STUDIES ON SKIN SURFACE BARRIER FUNCTIONS-SKIN SURFACE LIPIDS AND TRANSEPIDERMAL WATER LOSS IN ATOPIC SKIN DURING CHILDHOOD-

1978 ◽  
Vol 5 (5) ◽  
pp. 223-229 ◽  
Author(s):  
Takashi Abe ◽  
Muneo Ohkido ◽  
Kazuya Yamamoto
Keyword(s):  
Water Loss ◽  
Skin Surface ◽  
Transepidermal Water Loss ◽  
Surface Barrier ◽  
Barrier Functions ◽  
Surface Lipids ◽  
Atopic Skin ◽  
Skin Surface Lipids

scholarly journals Lipidomics Profiling of Skin Surface Lipids in Senile Pruritus

2020 ◽  
Author(s):  
xiaolei Ma ◽  
Lulu Lu ◽  
Zheng Zhao ◽  
Mingru Cai ◽  
Na Gao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Surface ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Control Subjects ◽  
Surface Lipids ◽  
Peking University ◽  
Skin Surface Lipids

Abstract Background: Senile pruritus is common, yet its etiology remains unknown. Aging-associated skin barrier defects and skin surface lipids (SSL) alterations have been postulated to play important roles in its occurrence. In the present study, the lipidomic profiles of SSLs in elderly patients were examined to better understand the potential causes of senile pruritus. Methods: Transepidermal water loss (TEWL) was evaluated to assess the skin barrier function. The Ameliorated Kawashima Itch Scale score was used to measure the pruritus severity. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and multivariate data analysis were employed to investigate SSL alterations. Results: The results showed that senile pruritus patients had higher TEWL values than control subjects (13.13±4.28 versus 6.71±2.45, P<0.01). LC-MS/MS revealed significant differences in the lipidomic profiles and identified 81 species of SSLs that differed between the two groups. Compared with control subjects, senile pruritus patients had increased levels of ceramides (Cers), diacylglycerols, fatty acids, phosphatidylcholines, phosphatidylethanolamines, phytosphingosines, sphingosines, diacylceryl-3-O-carboxyhydroxymethylcholine, diacylglyceryl trimethylhomoserine, and unsaturated free fatty acids, but decreased levels of triacylglycerol. Cer-EOS, Cer-NDS, and Cer-NS were positively correlated with TEWL value (P<0.05). Pruritus severity score was positively correlated with sphingomyelin, Cer-NP, Cer-AS, Cer-NDS, and Cer-NS, but negatively correlated with Cer-BS, Cer-EODS, Cer-EOS, and Cer-AP. Conclusions: The present study indicated that patients with senile pruritus have impaired skin barrier function and altered SSL composition. Certain SSL species identified in this study may be potential targets for future studies on the pathogenesis of senile pruritus.Trial registration: Peking University International Hospital (Number: YN2018QN04; date: January 2019).

Analysis of Skin Surface Lipids

1975 ◽  
Vol 37 (6) ◽  
pp. 909-917 ◽  
Author(s):  
Tokuji HIROWATARI
Keyword(s):  
Skin Surface ◽  
Surface Lipids ◽  
Skin Surface Lipids

scholarly journals The Composition of Rat Skin Surface Lipids. Analysis of the Saponifiable and Nonsaponifiable Fractions.

1964 ◽  
Vol 18 ◽  
pp. 671-680 ◽  
Author(s):  
T. Nikkari ◽  
E. Haahti ◽  
Artturi I. Virtanen ◽  
I. Wadsö ◽  
Lennart Nilsson
Keyword(s):  
Skin Surface ◽  
Rat Skin ◽  
Surface Lipids ◽  
Skin Surface Lipids ◽  
Lipids Analysis

Quantitative evaluation of skin surface lipids

1995 ◽  
Vol 13 (4) ◽  
pp. 307-321 ◽  
Author(s):  
Peter Clarys ◽  
Andre Barel
Keyword(s):  
Quantitative Evaluation ◽  
Skin Surface ◽  
Surface Lipids ◽  
Skin Surface Lipids

An untargeted investigation into the skin surface lipidome in the West Highland white terrier dog, with and without atopic dermatitis

2020 ◽  
Author(s):  
Helen Louise Orbell ◽  
Nick J Cave ◽  
Katharina Parry ◽  
Craig E Griffin
Keyword(s):  
Atopic Dermatitis ◽  
Lipid Analysis ◽  
Critical Role ◽  
Skin Barrier ◽  
Disease Status ◽  
Skin Surface ◽  
Surface Lipids ◽  
Skin Surface Lipids ◽  
Secondary Hypothesis ◽  
Unaffected Skin

Abstract Background – The skin barrier is important in the pathogenesis of atopic dermatitis and stratum corneum lipids have a critical role. Skin surface lipids have been largely overlooked but also contribute to barrier function. An untargeted approach was used to compare the skin surface lipids from atopic and non-atopic West Highland White terrier dogs. The primary hypothesis was that a difference in the lipidome of atopic and non-atopic dogs would be found and the secondary hypothesis was that affected and unaffected skin would differ in lipid profile.Results – Thirty-nine dogs were classified into one of four disease status groups based on strict criteria. Samples for lipid analysis were collected from affected and unaffected skin, and liquid chromatography/mass spectrometry found 421 lipid soluble features. Ten lipids were positively identified. Statistical analysis could not distinguish between non-atopic and atopic dogs. Partial least squares-discriminant analysis revealed a difference in the lipid profiles from affected and non-affected skin irrespective of disease status. Conclusions – An untargeted approach found a large array of unidentified lipids from the skin surface. There was a difference in the lipidome between affected and unaffected skin that was not related to disease status. Investigation into the lipidome of the skin surface in health and disease is an emerging area of research which could have clinical and therapeutic applications.

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