scholarly journals Growth and Morphogenesis of Embryonic Mouse Organs on Non-Coated and Extracellular Matrix-Coated Biopore Membrane. (organ-culture/growth/morphogenesis/extracellular matrix/Biopore)

1993 ◽  
Vol 35 (6) ◽  
pp. 683-690 ◽  
Author(s):  
Patricia Hardman ◽  
Brenda J. Klement ◽  
Brian S. Spooner
Keyword(s):  
Extracellular Matrix ◽  
Organ Culture ◽  
Embryonic Mouse ◽  
Culture Growth

Effect of Vitamin C Plus Reducing Agents on Production of Cartilage by Embryonic Mouse Radii Grown in Organ Culture

1970 ◽  
Vol 5 (4) ◽  
pp. 282
Author(s):  
Henry H. Jones ◽  
Margaret McHardy-Young ◽  
James Breeden ◽  
Geraldine Gribble
Keyword(s):  
Vitamin C ◽  
Organ Culture ◽  
Reducing Agents ◽  
Embryonic Mouse

scholarly journals Extracellular matrix-inducing Sox9 orchestrates basal progenitor proliferation and gliogenesis in developing neocortex

2019 ◽  
Author(s):  
Ayse Güven ◽  
Denise Stenzel ◽  
Katherine R. Long ◽  
Marta Florio ◽  
Holger Brandl ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Fate ◽  
Subventricular Zone ◽  
Integrin Signaling ◽  
Sox9 Expression ◽  
Embryonic Mouse ◽  
Functional Studies ◽  
Basal Progenitor ◽  
Developing Neocortex ◽  
Stimulation Of

AbstractNeocortex expansion is largely based on the proliferative capacity of basal progenitors (BPs), which is increased by extracellular matrix (ECM) components via integrin signaling. Here we show that Sox9 drives expression of ECM components and that laminin 211 increases BP proliferation in embryonic mouse neocortex. Examination of Sox9 expression reveals that Sox9 is expressed in BPs of developing ferret and human, but not mouse neocortex. Functional studies by conditional Sox9 expression in the mouse BP lineage demonstrate increased BP proliferation, reduced Tbr2 and induction of Olig2 expression, indicative of premature gliogenesis. Conditional Sox9 expression also results in cell non-autonomous stimulation of BP proliferation followed by increased production of upper-layer neurons. Collectively, our findings demonstrate that Sox9 exerts concerted effects on transcription, BP proliferation, neuron production, and neurogenic as well as gliogenic BP cell fate, suggesting that Sox9 acts a master regulator in the subventricular zone to promote neocortical expansion.

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