scholarly journals Metaplastic breast cancer is heterogeneous; treatment should be personalized

2021 ◽  
Vol 79 (S1) ◽  
pp. 11-11



Author(s):  
Ga Young Yoon ◽  
Joo Hee Cha ◽  
Hak Hee Kim ◽  
Hee Jung Shin ◽  
Eun Young Chae ◽  
...  

Background: Metaplastic breast cancer (MC) is a rare disease, thus it is difficult to study its clinical outcomes. Objective: To investigate whether any clinicopathological or imaging features were associated with clinical outcome in MC. Methods: We retrospectively evaluated the clinicopathological and imaging findings, and the clinical outcomes of seventy-two pathologically confirmed MCs. We then compared these parameters between triple-negative (TNMC) and non-TNMCs (NTNMC). Results: Oval or round shape, and not-circumscribed margin were the most common findings on mammography, ultrasound (US), and magnetic resonance imaging (MRI). It was mostly a mass without calcification on mammography, and revealed complex or hypoechoic echotexture, and posterior acoustic enhancement on US, and rim enhancement, wash-out kinetics, peritumoral edema, and intratumoral necrosis on MRI. Of all 72, 64 were TNMCs, and eight were NTNMCs. Clinicopathological and imaging findings were similar between the two groups, except that MRI showed peritumoral edema more frequently in TNMCs than NTNMCs (p=0.045). There were 21 recurrences and 13 deaths. Multivariable analysis showed that larger tumor size and co-existing DCIS were significantly predictive of Disease free survival (DFS), and larger tumor size and neoadjuvant chemotherapy were significantly predictive of overall survival (OS). Conclusion: MC showed characteristic imaging findings, and some variables associated with survival outcome may help to predict prognosis.



2018 ◽  
Vol 247 (2) ◽  
pp. 214-227 ◽  
Author(s):  
Amy Ellen McCart Reed ◽  
Emarene Kalaw ◽  
Katia Nones ◽  
Mark Bettington ◽  
Malcolm Lim ◽  
...  


2018 ◽  
Vol 22 (4) ◽  
pp. 45-51
Author(s):  
Alya S. Binmahfouz

Metaplastic breast cancer is rare, representing < 5% of breast cancer (only eight cases have been reported so far). We present here a 42-year-old female complaining of a painless lump in the right breast for the previous two months. Physical examination revealed a palpable mass. Lumpectomy was performed and histopathologic examination revealed metaplastic breast carcinoma with foci of chondrosarcoma. The patient received adjuvant radiation therapy and chemotherapy and is currently following up as an outpatient. We also discuss diff erentimaging diagnostic features of this specifi c type of breast cancer using mammography, ultrasonography, and magnetic resonance imaging.



2018 ◽  
Vol 167 (2) ◽  
pp. 605-606
Author(s):  
Muhammad Asaduzzaman ◽  
Stephanie Constantinou ◽  
Haoxiang Min ◽  
John Gallon ◽  
Meng-Lay Lin ◽  
...  


2018 ◽  
Vol 2 ◽  
pp. AB195-AB195
Author(s):  
Niamh Siobhan Buckley ◽  
Syer Ree Tee ◽  
Anne O’Doherty ◽  
Cecilly Quinn ◽  
Jane Rothwell ◽  
...  


2018 ◽  
Vol 173 (2) ◽  
pp. 329-341 ◽  
Author(s):  
Xuexin He ◽  
Jiali Ji ◽  
Rongrong Dong ◽  
Hong Liu ◽  
Xiaolan Dai ◽  
...  


2019 ◽  
Vol 93 ◽  
pp. 97-102 ◽  
Author(s):  
Klaus Jürgen Schmitz ◽  
Matthias Losch ◽  
Abbas Agaimy


2019 ◽  
Vol 9 ◽  
Author(s):  
Jun Wang ◽  
Wen-Wen Zhang ◽  
Chen-Lu Lian ◽  
Jia-Yuan Sun ◽  
Zhen-Yu He ◽  
...  


BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jasmine A. McQuerry ◽  
David F. Jenkins ◽  
Susan E. Yost ◽  
Yuqing Zhang ◽  
Daniel Schmolze ◽  
...  


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