Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin

2006 ◽  
Vol 155 (1) ◽  
pp. 119-128 ◽  
Author(s):  
N. Ünver ◽  
P. Freyschmidt-Paul ◽  
S. Hörster ◽  
H. Wenck ◽  
F. Stäb ◽  
...  
Keyword(s):  
Factor Xiiia ◽  
Ageing Skin ◽  
Dermal Melanin

Molecular Analysis in Factor XIIIA Deficiency

1995 ◽  
Vol 73 (05) ◽  
pp. 895-895 ◽  
Author(s):  
S Aslam ◽  
G R Standen
Keyword(s):  
Molecular Analysis ◽  
Factor Xiiia

Tridegin, a Novel Peptidic Inhibitor of Factor XIIIa from the Leech, Haementeria ghilianii, Enhances Fibrinolysis In Vitro

1997 ◽  
Vol 77 (05) ◽  
pp. 0959-0963 ◽  
Author(s):  
Lisa Seale ◽  
Sarah Finney ◽  
Roy T Sawyer ◽  
Robert B Wallis
Keyword(s):  
Potent Inhibitor ◽  
Platelet Rich Plasma ◽  
Factor Xiiia ◽  
Cross Linking ◽  
Fibrinolytic Enzymes ◽  
Small Polypeptide ◽  
Tissue Plasminogen ◽  
Protein Cross Linking

SummaryTridegin is a potent inhibitor of factor Xllla from the leech, Haementeria ghilianii, which inhibits protein cross-linking. It modifies plasmin-mediated fibrin degradation as shown by the absence of D-dimer and approximately halves the time for fibrinolysis. Plasma clots formed in the presence of Tridegin lyse more rapidly when either streptokinase, tissue plasminogen activator or hementin is added 2 h after clot formation. The effect of Tridegin is markedly increased if clots are formed from platelet-rich plasma. Platelet-rich plasma clots are lysed much more slowly by the fibrinolytic enzymes used and if Tridegin is present, the rate of lysis returns almost to that of platelet- free clots. These studies indicate the important role of platelets in conferring resistance to commonly used fibrinolytic enzymes and suggest that protein cross-linking is an important step in this effect. Moreover they indicate that Tridegin, a small polypeptide, may have potential as an adjunct to thrombolytic therapy.

Delayed intermolecular ??-chain cross-linking by factor XIIIa in fibrinogen Asahi characterized by a ??-Met-310 to Thr substitution with an N-glycosylated ??-Asn-308

1990 ◽  
Vol 1 (5) ◽  
pp. 557-560 ◽  
Author(s):  
K. Yamazumi ◽  
K. Shimura ◽  
H. Maekawa ◽  
S. Muramatsu ◽  
S. Terukina ◽  
...  
Keyword(s):  
Factor Xiiia ◽  
Cross Linking

Hemostatic Parameters and Platelet Activation Marker Expression in Cyanotic and Acyanotic Pediatric Patients Undergoing Cardiac Surgery in the Presence of Tranexamic Acid

2000 ◽  
Vol 83 (01) ◽  
pp. 54-59 ◽  
Author(s):  
Elena Levin ◽  
John Wu ◽  
John Alexander ◽  
Clayton Reichart ◽  
Suvro Sett ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Platelet Activation ◽  
Pediatric Patients ◽  
Factor Xiiia ◽  
Congenital Defects ◽  
Plasma Factor ◽  
Pai 1 ◽  
D Dimer

SummaryWe have investigated hemostatic parameters including platelet activation in 56 pediatric patients with or without cyanosis undergoing cardiopulmonary bypass (CPB) and cardiac surgery to repair congenital defects. Patients were participants in a study assessing the effects of tranexamic acid on surgery-related blood loss. Parameters monitored included blood loss, prothrombin F1.2, thrombin-antithrombin complexes, t-PA, PAI-1, plasminogen, fibrin D-dimer, and plasma factor XIII. Additionally, flow cytometry monitored platelet degranulation (P-selectin or CD63), as well as surface-bound fibrinogen, von Willebrand factor and factor XIIIa. Cyanotic patients had evidence of supranormal coagulation activation as both fibrin D-dimer and PAI-1 levels were elevated prior to surgery. While the extent of expression of Pselectin or CD63 was not informative, platelet-associated factor XIIIa was elevated in cyanotic patients at baseline. In both patient groups, CPB altered platelet activation state and coagulation status irrespective of the use of tranexamic acid.

scholarly journals Factor XIIIA Transglutaminase Crosslinks AT1 Receptor Dimers of Monocytes at the Onset of Atherosclerosis

Cell ◽  
2004 ◽  
Vol 119 (3) ◽  
pp. 343-354 ◽  
Author(s):  
Said AbdAlla ◽  
Heinz Lother ◽  
Andreas Langer ◽  
Yasser el Faramawy ◽  
Ursula Quitterer
Keyword(s):  
At1 Receptor ◽  
Factor Xiiia ◽  
Receptor Dimers
Sign in / Sign up

Export Citation Format

Share Document