Behaviour of human dental pulp cells cultured in a collagen hydrogel scaffold cross-linked with cinnamaldehyde

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pp. 58-66 ◽  
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Y. C. Hwang ◽  
V. Rosa ◽  
K. W. Lee ◽  
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pp. 76-84 ◽  
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Eun-su Lim ◽  
Myung-Jin Lim ◽  
Kyung-San Min ◽  
Young-Sun Kwon ◽  
Yun-Chan Hwang ◽  
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Vol 21 (9) ◽  
pp. 2827-2839 ◽  
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Hebert Luís Rosseto ◽  
Débora Salles Scheffel ◽  
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Claudia Huck ◽  
...  

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Tianjiao Jiang ◽  
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Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2449
Author(s):  
Beata Kaczmarek-Szczepańska ◽  
Olha Mazur ◽  
Marta Michalska-Sionkowska ◽  
Krzysztof Łukowicz ◽  
Anna Maria Osyczka

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.


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