score-matched study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chuanwang Yan ◽  
Hui Yang ◽  
Lili Chen ◽  
Ran Liu ◽  
Wei Shang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Propensity Score ◽  
Clinical Significance ◽  
Roc Curve ◽  
Colorectal Adenocarcinoma ◽  
Univariate Analysis ◽  
Multivariable Analysis ◽  
Clinicopathological Features ◽  
Mucinous Component ◽  
Before And After

Abstract Background This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. Propensity score matching (PSM) was performed according to a 1:1 ratio. Receiver-operating characteristic (ROC) curve was used to identify the optimal cut-off value of MC ratio for prognostic prediction. The clinicopathological features and 3-year overall survival (OS) of AC patients, mucinous adenocarcinoma (MAC) (MC > 50%) patients, and ACMC (1–50%) patients were compared before and after matching. Multivariable analysis was used for analyzing independent risk factors related to prognosis. Results A total of 532 patients were enrolled in this study. Patients with AC, MAC, and ACMC (1–50%) exhibited different clinicopathological features. However, their 3-year OS rates were similar (82.00% vs. 74.11% vs. 81.48%, P = 0.38). After matching, ROC curve determined 70% as the optimal cut-off value. And patients with ACMC > 70% had a much poorer 3-year OS compared with ACMC (1–70%) patients and AC patients (47.37% vs. 86.15% vs. 79.76%, P < 0.001). In addition, ACMC > 70% was revealed as a risk factor for poor survival in univariate analysis (HR = 1.643, 95%CI = 1.025–2.635, P = 0.039), though not an independent risk factor in multivariable analysis (HR = 1.550, 95%CI = 0.958–2.507, P = 0.074). Conclusions MAC is usually diagnosed at an advanced stage. MAC has a similar survival with AC and ACMC (1–50%) patients before and after matching. Patients with ACMC > 70% exhibited a much poorer OS, and should be given more clinical attention.

scholarly journals Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Nadia Ben Jemii ◽  
Haifa Tounsi-Kettiti ◽  
Hamza Yaiche ◽  
Najla Mezghanni ◽  
Amira Jaballah Gabteni ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Potential Role ◽  
Colorectal Adenocarcinoma ◽  
Growth Factor Receptor ◽  
Clinicopathological Features ◽  
Tumor Diameter ◽  
Wild Type ◽  
Normal Colon ◽  
Ras Status

Abstract Background Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibitors emerged in the therapy of diverse cancers. In colorectal cancer, the commonly used therapy is anti-epithelial growth factor receptor (EGFR). However, both RAS mutated and a subgroup of RAS wild type patients resist to such therapy. The aim of this study is to investigate PDGFRα protein expression and mutational status in colorectal adenocarcinoma and their association with clinicopathological features and molecular RAS status to provide useful information for the identification of an effective biomarker that might be implicated in prognosis and treatment prediction. Methods Our study enrolled 103 formalin fixed paraffin-embedded (FFPE) colorectal adenocarcinoma. PDGFRα expression was investigated by immunohistochemistry (IHC). Hotspot exon 18 of PDGFRA was studied by PCR followed by Sanger sequencing and RAS status was determined by real time quantitative PCR. Thirteen normal colon tissues were used as negative controls. Results PDGFRα staining was detected in the cytoplasm of all tissues. Low expression was observed in all normal colon mucosa. In adenocarcinoma, 45% (45/100) of cases showed PDGFRα overexpression. This overexpression was significantly associated with mutations in exon 18 (P = 0.024), RAS wild type status (P < 10–3), tumor diameter (P = 0.048), whereas there was no association with tumor side (P = 0.13) and other clinicopathological features. Conclusion Overexpression of PDGFRα in adenocarcinoma suggests its potential role in tumor cells growth and invasion. The association between PDGFRα overexpression in both tumor and stromal adenocarcinoma cells with RAS wild type status suggests its potential role in anti-EGFR therapy resistance and the relevance of using it as specific or adjuvant therapeutic target.

Colorectal adenocarcinoma with mucinous activity: relation of EGFR, MMP-13 and E-cadherin expressions to clinicopathological features and prognosis

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S80-S81
Author(s):  
Abd Al-Rahman Mohammad Foda ◽  
Azza Abdel-Aziz ◽  
Amira Kamal El-Hawary ◽  
Ali Hosni ◽  
Khaled Refaat Zalata ◽  
...  
Keyword(s):  
Colorectal Adenocarcinoma ◽  
Clinicopathological Features ◽  
E Cadherin
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