Comparative effectiveness of pathologic techniques to improve lymph node yield from colorectal cancer specimens. A systematic review and network meta‐analysis

2021 ◽  
Author(s):  
Christos Athanasiou ◽  
Fehmi Hafiz ◽  
Alexia Tsigka ◽  
James Hernon ◽  
Adam Stearns
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Lymph Node ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Node Yield

Lymph node yield during surgery after neoadjuvant therapy compared to surgery without neoadjuvant therapy in patients with esophageal, gastric, pancreatic, or rectal carcinoma: systematic review and meta-analysis (Preprint)

2021 ◽  
Author(s):  
Ulrich Ronellenfitsch ◽  
Nika Maximov ◽  
Juliane Friedrichs ◽  
Jorg Kleeff
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Neoadjuvant Therapy ◽  
Meta Analysis ◽  
Neoadjuvant Treatment ◽  
Surrogate Marker ◽  
Lymph Node Yield ◽  
Gastrointestinal Carcinomas ◽  
Node Yield

BACKGROUND The lymph node yield is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas and a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield. OBJECTIVE This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy. METHODS Studies comparing oncological resection of esophageal, stomach, pancreatic and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in the electronic databases PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include number of harvested metastatic lymph nodes, operation time, postoperative complications, pTNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy as well as in defined subgroups (neoadjuvant chemotherapy, neoadjuvant radiotherapy, neoadjuvant chemoradiotherapy, and esophageal, gastric, pancreatic, and rectal cancer) will be compared. RESULTS As of October 2021, we started with the data collection. CONCLUSIONS This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy. CLINICALTRIAL This systematic review is registered at PROSPERO, ID: 218459.

scholarly journals Lymph node yield during surgery after neoadjuvant therapy compared to surgery without neoadjuvant therapy in patients with esophageal, gastric, pancreatic, or rectal carcinoma: systematic review and meta-analysis

2021 ◽  
Author(s):  
Ulrich Ronellenfitsch ◽  
Nika Maximov ◽  
Juliane Friedrichs ◽  
Jörg Kleeff
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Neoadjuvant Therapy ◽  
Rectal Carcinoma ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Gastrointestinal Carcinomas ◽  
Node Yield

Abstract Background: The lymph node yield is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas and a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield. This systematic review and meta-analysis intents to summarize the available evidence on the topic.Methods: Studies comparing oncological resection of esophageal, stomach, pancreatic and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in the electronic databases PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include number of harvested metastatic lymph nodes, operation time, postoperative complications, pTNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy as well as in defined subgroups (neoadjuvant chemotherapy, neoadjuvant radiotherapy, neoadjuvant chemoradiotherapy, and esophageal, gastric, pancreatic, and rectal cancer) will be compared Discussion: This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy.Systematic review registration: This systematic review has been submitted for registration at PROSPERO, ID: 218459.

scholarly journals Does the lymph node yield affect survival in patients with esophageal cancer receiving neoadjuvant therapy plus esophagectomy? A systematic review and updated meta-analysis

2020 ◽  
Vol 25 ◽  
pp. 100431
Author(s):  
Donglai Chen ◽  
Yiming Mao ◽  
Yuhang Xue ◽  
Yonghua Sang ◽  
Desen Liu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Esophageal Cancer ◽  
Lymph Node ◽  
Neoadjuvant Therapy ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Node Yield

scholarly journals Lymph node yield after rectal resection in patients treated with neoadjuvant radiation for rectal cancer: A systematic review and meta-analysis

2017 ◽  
Vol 72 ◽  
pp. 84-94 ◽  
Author(s):  
Robert Mechera ◽  
Tibor Schuster ◽  
Robert Rosenberg ◽  
Benjamin Speich
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Lymph Node ◽  
Rectal Resection ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Node Yield

scholarly journals Role of lymph node yield and lymph node ratio in predicting outcomes in non-metastatic colorectal cancer

BJS Open ◽  
2018 ◽  
Vol 3 (1) ◽  
pp. 95-105 ◽  
Author(s):  
C. H. A. Lee ◽  
S. Wilkins ◽  
K. Oliva ◽  
M. P. Staples ◽  
P. J. McMurrick
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Metastatic Colorectal Cancer ◽  
Lymph Node Ratio ◽  
Lymph Node Yield ◽  
Node Ratio ◽  
Node Yield

P13. Lymph node yield following colorectal cancer resection: does surgical approach matter?

2015 ◽  
Vol 41 (11) ◽  
pp. S272-S273
Author(s):  
Sreelakshmi Mallappa ◽  
Shyamala Fernandez ◽  
Faris Kubba ◽  
Mariasoosai Pathmarajah
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Surgical Approach ◽  
Lymph Node Yield ◽  
Cancer Resection ◽  
Colorectal Cancer Resection ◽  
Node Yield
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