W09.266 Relation between insulin resistance and traditional risk factors for coronary artery disease in obese type 2 diabetics

Background: Adipose tissue produces pro-inflammatory mediators involved in the atherosclerotic process. We investigated whether 12-month exercise training in patients with type 2 diabetes mellitus and coronary artery disease would reduce circulating levels and genetic expression of mediators in the interleukin-18, Caspase-1 and NLR pyrin domain containing 3 pathways. Correlations to glucometabolic variables; fasting glucose, HbA1c, duration of diabetes, insulin, C-peptide, insulin resistance (measured by homeostatic model assessment indexes – insulin resistance) and body mass index at baseline were further assessed. Methods: 137 patients (aged 41–81 years, 17.2% female participants) were included and randomized to a 12-month exercise programme or to a control group. Fasting blood and adipose tissue samples were taken at inclusion and after 12 months. Results: No statistically significant difference in changes of any variable between the intervention and the control group was found. At baseline, a positive correlation between insulin and homeostatic model assessment indexes – insulin resistance, interleukin-18 expression in adipose tissue and an inverse correlation between some glucometabolic variables and leukocyte expression of NLR pyrin domain containing 3 and Caspase-1 were observed. Conclusion: No significant effects of long-term exercise training were observed on the inflammasome-related mediators in our patients with combined coronary artery disease and type 2 diabetes mellitus. The observed correlations may indicate a pro-inflammatory state in adipose tissue by overweight and a compensatory downregulation of these mediators in circulating leucocytes.

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Top Three Risk Factors of Coronary Artery Disease in Chittagong, Bangladesh

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v16i1.34982 ◽

2017 ◽

Vol 16 (1) ◽

pp. 26-28

Author(s):

Abu Tarek Iqbal ◽

M Jalal Uddin ◽

Shaikh Md Hasan Mamun ◽

Rajat Sankar Roy Biswas

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Age Group ◽

Primordial Prevention ◽

Male Preponderance ◽

The Subject ◽

Artery Disease ◽

Type 2 Diabetic

Background: Many studies were conducted on the subject in home and abroad but there is none in Chittagong, Bangladesh. To know about top three risk factors for coronary artery disease we conducted the study.Methods: It was a retrospective study. Records of a private cardiac center from July 2013 to June 2014 was collected. Only coronary stenosed cases (As per angiogram) was studied. Age, sex, BMI, diabetes mellitus, hypertension, smoking and other risk factors were considered. Collected data was managed manually. Finally discussion was made and conclusion was done.Results: Majority cases 58(76%) were of 40-60 years age group. Male preponderance was there 64(83%). BMI of 45(60%) cases was normal (<25). Family history was positive among 11(14%) cases. Dyslipidemia was found in 08(10%) cases, 56(73%) cases were hypertensive, 43(56%) cases were type-2 diabetic and 35(45%) were smoker.Conclusion: Hypertension, Diabetes and Smoking are top 03 risk factors for coronary artery disease. All are modifiable. So, primordial prevention should be taken to reduce prevalence of coronary artery disease.Chatt Maa Shi Hosp Med Coll J; Vol.16 (1); Jan 2017; Page 26-28

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