Chemiluminescence immunoassays for thyroid-function parameters the determination of thyrotropin (TSH), thyroglobulin (Tg), anti-thyroglobulin (anti-Tg), thyroxine binding globulin (TBG), thyroxine (T4) and tri-iodothyronine (T3) in serum

1984 ◽  
Vol 317 (6) ◽  
pp. 722-723
Author(s):  
A. Gadow ◽  
W. G. Wood
Keyword(s):  
Thyroid Function ◽  
Thyroxine Binding Globulin

scholarly journals The T4:TBG Ratio: A Re-Evaluation with Particular Reference to Low and High Serum TBG Levels

1982 ◽  
Vol 19 (2) ◽  
pp. 101-103 ◽  
Author(s):  
E C Attwood ◽  
G E Atkin
Keyword(s):  
Retrospective Study ◽  
Thyroid Function ◽  
Reference Range ◽  
High Serum ◽  
Reference Ranges ◽  
Thyroid Function Tests ◽  
Thyroxine Binding Globulin ◽  
Biochemical Investigation ◽  
Small Increments ◽  
Routine Assay

The thyroxine: thyroxine-binding globulin (T4: TBG) ratio is now an established part of the biochemical investigation of thyroid function. Reference ranges have been reported for euthyroid subjects with TBG levels within the range 6–16 mg/l. Routine assay of TBG on all thyroid function tests in this laboratory has suggested that, in patients with low or high TBG levels, the established reference ranges for T4:TBG may not be strictly applicable. A retrospective study has been made of a large number of thyroid function requests, including serum total T4, free T4, TBG, and TSH assays. Evidence is presented to show that in subjects with a TBG level of less than 8 mg/l the reference range for T4: TBG is elevated. Similarly, in subjects with a TBG greater than 16 mg/l, the reference range for T4: TBG is lowered. The data suggest that it is necessary to quote a T4: TBG reference range based on small increments of TBG levels or to relate total T4 reference ranges to those increments.

Assessment of the value of quantitative thyroid scintigraphy for determination of thyroid function in dogs

2012 ◽  
Vol 53 (5) ◽  
pp. 278-285 ◽  
Author(s):  
R. E. Shiel ◽  
M. Pinilla ◽  
H. McAllister ◽  
C. T. Mooney
Keyword(s):  
Thyroid Function ◽  
Thyroid Scintigraphy

scholarly journals Thyroid function in abnormal uterine bleeding

2019 ◽  
Vol 8 (6) ◽  
pp. 2270
Author(s):  
Ruthvika Kundoor ◽  
Burri Sandhya Rani
Keyword(s):  
Thyroid Function ◽  
Abnormal Uterine Bleeding ◽  
Thyroid Function Test ◽  
Uterine Bleeding ◽  
Reproductive Age ◽  
Age Group ◽  
Clinically Normal ◽  
Biochemical Evaluation ◽  
Menstrual Pattern

Background: AUB is any abnormal uterine bleeding in the absence of any palpable pelvic pathology and demonstrable extra genital causes. AUB is responsible for 10% of gynaecological complaints. Thyroid hormone is very important to affect the menstrual pattern. The objective of this study was to evaluate thyroid function test in women with AUB and to assess the menstrual pattern in women with thyroid dysfunction.Methods: The present study was conducted in the Department of Obstetrics and Gynecology, Laxmi Narasimha Hospital, Hanamkonda, Hyderabad, Telangana, India 80 women of reproductive age group between 15-45 years women with menstrual disorders like menorrhagia, oligomenorrhea, hypomenorrhea, polymenorrhea, metrorrhagia, and amenorrhea. Quantitative determination of T3, T4, and TSH by CLIA estimated in autoanlyser.Results: About 80 women participated in the study in which Most of the subjects belong to 26-30 years of age group. Maximum patients i.e. 41 (51.2%) patients were para one to 2. Commonest cause bleeding pattern was menorrhagia 41.25%. 15 apparently normal patients with AUB belonged to the category of subclinical hypothyroidism (15%). Hormonal levels revealing profound hypothyroidism in patients without any symptoms was present in only 10% of cases. 2.5% of cases had hyperthyroidism though they were clinically normal. Patients who were sub-clinically hypothyroid were maximally presenting as polymenorrhoea (50%) and menorrhagia (12.1%) and only 6.27% of patients had oligomenorrhoea. Patients who were profound hypothyroid were predominantly having polymenorrhagia (83.3%) and (62.5%) of patients had oligomenorrhoea.Conclusions: So, biochemical evaluation of thyroid functioning should be made mandatory in all provisionally diagnosed cases of AUB to detect thyroid dysfunction.

