Blood Histamine and Basophil Leukocytes in Polycythemia

Background: Blood histamine levels are decreased after severe allergic reactions and in various chronic diseases.Aims: To study blood histamine levels in infants and children with acute infectious and non-infectious, non-allergic, disease.Methods: Blood histamine levels were investigated by a fluorometric method in infants and children admitted to hospital with bronchiolitis, non-wheezing bronchitis, acute infections of the urinary tract, skin and ear-nose-throat, gastroenteritis, or hyperthermia of unknown aetiology. Results of blood histamine levels and white blood cell counts were compared with those obtained for children recovering from benign non-infectious, non-allergic illnesses.Results: As compared with control children, white blood cell numbers were significantly increased in children with acute infections of the urinary tract, skin and ear-nose-throat, and were significantly decreased in children with gastroenteritis. Blood histamine levels were significantly lower in children with gastroenteritis and hyperthermia than in children with other diseases and control children. It was not possible to correlate blood histamine levels and the number of blood basophils.Conclusions: BHL are significantly decreased in infants and children with acute gastroenteritis and hyperthermia of unknown aetiology. The mechanisms responsible for the decrease in blood histamine levels in children with gastroenteritis and hyperthermia are discussed.

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Blood histamine levels in cotton-dust exposed workers in a textile mill of Ahmedabad

American Journal of Industrial Medicine ◽

10.1002/ajim.4700120409 ◽

1987 ◽

Vol 12 (4) ◽

pp. 439-443 ◽

Cited By ~ 1

Author(s):

J. R. Parikh ◽

H. Venkatakrishna-Bhatt ◽

G. M. Panchal

Keyword(s):

Cotton Dust ◽

Textile Mill ◽

Exposed Workers ◽

Blood Histamine

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Effect of low-frequency vibration on blood histamine levels in albino rats

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00792230 ◽

1973 ◽

Vol 76 (3) ◽

pp. 1034-1035

Author(s):

V. Gylybova ◽

M. Zlateva

Keyword(s):

Low Frequency ◽

Albino Rats ◽

Low Frequency Vibration ◽

Blood Histamine

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The sequential estimation of plasma catecholamines and whole blood histamine in myocardial infarction

American Heart Journal ◽

10.1016/0002-8703(71)90262-6 ◽

1971 ◽

Vol 82 (2) ◽

pp. 171-179 ◽

Cited By ~ 48

Author(s):

John Griffiths ◽

Fred Leung

Keyword(s):

Myocardial Infarction ◽

Whole Blood ◽

Plasma Catecholamines ◽

Sequential Estimation ◽

Blood Histamine

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A Study of Histamine in Myeloproliferative Disease

Blood ◽

10.1182/blood.v28.6.795.795 ◽

1966 ◽

Vol 28 (6) ◽

pp. 795-806 ◽

Cited By ~ 74

Author(s):

HARRIET S. GILBERT ◽

RICHARD R. P. WARNER ◽

LOUIS R. WASSERMAN

Keyword(s):

Polycythemia Vera ◽

Clinical Manifestations ◽

White Cell ◽

Histamine Content ◽

Elevated Blood ◽

Myeloproliferative Disease ◽

Myeloid Metaplasia ◽

Objective Evidence ◽

Blood Histamine

Abstract 1. Whole blood histamine content was measured in 80 patients with myeloproliferative disease. Increased levels were found in 60 per cent of patients with uncontrolled polycythemia vera, in 7 per cent of patients with polycythemia vera being controlled by myelosuppressive therapy, and in 71 per cent of a group with "spent" polycythemia, myeloid metaplasia and myelofibrosis. 2. The excretion of histamine in the urine was measured in 60 patients, 30 with elevated blood histamine and 30 with normal blood histamine. The urine findings paralleled the blood findings in 90 per cent of the cases. 3. Measurements of cell-poor and cell-rich fractions of blood showed that the histamine is contained in the white cell fraction. Elevated basophil counts were present in 50 per cent of the patients and occurred with the greatest frequency in the groups with elevated blood and urine histamine. A rough correlation between the basophil count and the histamine content of blood and white cell fractions was observed in normal subjects and most cases with myeloproliferative disease. Data obtained in some cases of myeloproliferative disease suggest that the histamine content of the basophil may be abnormal and that other granulocytes may contribute to the total leukocyte histamine. 4. Myelosuppressive agents produced a reduction in histamine (expressed per 109 myeloid cells) and a decrease in urine histamine as control of the myeloproliferative process was achieved. Treatment with phlebotomy alone produced no change in histamine levels. 5. The incidence of pruritus, upper gastrointestinal distress and urticarial manifestations was increased 7-fold, 4-fold and 12-fold, respectively, in patients with elevated histamine levels as compared with those who had normal histamine levels. 6. Cyproheptadine, a potent antihistaminic, successfully controlled pruritus, relieved pyrosis and suppressed urticarial eruptions in patients with elevated histamine levels. Suppression of the reaction to subcutaneously administered codeine (a histamine-releaser) afforded objective evidence that cyproheptadine blocked the effects of histamine release in vivo. 7. The metabolism of histamine and the role of elevated histamine levels in the clinical manifestations and pathophysiology of myeloproliferative disease are discussed.

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