Does tobacco smoking predispose to apical periodontitis and endodontic treatment need? A systematic review and meta‐analysis

Abstract Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and meta-analysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms “Periapical Periodontitis,” “Periapical Abscess,” “Polymorphism, Genetic,” and “Polymorphism, Single Nucleotide” were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.

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Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis

BMC Public Health ◽

10.1186/s12889-018-6319-3 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 17

Author(s):

Pravesh Kumar Bundhun ◽

Girish Janoo ◽

Akash Bhurtu ◽

Abhishek Rishikesh Teeluck ◽

Mohammad Zafooruddin Sani Soogund ◽

...

Keyword(s):

Systematic Review ◽

Tobacco Smoking ◽

Semen Quality ◽

Meta Analysis

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Evaluating Smoking Cessation Interventions and Cessation Rates in Cancer Patients: A Systematic Review and Meta-Analysis

ISRN Oncology ◽

10.5402/2011/849023 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 15

Author(s):

Smriti Nayan ◽

Michael K. Gupta ◽

Doron D. Sommer

Keyword(s):

Systematic Review ◽

Smoking Cessation ◽

Usual Care ◽

Cancer Patients ◽

Tobacco Smoking ◽

Treatment Plan ◽

Meta Analysis ◽

Cochrane Library ◽

Comprehensive Treatment ◽

Oncology Patient

Background. Tobacco smoking cessation interventions in the oncology population are an important part of comprehensive treatment plan. Objectives. To evaluate through a systematic review smoking cessation interventions and cessation rates in cancer patients. Search Strategy. The literature was searched using Medline, EMBASE, and the Cochrane Library (inception to November 2010) by three independent review authors. Selection Criteria. Studies were included if tobacco smoking cessation interventions were evaluated and patients were randomized to usual care or an intervention. The primary outcome measure was cessation rates. Data Collection and Analysis. Two authors extracted data independently for each paper, with disagreements resolved by consensus. Main Results. The systematic review found eight RCTs investigating smoking cessation interventions in the oncology patient population. Pooled relative risks were calculated from two groups of RCTs of smoking cessation interventions based on followup duration. In both groups, the pooled relative risk did not suggest a statistically significant improvement in tobacco cessation compared to usual care. Conclusions. Our review demonstrates that recent interventions in the last decade which are a combination of non-pharmacological and pharmacological approaches yield a statistically significant improvement in smoking cessation rates compared to usual care.

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