scholarly journals Effect of passive smoking on thyroid function in infants

1998 ◽  
pp. 379-382 ◽  
Author(s):  
A Gasparoni ◽  
M Autelli ◽  
MF Ravagni-Probizer ◽  
A Bartoli ◽  
M Regazzi-Bonora ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Thyroid Function ◽  
Passive Smoking ◽  
Serum Concentrations ◽  
Free T4 ◽  
Thyroxine Binding Globulin ◽  
Cord Serum ◽  
Group A ◽  
Group B ◽  
Design And Methods

OBJECTIVE: To evaluate the effect of passive smoking on thyroid function in infants. DESIGN AND METHODS: Cord serum tri-iodiothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), TSH, thyroxine binding globulin (TBG), thyroglobulin (TG) and cord plasma thiocyanate were measured at birth, and serum TG and thiocyanate after 1 year of life, in 18 infants born from parents who did not smoke (group A), in 18 infants with a father who smoked (group B) and in 18 infants with parents both being smokers (group C). RESULTS: No significant differences were observed in cord serum concentrations of T3, fT3, T4, fT4, TSH and TBG among the three groups. Median (range) TG concentrations (ng/ml) were 30.2 (5.0-102.0), 56.3 (20.5-208.0) and 76.0 (26.0-199.0) at birth (P=0.009 for groups A and B compared; P=0.0002 for groups A and C compared), and 14.9 (5.4-32.0), 19.5 (10.0-57.5) and 20.0 (14.0-40.7) at 1 year (P=0.017 for groups A and C compared), in the three groups respectively, and thiocyanate concentrations (mmol/l) were 3.3 (0.0-51.4), 12.9 (0.0-122.2) and 27.8 (3.3-184.5) at birth (P=0.015 for groups A and C compared), and 3.1 (0.0-32.7), 6.0 (0.0-47.3) and 20.3 (0.0-230.8) at 1 year (P=0.01 for groups A and C compared) in the three groups respectively. CONCLUSIONS: TG and thiocyanate concentrations at birth and at 1 year of age in infants of smoking parents are greater than in infants with non-smoking parents. These results indicate that the change in thyroid function as evaluated by serum TG concentrations observed at birth can persist at least for 1 year if the exposure to passive smoking from both parents is continued. Increased TG concentrations may be due to a direct effect of thiocyanate on the thyroid gland.

THE RATIO OF THYROXINE TO THYROXINE-BINDING GLOBULIN IN THE ASSESSMENT OF THYROID FUNCTION

1979 ◽  
Vol 11 (3) ◽  
pp. 333-342 ◽  
Author(s):  
W. A. BURR ◽  
S. E. EVANS ◽  
J. LEE ◽  
H. P. PRINCÉ ◽  
D. B. RAMSDEN
Keyword(s):  
Thyroid Function ◽  
Thyroxine Binding Globulin

Immunological and clinical characterization of patients with untreated euthyroid and hypothyroid autoimmune thyroiditis. Antibody spectrum, response to TRH and clinical study

1982 ◽  
Vol 100 (3) ◽  
pp. 373-381 ◽  
Author(s):  
W. A. Scherbaum ◽  
G. Stöckle ◽  
J. Wichmann ◽  
P. A. Berg
Keyword(s):  
Thyroid Function ◽  
Striated Muscle ◽  
Islet Cells ◽  
Adrenocortical Function ◽  
Normal Thyroid Function ◽  
High Incidence ◽  
Organ Specific ◽  
Hypothyroid Patients

Abstract. In a region of endemic goitres, 200 untreated patients in whom thyroid microsomal (MCHA) and/or thyroglobulin (TGHA) antibodies have been detected were analyzed and other organ specific autoantibodies were tested. Thyroid function was assessed by a TRH test in all of them. Patients with previous thyroid disease and patients with clinical or biochemical signs of thyrotoxicosis were excluded. In 58 (29%) of the patients diseases coexisted in which a high incidence of autoimmune reactions has been recognized. In the absence of the corresponding clinical disease, 13.7% of the patients had antibodies to parietal cells of the stomach, 3.1% had antibodies to adrenal cortex, 1% to steroid producing gonadal cells, 1% to pancreatic islet cells, and 0.5% of the patients had antibodies to striated muscle fibrils. The incidence of associated organ-specific autoantibodies was no higher in patients with hypothyroidism (36.4%) compared with patients who had a normal thyroid function (27.9%). The determination of a 'significant' thyroid antibody titre is discussed. In 24.5% of the 200 patients a form of hypothyroidism was recognized. Fifty of the patients with TGHA titres ≥ 6400, and 56.2% of those with MCHA ≥ 102400 were hypothyroid. Patients with such titres of thyroid antibodies should be examined and followed up. Patients with associated islet cell or adrenal antibodies should be reinvestigated and followed up observing their glucose tolerance and adrenocortical function, respectively.

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