THE RATIO OF THYROXINE TO THYROXINE-BINDING GLOBULIN IN THE ASSESSMENT OF THYROID FUNCTION

1979 ◽  
Vol 11 (3) ◽  
pp. 333-342 ◽  
Author(s):  
W. A. BURR ◽  
S. E. EVANS ◽  
J. LEE ◽  
H. P. PRINCÉ ◽  
D. B. RAMSDEN
Keyword(s):  
Thyroid Function ◽  
Thyroxine Binding Globulin

scholarly journals The T4:TBG Ratio: A Re-Evaluation with Particular Reference to Low and High Serum TBG Levels

1982 ◽  
Vol 19 (2) ◽  
pp. 101-103 ◽  
Author(s):  
E C Attwood ◽  
G E Atkin
Keyword(s):  
Retrospective Study ◽  
Thyroid Function ◽  
Reference Range ◽  
High Serum ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Thyroxine Binding Globulin ◽  
Biochemical Investigation ◽  
Small Increments ◽  
Routine Assay

The thyroxine: thyroxine-binding globulin (T4: TBG) ratio is now an established part of the biochemical investigation of thyroid function. Reference ranges have been reported for euthyroid subjects with TBG levels within the range 6–16 mg/l. Routine assay of TBG on all thyroid function tests in this laboratory has suggested that, in patients with low or high TBG levels, the established reference ranges for T4:TBG may not be strictly applicable. A retrospective study has been made of a large number of thyroid function requests, including serum total T4, free T4, TBG, and TSH assays. Evidence is presented to show that in subjects with a TBG level of less than 8 mg/l the reference range for T4: TBG is elevated. Similarly, in subjects with a TBG greater than 16 mg/l, the reference range for T4: TBG is lowered. The data suggest that it is necessary to quote a T4: TBG reference range based on small increments of TBG levels or to relate total T4 reference ranges to those increments.

scholarly journals Effect of passive smoking on thyroid function in infants

1998 ◽  
pp. 379-382 ◽  
Author(s):  
A Gasparoni ◽  
M Autelli ◽  
MF Ravagni-Probizer ◽  
A Bartoli ◽  
M Regazzi-Bonora ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Passive Smoking ◽  
Serum Concentrations ◽  
Free T4 ◽  
Thyroxine Binding Globulin ◽  
Cord Serum ◽  
Group A ◽  
Group B ◽  
Design And Methods

OBJECTIVE: To evaluate the effect of passive smoking on thyroid function in infants. DESIGN AND METHODS: Cord serum tri-iodiothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), TSH, thyroxine binding globulin (TBG), thyroglobulin (TG) and cord plasma thiocyanate were measured at birth, and serum TG and thiocyanate after 1 year of life, in 18 infants born from parents who did not smoke (group A), in 18 infants with a father who smoked (group B) and in 18 infants with parents both being smokers (group C). RESULTS: No significant differences were observed in cord serum concentrations of T3, fT3, T4, fT4, TSH and TBG among the three groups. Median (range) TG concentrations (ng/ml) were 30.2 (5.0-102.0), 56.3 (20.5-208.0) and 76.0 (26.0-199.0) at birth (P=0.009 for groups A and B compared; P=0.0002 for groups A and C compared), and 14.9 (5.4-32.0), 19.5 (10.0-57.5) and 20.0 (14.0-40.7) at 1 year (P=0.017 for groups A and C compared), in the three groups respectively, and thiocyanate concentrations (mmol/l) were 3.3 (0.0-51.4), 12.9 (0.0-122.2) and 27.8 (3.3-184.5) at birth (P=0.015 for groups A and C compared), and 3.1 (0.0-32.7), 6.0 (0.0-47.3) and 20.3 (0.0-230.8) at 1 year (P=0.01 for groups A and C compared) in the three groups respectively. CONCLUSIONS: TG and thiocyanate concentrations at birth and at 1 year of age in infants of smoking parents are greater than in infants with non-smoking parents. These results indicate that the change in thyroid function as evaluated by serum TG concentrations observed at birth can persist at least for 1 year if the exposure to passive smoking from both parents is continued. Increased TG concentrations may be due to a direct effect of thiocyanate on the thyroid gland.

