A Case of Classic Kaposi's Sarcoma in a Japanese Man: Detection of Human Herpes Virus 8 (HHV-8) Infection by Means of Polymerase Chain Reaction and Immunofluorescence Assay

There is sparse information in humans on graft-versushost (GVH) lymphadenopathy. A 15-month-old male received a liver and small bowel transplant for short bowel after gastroschisis. At 21 days he developed a GVH-like skin rash. Flow cytometry demonstrated 16.1% circulating donor cells. Polymerase chain reaction for Epstein-Barr virus was negative. Two months later, the rash recurred with diffuse lymphadenopathy. Lymph node biopsy showed effaced architecture without visible follicles, large numbers of CD79a+ immunoblasts interspersed with smaller CD3+ and CD8+ cells, and prominent dendritic cell hyperplasia. Human herpes virus 8, cytomegalovirus, and EBER-1 probes were negative, as was polymerase chain reaction for human herpes virus 6. Allograft intestinal biopsies on days 10 and 24 had a similar infiltrate. The features appeared to be those of lymphocytes trafficking between the graft and host with a mixed lymphocyte reaction in situ, a GVH-type reaction without tissue damage. The reaction was self-limiting in the intestinal graft, and the lymphadenopathy resolved with some decrease in immunosupression. Circulating donor cells fell to 2.5% by day 62, and the child has been rejection free on low-dose immunosuppression.

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MOLECULAR DETECTION OF KAPOSI’S SARCOMA ASSOCIATED VIRUS (HUMAN HERPES VIRUS 8) IN SINO-NASAL CARCINOMA TISSUES

10.36295/asro.2020.23434 ◽

2020 ◽

Vol 23 (04) ◽

pp. 286-297

Author(s):

Hind Hamed Shaker ◽

Luma Amer Yasir ◽

Ausama Abed-Alkadum Alajeely ◽

Saad Hasan Mohammed Ali ◽

Shakir H. Mohammed Al-Alwany

Keyword(s):

Kaposi's Sarcoma ◽

Herpes Virus ◽

Molecular Detection ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus ◽

Nasal Carcinoma

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Human herpes virus 8 (Kaposi’s sarcoma herpesvirus)

Oral Oncology ◽

10.1016/s1368-8375(97)00038-9 ◽

1998 ◽

Vol 34 (1) ◽

pp. 5-14 ◽

Cited By ~ 11

Author(s):

S.R Porter ◽

L Di Alberti ◽

N Kumar

Keyword(s):

Kaposi's Sarcoma ◽

Herpes Virus ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus

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Detection of human herpes virus 8 DNA and sequence polymorphism in classical, epidemic, and iatrogenic Kaposi's sarcoma in South Africa

Journal of Medical Virology ◽

10.1002/(sici)1096-9071(199706)52:2<168::aid-jmv9>3.0.co;2-1 ◽

1997 ◽

Vol 52 (2) ◽

pp. 168-172 ◽

Cited By ~ 11

Author(s):

Susan Engelbrecht ◽

Florette K. Treurnicht ◽

Johann W. Schneider ◽

H. Francois Jordaan ◽

Jan G. Steytler ◽

...

Keyword(s):

South Africa ◽

Kaposi's Sarcoma ◽

Herpes Virus ◽

Kaposi’S Sarcoma ◽

Sequence Polymorphism ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus

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Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: lack of association with Bcl-2 and p53 protein expression

Molecular Pathology ◽

10.1136/mp.51.3.155 ◽

1998 ◽

Vol 51 (3) ◽

pp. 155-159 ◽

Cited By ~ 8

Author(s):

M. M. Kennedy ◽

J. J. O'Leary ◽

J. L. Oates ◽

S. B. Lucas ◽

D. D. Howells ◽

...

Keyword(s):

Protein Expression ◽

Kaposi's Sarcoma ◽

Herpes Virus ◽

P53 Protein ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

P53 Protein Expression ◽

Human Herpes Virus ◽

Herpès Virus

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Absence of Kaposi's sarcoma-associated human herpes virus 8 in transplantation-related tumors other than Kaposi's sarcoma

Transplantation Proceedings ◽

10.1016/s0041-1345(96)00155-8 ◽

1997 ◽

Vol 29 (1-2) ◽

pp. 836-837 ◽

Cited By ~ 10

Author(s):

G. Cathomas ◽

M. Tamm ◽

C.E. McGandy ◽

P.H. Itin ◽

F. Gudat ◽

...

Keyword(s):

Kaposi's Sarcoma ◽

Herpes Virus ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus

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Malignancies in HIV

Fundamentals of HIV Medicine 2019 ◽

10.1093/med/9780190942496.003.0034 ◽

2019 ◽

pp. 337-378

Author(s):

Eva Clark ◽

Elizabeth Chiao

Keyword(s):

Antiretroviral Therapy ◽

Hiv Infection ◽

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Human Herpes ◽

Human Herpes Virus 8 ◽

Human Herpes Virus ◽

Herpès Virus ◽

The Impact

• Review the epidemiology and role of antiretroviral therapy (ART) on the impact of AIDS-defining malignancies, which remain common among individuals with HIV. • Discuss the role of human herpes virus-8 (HHV-8) in the development of Kaposi’s sarcoma (KS), which remains the most common tumor associated with HIV infection....

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