Acute lymphoblastic transformation of essential thrombocythaemia

2008 ◽  
Vol 89 (4) ◽  
pp. 921-922 ◽  
Author(s):  
P. T. Murphy ◽  
M. Sivakumaran ◽  
F. van Rhee ◽  
A. E. WATMORE ◽  
V. E. Mitchell
Author(s):  
T. Mullin ◽  
G. Yee ◽  
M. Aheam ◽  
J. Trujillo

There have been numerous reports in the current literature suggesting that hematopoietic precursor cells in some human chronic myelocytic leukemias (CML) undergo lymphoblastic transformation at the time of the acute blast crisis (BC) stage. The primary evidence offered in support of this transformation theory--lymphoblastic appearing morphology, increased terminal deoxynucleotidyl transferase (TdT) activity, and chemotherapeutic sensitivity to vincristine and prednisone--has been indirect, however, since these features may occur in nonlymphoid cells. More direct support for the Pre-B lineage of these cells has recently been provided by immunofluorescent light microscopic studies demonstrating the presence of intracytoplasmic immunoglobulin M (IgM) in these CML-BC cells.


2006 ◽  
Vol 30 ◽  
pp. S1 ◽  
Author(s):  
D. Pospisilova ◽  
V. Mihal ◽  
T. Votava ◽  
J. Hak ◽  
H. Ptoszkova ◽  
...  

2005 ◽  
Vol 128 (3) ◽  
pp. 273-273
Author(s):  
Fabio Silvio Taccone ◽  
Walter Feremans

2011 ◽  
Vol 156 (2) ◽  
pp. 281-284 ◽  
Author(s):  
Francesca Palandri ◽  
Nicola Polverelli ◽  
Lucia Catani ◽  
Daria Sollazzo ◽  
Emanuela Ottaviani ◽  
...  

2012 ◽  
Vol 66 (10) ◽  
pp. 976-983 ◽  
Author(s):  
R. Frewin ◽  
A. Dowson

2011 ◽  
Vol 41 (2) ◽  
pp. 191-196 ◽  
Author(s):  
G-C. Wong ◽  
G. L. S. Kam ◽  
E. S. C. Koay

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