Androgen Receptor Expression in the Levator Ani Muscle of Male Mice

2007 ◽  
Vol 19 (10) ◽  
pp. 823-826 ◽  
Author(s):  
J. A. Johansen ◽  
S. M. Breedlove ◽  
C. L. Jordan
Keyword(s):  
Androgen Receptor ◽  
Levator Ani ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Levator Ani Muscle ◽  
Male Mice

Estrogen, Progesterone, and Androgen Receptor Expression in Levator Ani Muscle and Fascia

2001 ◽  
Vol 10 (8) ◽  
pp. 785-795 ◽  
Author(s):  
Pleas Copas ◽  
Antonin Bukovsky ◽  
Bridgett Asbury ◽  
Robert F. Elder ◽  
Michael R. Caudle
Keyword(s):  
Androgen Receptor ◽  
Levator Ani ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Levator Ani Muscle

A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice

2008 ◽  
Vol 33 (1) ◽  
pp. 133-137 ◽  
Author(s):  
Helen E. MacLean ◽  
W. S. Maria Chiu ◽  
Cathy Ma ◽  
Julie F. McManus ◽  
Rachel A. Davey ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Serum Testosterone ◽  
Levator Ani ◽  
Androgen Receptor Gene ◽  
Levator Ani Muscle ◽  
Mrna Levels ◽  
Male Mice ◽  
Androgen Action ◽  
Floxed Allele

We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor ( AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by genotypic males lacking normal masculinization. We now report that male mice carrying the floxed allele (ARlox) have the reverse phenotype, termed hyperandrogenization. ARlox mice have increased mass of androgen-dependent tissues, including kidney, ( P < 0.001), seminal vesicle ( P < 0.001), levator ani muscle ( P = 0.001), and heart ( P < 0.05). Serum testosterone is not significantly different. Testis mass is normal, histology shows normal spermatogenesis, and ARlox males are fertile. ARlox males also have normal AR mRNA levels in kidney, brain, levator ani, liver, and testis. This study reaffirms the need to investigate the potential phenotypic effects of floxed alleles in the absence of cre in tissue-specific knockout studies. In addition, this androgen hypersensitivity model may be useful to further investigate the effects of subtle perturbations of androgen action in a range of androgen-responsive systems in the male.

Ontogeny of androgen receptor expression in spinal nucleus of the bulbocavernosus motoneurons and their target muscles in male mice

2012 ◽  
Vol 513 (2) ◽  
pp. 119-123 ◽  
Author(s):  
Milo R. Smith ◽  
Dwayne K. Hamson ◽  
Jessica E. Poort ◽  
Cynthia L. Jordan ◽  
S. Marc Breedlove
Keyword(s):  
Androgen Receptor ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Male Mice ◽  
Spinal Nucleus

Androgen receptor expression in normal, hyperplastic and neoplastic hepatoid glands in the dog

2006 ◽  
Vol 81 (2) ◽  
pp. 231-236 ◽  
Author(s):  
G. Pisani ◽  
F. Millanta ◽  
D. Lorenzi ◽  
I. Vannozzi ◽  
A. Poli
Keyword(s):  
Androgen Receptor ◽  
Receptor Expression ◽  
Androgen Receptor Expression

scholarly journals Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse

Endocrinology ◽  
2005 ◽  
Vol 146 (10) ◽  
pp. 4340-4348 ◽  
Author(s):  
Johanna S. Schneider ◽  
Carly Burgess ◽  
Nicole C. Sleiter ◽  
Lydia L. DonCarlos ◽  
John P. Lydon ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Androgen Receptor ◽  
Progesterone Receptor ◽  
Sexual Behaviors ◽  
Gene Deletion ◽  
Biological Significance ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Testicular Development ◽  
Testicular Weight

Reproductive and behavioral functions of progesterone receptors (PRs) in males were assessed by examining consequences of PR gene deletion. Basal hormone levels were measured in male progesterone receptor knockout (PRKO) mice and compared to wild-type (WT) counterparts. RIA of serum LH, testosterone, and progesterone levels revealed no significant differences. Levels of FSH were moderately but significantly lower and inhibin levels were higher in PRKOs; these differences were not accompanied by gross differences in testicular weight or morphology. PRKOs exhibited significant alterations in sexual behavior. In initial tests PRKOs exhibited reduced latency to mount, compared with WT. In second sessions, PRKOs again showed a significantly reduced latency to mount and increased likelihood of achieving ejaculation. RU486 treatment in WT produced increased mount and intromission frequency and decreased latency to intromission. In anxiety-related behavior tests, PRKO mice exhibited intermediate anxiety levels, compared with WT, suggesting that enhanced sexual behavior in PRKOs is not secondary to reduced anxiety. Immunohistochemical analysis revealed significantly enhanced androgen receptor expression in the medial preoptic nucleus and bed nucleus of the stria terminalis of PRKO. We conclude that testicular development and function and homeostatic regulation of the hypothalamic-pituitary testicular axis are altered to a lesser extent by PR gene deletion. In contrast, PR appears to play a substantial role in inhibiting the anticipatory/motivational components of male sexual behavior in the mouse. The biological significance of this inhibitory mechanism and the extent to which it is mediated by reduced androgen receptor expression remain to be clarified.

Sign in / Sign up

Export Citation Format

Share Document