Homocysteine, traditional risk factors and impaired renal function in coronary artery disease

AbstractBackground: Accelerated coronary atherosclerosis in patients with Kawasaki disease, in conjunction with coronary artery aneurysm and stenosis that characterise this disease, are potential risk factors for developing coronary artery disease in young adults. We aimed to determine the prevalence and predictors of coronary artery disease in adult patients with Kawasaki disease. Methods: All patients aged 18−55 years of age diagnosed with Kawasaki disease were sampled from Nationwide Inpatient Sample database using International Classification of Diseases 9th revision (ICD 9 code 446.1) from 2009 to 2010. Demographics, prevalence of coronary artery disease, and other traditional risk factors in adult patients with Kawasaki disease were analysed using ICD 9 codes. Results: The prevalence of Kawasaki disease among adults was 0.0005% (n=215) of all in-hospital admissions in United States. The mean age was 27.3 years with women (27.6 years) older than men (27.1 years). Traditional risk factors were hypertension (21%), hyperlipidaemia (15.6%), diabetes (11.5%), tobacco use (8.8%), and obesity (8.8%), with no significant difference between men and women. Coronary artery disease (32.4%), however, was more prevalent in men (44.7%) than in women (12.1%; p=0.03). In multivariate regression analysis, after adjusting for demographics and traditional risk factors, hypertension (OR=13.2, p=0.03) was an independent risk factor of coronary artery disease. Conclusion: There was increased preponderance of coronary artery disease in men with Kawasaki disease. On multivariate analysis, hypertension was found to be the only independent predictor of coronary artery disease in this population after adjusting for other risk factors.

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TCTAP A-157 Impaired Renal Function Is Associated with Severe Coronary Artery Disease in Chronic Stable Angina Patients

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2015.03.233 ◽

2015 ◽

Vol 65 (17) ◽

pp. S74

Author(s):

Jatindra Nath Saha ◽

Abdullah Al Shafi Majumder ◽

Nazir Ahmed Choudhury ◽

Mohammad Ullah ◽

Jafrin Jahan ◽

...

Keyword(s):

Coronary Artery Disease ◽

Renal Function ◽

Coronary Artery ◽

Stable Angina ◽

Impaired Renal Function ◽

Chronic Stable Angina ◽

Severe Coronary Artery Disease ◽

Severe Coronary Artery ◽

Artery Disease

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Platelet function test in patients with impaired renal function and coronary artery disease taking dual antiplatelet therapy

Journal of the Japanese Coronary Association ◽

10.7793/jcoron.21.15-00001 ◽

2015 ◽

Vol 21 (3) ◽

pp. 195-202

Author(s):

Yoshiki Nagata ◽

Hideki Tokuhisa ◽

Syunichiro Hondo ◽

Masaki Kinoshita ◽

Isao Aburadani ◽

...

Keyword(s):

Coronary Artery Disease ◽

Renal Function ◽

Coronary Artery ◽

Antiplatelet Therapy ◽

Platelet Function ◽

Impaired Renal Function ◽

Dual Antiplatelet Therapy ◽

Platelet Function Test ◽

Function Test ◽

Artery Disease

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Association between Endogenous Sex Hormones and Coronary Artery Disease in Postmenopausal Women

Indian Journal of Cardiovascular Disease in Women WINCARS ◽

10.1055/s-0041-1736250 ◽

2021 ◽

Author(s):

Roopali Khanna ◽

Avinash Bansal ◽

Sudeep Kumar ◽

Naveen Garg ◽

Satyendra Tewari ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Postmenopausal Women ◽

Sex Hormones ◽

Sex Hormone ◽

Vessel Disease ◽

Triple Vessel Disease ◽

Traditional Risk Factors ◽

Artery Disease

Background Incidence of coronary artery disease (CAD) increases significantly in postmenopausal women, which is assumed to be an imbalance between serum androgen and estrogen levels. However, studies assessing serum sex hormones and CAD are few and have shown conflicting results. Objective To compare serum sex hormone levels and traditional risk factors among postmenopausal women with angiographically proven CAD and without CAD. Method The study included consecutive postmenopausal women undergoing coronary angiography in our institute from May 2016 to June 2017. The clinical and coronary angiographic data and traditional risk factors were assessed. Fasting serum levels of estradiol (E2), testosterone (T), sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEA-S), and insulin were measured. Results A total of 121 postmenopausal women were included in the study; 69 were CAD and 52 without CAD. Single-vessel disease was most common (55.1%), followed by double-vessel disease (24.6%) and triple-vessel disease (20.3%). Women with CAD had significantly lower estradiol/testosterone (E2/T) ratio (3.7 ± 2.6 vs. 5.4 ± 4.2, p = 0.008) compared with non-CAD group. SHBG, DHEA-S, and insulin levels were similar in CAD and non-CAD groups. The serum level of estradiol predicted the E2/T ratio (r = 0.316, p < 0.001) and positively associated with DHEA (r = 0.181, p = 0.047). Testosterone was negatively associated with E2/T ratio (r = – 0.682, p < 0.001). There was no significant correlation of estrogen, testosterone, or E2/T ratio to lipid profile (total cholesterol, HDL, LDL) in women with CAD. Conclusion E2/T ratio was significantly lowered in postmenopausal women with CAD. E2/T ratio may be a used a predictor of CAD in postmenopausal women

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The independent and add-on values of radial intima thickness measured by ultrasound biomicroscopy for diagnosis of coronary artery disease

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez026 ◽

2019 ◽

Vol 20 (8) ◽

pp. 889-896

Author(s):

Mingjun Xu ◽

Mei Zhang ◽

Jinfeng Xu ◽

Mei Zhu ◽

Cheng Zhang ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Binary Logistic Regression ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Ultrasound Biomicroscopy ◽

Media Thickness ◽

Traditional Risk Factors ◽

Artery Disease

Abstract Aims Carotid intima-media thickness (CIMT) has been widely used to risk stratify and predict coronary artery disease (CAD) despite its significant limitations. To test whether radial artery intima thickness (RIT) is closely associated with atherosclerotic risk factors, and whether RIT has an independent and additive value for diagnosis of CAD. Methods and results One hundred and sixteen consecutive CAD patients and 79 age and gender-matched healthy controls were enrolled in this study. RIT, radial media thickness, radial intima-media thickness, and CIMT were measured with a high-resolution ultrasound biomicroscopy. Binary logistic regression was used to assess association between CAD and ultrasonic parameters, biochemical biomarkers or traditional risk factors. Receiver-operating characteristic curves were plotted to compare performances of several diagnostic models. RIT was positively associated with age, systolic blood pressure, statin administration, and hypertension. The independent value of RIT for differentiating CAD was similar to that of CIMT, but the add-on value of RIT to traditional risk factors for detecting CAD was superior to that of CIMT. Moreover, addition of RIT and CIMT to traditional risk factors increased AUC for detecting CAD from 0.724 to 0.867 significantly (P = 0.003). Conclusion RIT could detect CAD independently similarly to CIMT. The add-on value of RIT to traditional risk factors for detecting CAD was superior to CIMT and addition of RIT and CIMT to traditional risk factors markedly increased the power to diagnose CAD. Thus, RIT measured by ultrasound biomicroscopy provided a novel approach to non-invasive diagnosis of CAD.

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