Inhibitory effect of coenzyme Q1 on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line

2006 ◽  
Vol 97 (8) ◽  
pp. 716-723 ◽  
Author(s):  
Yuko Yonezawa ◽  
Isoko Kuriyama ◽  
Atsushi Fukuoh ◽  
Tsuyoshi Muta ◽  
Dongchon Kang ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Topoisomerase Ii ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Inhibitory Effect ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Eukaryotic Dna

scholarly journals ATPase Domain of Eukaryotic DNA Topoisomerase II

2001 ◽  
Vol 277 (8) ◽  
pp. 5944-5951 ◽  
Author(s):  
Tao Hu ◽  
Harvey Sage ◽  
Tao-shih Hsieh
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Atpase Domain ◽  
Dna Topoisomerase ◽  
Eukaryotic Dna

scholarly journals The Synthesis and Antitumor Activity of the Sodium Salt and Copper (II) Complex of N-[(Trimethylamineboryl)-Carbonyl]-L-Phenylalanine Methyl Ester

1998 ◽  
Vol 5 (1) ◽  
pp. 1-9 ◽  
Author(s):  
M. C. Miller ◽  
A. Sood ◽  
B. F. Spielvogel ◽  
I. H. Hall
Keyword(s):  
Dna Polymerase ◽  
Sodium Salt ◽  
Topoisomerase Ii ◽  
Parent Compound ◽  
Leukemic Cell ◽  
Acid Synthesis ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Dna And Rna ◽  
Phenylalanine Methyl Ester

Sodium N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine 2 and {N-[(trimethylamineboryl)-carbonyl]-L-phenylalanyl- carbxylato}-bis-{N-[(trimethylaminebryl)-carbonyl]-L-phenylalanine} dicopper (II) 3 were successfully synthesized. The agents blocked L1210 leukemic cell DNA and RNA syntheses by inhibiting multiple enzyme activities for nucleic acid synthesis, e.g. PRPP amido transferase, IMP dehydrogenase, DNA polymerase α, thymidine kinase, and TMP kinase. The copper (II) complex 3 demonstrated improved ability to inhibit L1210 partially purified DNA topoisomerase II compared to the parent compound while the sodium salt was inactive at 100 μM.

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