Partially hydrolyzed cow’s milk formula has a therapeutic effect on the infants with mild to moderate atopic dermatitis: a randomized, double-blind study

The role of cow's milk in infantile colic in formula-fed infants was estimated in a double-blind study. Sixty colicky infants were given a cow's milk-containing formula (Enfamil) and a cow's milk-free formula based on soy (ProSobee). Eleven infants (18%) were free of symptoms while receiving soy formula. Symptoms of 32 infants (53%) were unchanged or worse when they were fed cow's milk formula and soy formula, but symptoms disappeared when they were fed a formula containing hydrolyzed casein (Nutramigen). Symptoms of 17 infants (29%) could not be related to the diet; these infants were permitted to continue on a cow's milk-based formula. A challenge with cow's milk-based formula after one month (at approximately age 3 months) produced symptoms of infantile colic in 22 infants (36%). At age 6 months, a challenge with cow's milk was positive in 11 infants (18%) with epidermal and gastrointestinal symptoms. Eight infants (13%) at 12 months of age and five infants (8%) at 16 months of age were still intolerant to cow's milk. Cow's milk seems to be a major cause of infantile colic in formula-fed infants. A dietary treatment is suggested for moderate or severe forms of the colic. Cow's milk protein intolerance is common later in infancy in these infants.

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A Partially Blind Study

PEDIATRICS ◽

10.1542/peds.71.4.667 ◽

1983 ◽

Vol 71 (4) ◽

pp. 667-668

Author(s):

BRIAN FORSYTH

Keyword(s):

Adverse Reaction ◽

Blind Study ◽

Cow’S Milk ◽

Milk Formula ◽

Double Blind Study ◽

Infantile Colic ◽

Double Blind ◽

Cow's Milk ◽

Blinded Study

To the Editor.— I would like to suggest that the article entitled: "Cow's Milk Formula as a Cause of Infantile Colic: A Double-Blind Study"1 would be better entitled: Infantile Colic and Confusion with Milk Formulas: A Partially Blinded Study. The authors of the article suggest that their results demonstrate that infantile colic was "cow's milk dependent in 71% of the infants in the study" and "53% of these infants also showed an adverse reaction to soy." With this, I disagree.

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Cow's Milk Formula and Infantile Colic

PEDIATRICS ◽

10.1542/peds.84.6.1124b ◽

1989 ◽

Vol 84 (6) ◽

pp. 1124-1125

Author(s):

WILLIAM B. CAREYMD

Keyword(s):

Milk Proteins ◽

Cow’S Milk ◽

Milk Formula ◽

Double Blind Study ◽

Milk Allergy ◽

Infantile Colic ◽

Double Blind ◽

Cow's Milk ◽

Young Infants ◽

Excessive Crying

No experienced pediatric clinician doubts the existence of cow's milk allergy in infants. The controversy concerns how often cow's milk proteins cause excessive crying or "colic" in otherwise well young infants. Three interesting papers from our colleagues in Malmö, Sweden, leave the question unanswered despite the considerable sophistication in their research design. In their first report in 1982, they concluded that in a double-blind study "cow's milk seems to be a major cause of infantile colic in formula-fed infants." However, in the only part that was double-blind, fewer infants improved while receiving soy formula (18%) than did those receiving cow's milk formula (29%).

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Faculty Opinions recommendation of A randomized double-blind study to investigate the clinical efficacy of adding a non-migrating antimicrobial to a special silk fabric in the treatment of atopic dermatitis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1120013.576136 ◽

2008 ◽

Author(s):

Arnold Oranje

Keyword(s):

Atopic Dermatitis ◽

Clinical Efficacy ◽

Blind Study ◽

Double Blind Study ◽

Silk Fabric ◽

Double Blind

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Cow’s milk exposure and atopic dermatitis after six months of age

Paediatrica Indonesiana ◽

10.14238/pi56.6.2016.325-9 ◽

2017 ◽

Vol 56 (6) ◽

pp. 325

Author(s):

Surya Jayanti Kadek ◽

Dewi Kumara Wati Ketut ◽

Karyana Putu Gede

Keyword(s):

Atopic Dermatitis ◽

Maternal Diet ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Cow’S Milk ◽

Milk Formula ◽

Sectional Study ◽

Cross Sectional ◽

Cow's Milk ◽

Study Population

Background About 60% of individuals with atopic dermatitis (AD) develop their first manifestation during infancy. Cow’s milk (CM) exposure is considered to be a risk factor for AD.Objective To evaluate for an association between cow’s milk exposure and atopic dermatitis in infants > 6 months of age. Methods This cross-sectional study consisted of subjects from a previous study and new subjects recruited in order to meet the minimum required number of subjects. Our study population comprised 120 infants, born between 1 February and 30 November, 2012 in Sanglah Hospital, Denpasar. Subjects were divided into CM and non-CM groups and analyzed for their risk of AD. Subjects were included to CM group if they were fed with cow’s milk/formula and included to non-CM group if they were breastfeed exclusively in the first six months of life. Other possible risk factors were assessed by multivariate analysis. Results One hundred twenty subjects were enrolled and analyzed (59 in the CM and 61 in the non-CM groups). The prevalence of AD was 30%. Multiple logistic regression analysis revealed a significant association between CM exposure and AD, with odds ratio (OR) 2.37 (95%CI 1.036 to 5.420; P=0.04). In addition, maternal diet including eggs and/or cow’s milk during the breastfeeding period was significantly associated with AD in infants (OR 3.18; 95%CI 1.073 to 9.427; P=0.04).Conclusion Cow’s milk exposure is significantly associated with atopic dermatitis in infants > six months of age.

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A Partially Blind Study

PEDIATRICS ◽

10.1542/peds.71.4.668 ◽

1983 ◽

Vol 71 (4) ◽

pp. 668-668

Author(s):

L. LOTHE ◽

T. LINDBERG ◽

I. JAKOBSSON

Keyword(s):

Blind Study ◽

Cow’S Milk ◽

Infantile Colic ◽

Double Blind ◽

Blind Test ◽

Cow's Milk

In Reply.— In reply to Forsyth we want to refer to our recent publication in this journal. Once again we emphasize that our conclusion that cow's milk seems to be one major factor in causing infantile colic is based on the results of the whole study (ie, not only the double-blind test, but also the outcome of the cow's milk challenges at follow-up). Concerning the 18% (11 infants) who did not react adversely to soy formula, seven infants received it as the first challenge and four as the second.

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