scholarly journals Total over Free Thyroxine Ratio: Prediction of Thyroxine Binding Globulin

1982 ◽  
Vol 19 (2) ◽  
pp. 94-100
Author(s):  
Andries J Bakker ◽  
Ina Terpstra
Keyword(s):  
Thyroid Function ◽  
Binding Proteins ◽  
Free Thyroxine ◽  
The Other ◽  
Calculated Concentration ◽  
Thyroxine Binding Globulin ◽  
Total Thyroxine ◽  
Better Than

Both total thyroxine and free thyroxine concentrations are measured in the Immophase free thyroxine assay. These total and free thyroxine results allow a prediction of the accessory concentrations of thyroxine-binding globulin (TBG). Since abnormal concentrations of TBG often cause problems in the evaluation of thyroid function, we evaluated the possibility of predicting these abnormal values from total and free thyroxine results. Two ways of predicting abnormal concentrations of TBG were evaluated on statistical grounds. The first method, a simple total thyroxine/free thyroxine ratio, proved to be better than the second method, which corrected for the influence of the other thyroxine binding proteins (result: a calculated concentration of TBG). The total thyroxine/free thyroxine ratio predicts abnormally low TBG values, below a ratio of 4000 (certainty 45%) and abnormally high TBG values, above a ratio of 6400 (certainty 89%).

scholarly journals A Study of Thyroid Function in Partial Thyroxine-Binding Globulin Deficiency

2015 ◽  
Vol 21 (2) ◽  
pp. 65-69 ◽  
Author(s):  
Jae Won Lee ◽  
Jang Yong Jin ◽  
Jungho Lee ◽  
Dong Hwan Lee ◽  
Yong Hee Hong
Keyword(s):  
Thyroid Function ◽  
Thyroxine Binding Globulin

Thyroxine Binding Globulin and Thyroid Function Tests in Patients with Hepatocellular Carcinoma

Hepatology ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 72S-76S ◽  
Author(s):  
W. John Kalk ◽  
Michael C. Kew ◽  
Mervyn D. Danilewitz ◽  
Frederick Jacks ◽  
L. Andre Van Der Walt ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thyroid Function ◽  
Thyroid Function Tests ◽  
Thyroxine Binding Globulin ◽  
Function Tests

THYROID FUNCTION IN THE PREMATURE AND THE FULL TERM NEWBORN

1972 ◽  
Vol 70 (3) ◽  
pp. 445-453 ◽  
Author(s):  
Th. Lemarchand-Béraud ◽  
A. R. Genazzani ◽  
F. Bagnoli ◽  
M. Casoli
Keyword(s):  
Thyroid Function ◽  
Binding Capacity ◽  
Perinatal Period ◽  
Thyroxine Binding Globulin ◽  
Serum Thyroxine ◽  
Premature Newborns ◽  
Important Reserve ◽  
Term Newborn ◽  
Free Serum ◽  
Tsh Levels

ABSTRACT Total and free serum thyroxine, plasma thyrotrophin (TSH) levels and, in some cases, the binding capacity of thyroxine-binding globulin (TBG) were measured in normal and premature newborns. In both groups, an acute release of TSH was observed in the first few hours of life, but this was prolonged over a period of 10 days in the premature newborns. The release of TSH induced, in both groups, an increase of total and free serum thyroxine (T4), reaching thyrotoxic levels. The TBG binding capacity, however, remains normal. This thyroid hyperactivity at birth reveals an important reserve of TSH in the perinatal period and the great metabolic needs of the foetus on the first day of life.

Sign in / Sign up

Export Citation Format

Share Document