scholarly journals Molecular characterization of flayanone 3beta-hydroxylases. Consensus sequence, comparison with related enzymes and the role of conserved histidine residues

1993 ◽  
Vol 217 (2) ◽  
pp. 753-754
Author(s):  
Lothar BRITSCH ◽  
Jurgen DEDIO ◽  
Heinz SAEDLER ◽  
Gert FORKMANN
Keyword(s):  
Molecular Characterization ◽  
Sequence Comparison ◽  
Consensus Sequence ◽  
Histidine Residues

PHYSIOLOGIC AND MOLECULAR CHARACTERIZATION OF THE ROLE OF NITRIC OXIDE IN HEMORRHAGIC SHOCK

Shock ◽  
1997 ◽  
Vol 7 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Edward Kelly ◽  
Nishit S. Shah ◽  
Nathan N. Morgan ◽  
Simon C. Watkins ◽  
Andrew B. Peitzman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hemorrhagic Shock ◽  
Molecular Characterization

scholarly journals Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Blood ◽  
2015 ◽  
Vol 125 (22) ◽  
pp. 3388-3392 ◽  
Author(s):  
Olli Silvennoinen ◽  
Stevan R. Hubbard
Keyword(s):  
Molecular Characterization ◽  
Human Disease ◽  
Molecular Mechanisms ◽  
Myeloproliferative Neoplasms ◽  
Critical Role ◽  
Hematologic Malignancies ◽  
Janus Kinase ◽  
Constitutive Activation

Abstract The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revolutionized the diagnostics of MPNs and led to development of novel JAK2 therapeutics. However, the molecular mechanisms by which mutations in the pseudokinase domain lead to hyperactivation of JAK2 and clinical disease have been unclear. Here, we describe recent advances in the molecular characterization of the JAK2 pseudokinase domain and how pathogenic mutations lead to constitutive activation of JAK2.

scholarly journals Molecular characterization of MRSA isolates bracketing the current EUCAST ceftaroline-susceptible breakpoint forStaphylococcus aureus: the role of PBP2a in the activity of ceftaroline

2015 ◽  
Vol 70 (9) ◽  
pp. 2488-2498 ◽  
Author(s):  
Sushmita D. Lahiri ◽  
Robert E. McLaughlin ◽  
James D. Whiteaker ◽  
Jane E. Ambler ◽  
Richard A. Alm
Keyword(s):  
Molecular Characterization

Differential targeting of cPKC and nPKC decodes and regulates Ca2+ and lipid signalling

2014 ◽  
Vol 42 (6) ◽  
pp. 1538-1542 ◽  
Author(s):  
Xin Hui ◽  
Lars Kaestner ◽  
Peter Lipp
Keyword(s):  
Protein Kinases ◽  
Consensus Sequence ◽  
Membrane Targeting ◽  
Cellular Processes ◽  
Lipid Signalling ◽  
Pkc Isoforms

Protein kinases C (PKCs) are ubiquitously expressed and play critical roles in a plethora of physiological and pathophysiological processes. Owing to PKCs’ highly conserved phosphorylation consensus sequence, it has been difficult to distinguish the role of individual PKC isoforms. Recently, the identification of novel membrane targeting via subcellularly targeted diacylglycerol production found for novel PKCs (nPKCs), together with a characterization of their putative functions, has shed new light on the specific roles of individual PKCs in cellular processes.

scholarly journals Molecular characterization of Kv2.1 channels in sheep vasculature: Role of Kv channels in regulating vascular tone

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
K Dinesh ◽  
S Hirenallur ◽  
Avinash G Telang ◽  
Santhosh K Mishra
Keyword(s):  
Molecular Characterization ◽  
Vascular Tone ◽  
Kv Channels

scholarly journals Molecular characterization and pathogenicity of isolates of Beauveria spp. to fall armyworm

2008 ◽  
Vol 43 (4) ◽  
pp. 513-520 ◽  
Author(s):  
Andréa Almeida Carneiro ◽  
Eliane Aparecida Gomes ◽  
Claudia Teixeira Guimarães ◽  
Fernando Tavares Fernandes ◽  
Newton Portilho Carneiro ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Spodoptera Frugiperda ◽  
Sequence Comparison ◽  
Rapd Markers ◽  
Fall Armyworm ◽  
Its Sequence ◽  
Its Sequencing ◽  
Host Insect ◽  
Rdna Its

The objective of this work was to evaluate the pathogenicity of 24 Beauveria isolates to Spodoptera frugiperda larvae, and characterize them molecularly through rDNA-ITS sequencing and RAPD markers. Sequencing of rDNA-ITS fragments of 570 bp allowed the identification of isolates as B. bassiana or B. brongniarti by sequence comparison to GenBank. Sixty seven polymorphic RAPD fragments were capable to differentiate 20 among 24 Beauveria isolates, grouping them according to the derived host insect and to pathogenicity against maize fall armyworm larvae. Three RAPD markers were highly associated to the pathogenicity against S. frugiperda, explaining up to 67% of the phenotypic variation. Besides identification and molecular characterization of Beauveria isolates, ITS sequence and RAPD markers proved to be very useful in selecting the isolates potentially effective against S. frugiperda larvae and in monitoring field release of these microorganisms in biocontrol programs.

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