scholarly journals Leukotriene B4-leukotriene B4receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8+T cells

Immunology ◽  
2015 ◽  
Vol 146 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Jiaoyan Lv ◽  
Linlin Zou ◽  
Lina Zhao ◽  
Wei Yang ◽  
Yingluo Xiong ◽  
...  
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Cd8 T Cells ◽  
Leukotriene B4 ◽  
Skin Homing

scholarly journals Nickel-Specific CD4+ and CD8+ T Cells Display Distinct Migratory Responses to Chemokines Produced During Allergic Contact Dermatitis

2002 ◽  
Vol 118 (6) ◽  
pp. 1052-1058 ◽  
Author(s):  
Silvia Sebastiani ◽  
Cristina Albanesi ◽  
Francesca Nasorri ◽  
Giampiero Girolomoni ◽  
Andrea Cavani
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Cd8 T Cells ◽  
Allergic Contact

scholarly journals Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells

2017 ◽  
Vol 91 (19) ◽  
Author(s):  
Michael T. Hensel ◽  
Tao Peng ◽  
Anqi Cheng ◽  
Stephen C. De Rosa ◽  
Anna Wald ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Cell Surface ◽  
Cd8 T Cells ◽  
Chemokine Receptors ◽  
Mrna Levels ◽  
Skin Homing ◽  
Simplex Virus

ABSTRACT Herpes simplex virus (HSV) infection is restricted to epithelial cells and neurons and is controlled by CD8 T cells. These cells both traffic to epithelial sites of recurrent lytic infection and to ganglia and persist at the dermal-epidermal junction for up to 12 weeks after lesion resolution. We previously showed that cutaneous lymphocyte-associated antigen (CLA), a functional E-selectin ligand (ESL), is selectively expressed on circulating HSV-2-specific CD8 T cells. CLA/ESL mediates adhesion of T cells to inflamed vascular endothelium. Later stages in T-cell homing involve chemokines (Ch) and lymphocyte chemokine receptors (ChR) for vascular wall arrest and diapedesis. Several candidate ChR have been implicated in skin homing. We measured cell surface ChR on HSV-specific human peripheral blood CD8 T cells and extended our studies to HSV-1. We observed preferential cell surface expression of CCR10 and CXCR3 by HSV-specific CD8 T cells compared to CD8 T cells specific for control viruses, Epstein-Barr virus (EBV) and cytomegalovirus (CMV), and compared to bulk memory CD8 T cells. CXCR3 ligand mRNA levels were selectively increased in skin biopsy specimens from persons with recurrent HSV-2, while the mRNA levels of the CCR10 ligand CCL27 were equivalent in lesion and control skin. Our data are consistent with a model in which CCL27 drives baseline recruitment of HSV-specific CD8 T cells expressing CCR10, while interferon-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation. IMPORTANCE HSV-2 causes very localized recurrent infections in the skin and genital mucosa. Virus-specific CD8 T cells home to the site of recurrent infection and participate in viral clearance. The exit of T cells from the blood involves the use of chemokine receptors on the T-cell surface and chemokines that are present in infected tissue. In this study, circulating HSV-2-specific CD8 T cells were identified using specific fluorescent tetramer reagents, and their expression of several candidate skin-homing-associated chemokine receptors was measured using flow cytometry. We found that two chemokine receptors, CXCR3 and CCR10, are upregulated on HSV-specific CD8 T cells in blood. The chemokines corresponding to these receptors are also expressed in infected tissues. Vaccine strategies to prime CD8 T cells to home to HSV lesions should elicit these chemokine receptors if possible to increase the homing of vaccine-primed cells to sites of infection.

Activation of Effector Memory CD8+ T Cells Following Ligation of BLT1 by Leukotriene B4

2007 ◽  
Vol 119 (1) ◽  
pp. S287-S288
Author(s):  
H. Ohnishi ◽  
N. Miyahara ◽  
C.H. Swasey ◽  
K. Takeda ◽  
A. Dakhama ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Leukotriene B4 ◽  
Effector Memory ◽  
Memory Cd8 T Cells

CD8+ T Cells Are the Effectors of the Contact Dermatitis Induced by Urushiol in Mice and Are Regulated by CD4+ T Cells

1998 ◽  
Vol 117 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Carolina B. López ◽  
Alexis M. Kalergis ◽  
María Inés Becker ◽  
Juan A. Garbarino ◽  
Alfredo E. De Ioannes
Keyword(s):  
T Cells ◽  
Contact Dermatitis ◽  
Cd8 T Cells ◽  
Cd4 T Cells

Characterization of circulating CD8+T cells expressing skin homing and cytotoxic molecules in active non-segmental vitiligo

2013 ◽  
Vol 23 (3) ◽  
pp. 331-338 ◽  
Author(s):  
Bao-Xiang Zhang ◽  
Mao Lin ◽  
Xiao-Yi Qi ◽  
Ron-Xin Zhang ◽  
Zhen-Dong Wei ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Skin Homing ◽  
Cytotoxic Molecules

scholarly journals Leukotriene B4 Receptor-1 Is Essential for Allergen-Mediated Recruitment of CD8+ T Cells and Airway Hyperresponsiveness

2005 ◽  
Vol 174 (8) ◽  
pp. 4979-4984 ◽  
Author(s):  
Nobuaki Miyahara ◽  
Katsuyuki Takeda ◽  
Satoko Miyahara ◽  
Christian Taube ◽  
Anthony Joetham ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Airway Hyperresponsiveness ◽  
Leukotriene B4 ◽  
Leukotriene B4 Receptor
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