Differential Expression of Connexin 43 in Adult Pig Testes During Normal Spermatogenic Cycle and After Flutamide Treatment

2011 ◽  
Vol 46 (6) ◽  
pp. 1050-1060 ◽  
Author(s):  
I Kopera ◽  
M Durlej ◽  
A Hejmej ◽  
K Knapczyk-Stwora ◽  
M Duda ◽  
...  
1999 ◽  
Vol 84 (5) ◽  
pp. 1705-1710 ◽  
Author(s):  
Colette Sparey ◽  
Stephen C. Robson ◽  
Jarrod Bailey ◽  
Fiona Lyall ◽  
G. Nicholas Europe-Finner

There is evidence from many studies indicating that a number of specific quiescent and contractile associated proteins are temporally regulated in the myometrium during pregnancy. In this present investigation we provide data that strongly suggest that myometrial connexin-43, cyclooxygenase-1 and -2 (COX-1 and -2), and Gsα proteins are also spatially expressed within the human uterus during pregnancy and labor. Using paired lower and upper segment myometrial samples taken from individual women at term and during spontaneous labor, we have measured the expression of these proteins by immunoblotting with specific antibodies. We report that the myometrial gap junction connexin-43 protein is expressed at much greater levels in the upper uterine compared to the lower uterine segment and that this difference is even more pronounced during the course of labor. Conversely, myometrial COX-1 and -2 proteins appear to be expressed at much greater levels in the lower compared to the upper uterine segment. Moreover, the level of expression of both proteins is unaffected by the onset of parturition. In contrast, myometrial Gsα protein appears to be uniformly expressed in both lower and upper segments and is similarly down-regulated during parturition, as previously reported. The differential expression of COX-1 and -2 and connexin-43 in the uterus may allow cervical ripening before and dilatation during labor and facilitate effective propagation of contractions from fundus to cervix, which may be further facilitated by the down-regulation of Gsα at the onset of parturition.


2005 ◽  
Vol 206 (4) ◽  
pp. 377-382 ◽  
Author(s):  
Akiko Nishitani ◽  
Seiichi Hirota ◽  
Toshirou Nishida ◽  
Koji Isozaki ◽  
Keiko Hashimoto ◽  
...  

2003 ◽  
Vol 71 (5) ◽  
pp. 617-628 ◽  
Author(s):  
Anastas Popratiloff ◽  
Seth M. Pollack ◽  
Christian Giaume ◽  
Kenna D. Peusner

2006 ◽  
Vol 30 (5) ◽  
pp. 472-479 ◽  
Author(s):  
T LAMBE ◽  
D FINLAY ◽  
M MURPHY ◽  
F MARTIN

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 477-477
Author(s):  
Timothy J. Morschauser ◽  
Jayanth Ramadoss ◽  
Jill M. Koch ◽  
Gladys E. Lopez ◽  
Ian M. Bird ◽  
...  

2008 ◽  
Vol 104 (1-3) ◽  
pp. 127-134 ◽  
Author(s):  
S. Hossein Fatemi ◽  
Timothy D. Folsom ◽  
Teri J. Reutiman ◽  
Twinkle Pandian ◽  
Natalie N. Braun ◽  
...  

2010 ◽  
Vol 112 (3) ◽  
pp. 278-283 ◽  
Author(s):  
Xiao-yan Jiang ◽  
Xiao-hong Feng ◽  
Guo-yan Li ◽  
Qian Zhao ◽  
Hui-qing Yin

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