scholarly journals Decreased half-life time of plasma von Willebrand factor collagen binding activity in essential thrombocythaemia: normalization after cytoreduction of the increased platelet count

1997 ◽  
Vol 99 (4) ◽  
pp. 832-836 ◽  
Author(s):  
Perry J. J Van Genderen ◽  
Fransisco J Prins ◽  
Irene S. Lucas ◽  
Desiree Van De Moesdijk ◽  
Huub H. D. M. Van Vliet ◽  
...  
Keyword(s):  
Platelet Count ◽  
Von Willebrand Factor ◽  
Half Life ◽  
Life Time ◽  
Binding Activity ◽  
Essential Thrombocythaemia ◽  
Collagen Binding ◽  
Von Willebrand ◽  
Willebrand Factor

Plasma Derived von Willebrand Factor Preparations: Collagen Binding and Ristocetin Cofactor Activities

1997 ◽  
Vol 78 (02) ◽  
pp. 930-933 ◽  
Author(s):  
Ping Chang ◽  
D L Aronson
Keyword(s):  
Von Willebrand Factor ◽  
Functional Activity ◽  
Binding Activity ◽  
Collagen Binding ◽  
Binding Function ◽  
Cofactor Activity ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Ristocetin Cofactor ◽  
Ristocetin Cofactor Activity

SummaryFive plasma preparations (11 lots) used in the treatment of von Willebrand’s disease (vWD) were evaluated. The collagen binding function of von Willebrand factor (vWF) containing preparations was compared with the ristocetin cofactor activity and the vWF antigen. Some preparations have higher ratio of functional activity (ristocetin cofactor and collagen binding) relative to the antigen than is found in normal plasma. The ristocetin cofactor activity and the collagen binding activity are tightly correlated (r = .95). Ultracentrifugal (UCF) analysis was used to compare the size distribution of vWf antigen, ristocetin cofactor and collagen binding activity. The sedimentation of all of the vWF parameters in the plasma products was slower than in plasma. In plasma products the ristocetin cofactor activity sediments the most rapidly, the collagen binding activity is slower and the antigen the slowest. The collagen/antigen ratio decreases with decreasing vWF size. Assignment of potency to vWF containing preparations utilizing the collagen binding activity may be more precise and as accurate as with the traditional ristocetin cofactor assay.

Standardization and comparison of nonautomated assays to measure the collagen binding activity of von Willebrand factor

2018 ◽  
Vol 40 (5) ◽  
pp. 597-603 ◽  
Author(s):  
L. M. M. Oliveira ◽  
M. V. A. Amorim ◽  
C. A. Corsini ◽  
C. C. A. Neto ◽  
D. G. Chaves
Keyword(s):  
Von Willebrand Factor ◽  
Binding Activity ◽  
Collagen Binding ◽  
Von Willebrand ◽  
Willebrand Factor

A comparative evaluation of a new fully automated assay for von Willebrand factor collagen binding activity to an established method

Haemophilia ◽  
2017 ◽  
Vol 24 (1) ◽  
pp. 156-161 ◽  
Author(s):  
F. Stufano ◽  
L. Baronciani ◽  
D. Mane-Padros ◽  
G. Cozzi ◽  
S. Faraudo ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Comparative Evaluation ◽  
Binding Activity ◽  
Established Method ◽  
Collagen Binding ◽  
Automated Assay ◽  
Von Willebrand ◽  
Willebrand Factor

A shorter von Willebrand factor survival in O blood group subjects explains how ABO determinants influence plasma von Willebrand factor

Blood ◽  
2008 ◽  
Vol 111 (7) ◽  
pp. 3540-3545 ◽  
Author(s):  
Lisa Gallinaro ◽  
Maria Grazia Cattini ◽  
Maryta Sztukowska ◽  
Roberto Padrini ◽  
Francesca Sartorello ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Half Life ◽  
Healthy Subjects ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Collagen Binding ◽  
Elimination Half ◽  
Time Courses ◽  
Von Willebrand ◽  
Willebrand Factor

AbstractABO blood groups greatly influence circulating von Willebrand factor (VWF) levels, and O group subjects have lower VWF values. In this study, we investigated whether ABO groups affect VWF survival by monitoring the post-DDAVP (1-desamino-8-d arginine vasopressin) time courses of VWF antigen (VWF:Ag), VWF collagen binding (VWF:CB), and factor VIII (FVIII) in 47 healthy subjects (28 O and 19 non-O blood groups). The elimination half-life (T1/2el) of VWF was found significantly shorter in O than in non-O subjects (10.0 ± 0.8 hours vs 25.5 ± 5.3 hours, respectively; P < .01), as was the T1/2el of VWF:CB (7.9 ± 0.5 hours vs 20.9 ± 4.5 hours; P < .01). A direct linear correlation was found between basal VWF:Ag and T1/2el, subjects with higher VWF levels having longer-surviving VWF. ABO blood groups appeared to strongly influence VWF clearance, but not its synthesis or release from endothelial cells. The VWF propeptide to VWF:Ag ratio, useful for predicting an increased VWF clearance, was found significantly higher in O than in non-O individuals (1.6 ± 0.1 vs 1.2 ± 0.5, P < .001), with values that correlated inversely with T1/2el (P < .001). Based on these findings, we conclude that the lower VWF values in O group individuals is attributable to a shorter VWF survival and circulating VWF values are strongly influenced by its half-life.

von Willebrand factor-collagen binding activity is increased in newborns and infants

1995 ◽  
Vol 84 (6) ◽  
pp. 697-700 ◽  
Author(s):  
KB Thomas ◽  
AH Sutor ◽  
N Altinkaya ◽  
A Grohmann ◽  
A Zehenter ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Binding Activity ◽  
Collagen Binding ◽  
Von Willebrand ◽  
Willebrand Factor
Sign in / Sign up

Export Citation Format

Share Document