Late-onset self-healing reticulohistiocytosis: Pediatric case of Hashimoto?Pritzker type Langerhans cell histiocytosis

Background: An unusual and not yet reported clinical presentation of pure cutaneous Langerhans cell histiocytosis (LCH) that was a diagnostic dilemma. Objective: To bring to light the newer presentation of this disease. Method: The case was managed on clinical grounds initially as cellulitis. However, after the investigations and confirmation of the diagnosis, she was managed symptomatically. Results: Pure cutaneous LCH may manifest in early adulthood with features of cellulitis, erythematous edematous vesicular plaques, and nodules distributed in the flexural acral areas. Conclusion: Pure cutaneous LCH may have an acute late onset with unusual morphology as cellulitis, inverse acral distribution, and self-healing.

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Late-onset self-healing Langerhans cell histiocytosis in a patient with atopic dermatitis

The Journal of Dermatology ◽

10.1111/1346-8138.12488 ◽

2014 ◽

Vol 41 (5) ◽

pp. 450-451 ◽

Cited By ~ 1

Author(s):

Takeshi Nakahara ◽

Makiko Kido-Nakahara ◽

Eriko Itoh ◽

Masutaka Furue

Keyword(s):

Atopic Dermatitis ◽

Langerhans Cell Histiocytosis ◽

Late Onset ◽

Langerhans Cell ◽

Self Healing

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Solitary, Late-onset, Self-healing Langerhans Cell Histiocytosis

Acta Dermato Venereologica ◽

10.2340/00015555-0990 ◽

2011 ◽

Vol 91 (1) ◽

pp. 103-104 ◽

Cited By ~ 7

Author(s):

S Murata ◽

Y Yoshida ◽

K Adachi ◽

E Morita ◽

O Yamamoto

Keyword(s):

Langerhans Cell Histiocytosis ◽

Late Onset ◽

Langerhans Cell ◽

Self Healing

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Self-Healing Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption

Journal of Cutaneous Medicine and Surgery ◽

10.1007/s10227-001-0014-0 ◽

2001 ◽

Vol 5 (6) ◽

pp. 486-489 ◽

Cited By ~ 7

Author(s):

Kelli W. Morgan ◽

Jeffrey P. Callen

Keyword(s):

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Self Healing

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92. Vulvar and Oral Langerhans Cell Histiocytosis: A Pediatric Case Report

Journal of Pediatric and Adolescent Gynecology ◽

10.1016/j.jpag.2020.01.024 ◽

2020 ◽

Vol 33 (2) ◽

pp. 219

Author(s):

Jennifer Nestor ◽

Donna Perruzza ◽

Rafat Ahmed ◽

Saifuddin Mama

Keyword(s):

Case Report ◽

Langerhans Cell Histiocytosis ◽

Langerhans Cell ◽

Pediatric Case

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Self-Healing Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347540100500605 ◽

2001 ◽

Vol 5 (6) ◽

pp. 486-489 ◽

Cited By ~ 5

Author(s):

Kelli W. Morgan ◽

Jeffrey P. Callen

Keyword(s):

Langerhans Cell Histiocytosis ◽

Rare Condition ◽

Signs And Symptoms ◽

Male Infant ◽

Skin Lesions ◽

Langerhans Cell ◽

Self Healing ◽

Systemic Involvement ◽

S 100 ◽

Simplex Virus

Background: Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare condition which may present at birth or during the neonatal period. It is usually characterized by the eruption of multiple, disseminated, red-brown papules and nodules which may increase in size and number during the first few weeks of life. Systemic signs are usually absent except for occasional mild hepatomegaly. Objective: We present a 3.5-kg male infant who presented at birth with numerous diffuse, erythematous, crusted erosions. He was presumed to have congenital herpes simplex virus (HSV) and was started on IV acyclovir. Histopathologic examination revealed a mixed inflammatory infiltrate with numerous histiocytes which were S-100 and peanut agglutin positive consistent with CSHLCH. Further workup did not reveal any signs of systemic involvement. Conclusion: CSHLCH has rarely been reported to present as a papulovesicular eruption at birth. In these cases, a viral etiology is commonly entertained in the differential diagnosis. Despite the spontaneous regression of skin lesions in CSHLCH, close followup is required to evaluate for systemic signs and symptoms associated with latent Letterer–Siwe disease.

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