Distribution and regulation of L-type calcium channels in deep dorsal horn neurons after sciatic nerve injury in rats

2005 ◽  
Vol 21 (12) ◽  
pp. 3321-3333 ◽  
Author(s):  
E. Dobremez ◽  
R. Bouali-Benazzouz ◽  
P. Fossat ◽  
L. Monteils ◽  
J. Dulluc ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Calcium Channels ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Dorsal Horn Neurons

Complement and clusterin in the spinal cord dorsal horn and gracile nucleus following sciatic nerve injury in the adult rat

Neuroscience ◽  
1995 ◽  
Vol 68 (1) ◽  
pp. 167-179 ◽  
Author(s):  
L. Liu ◽  
E. To¨rnqvist ◽  
P. Mattsson ◽  
N.P. Eriksson ◽  
J.K.E. Persson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Sciatic Nerve Injury ◽  
Spinal Cord Dorsal Horn ◽  
Adult Rat ◽  
Gracile Nucleus ◽  
Spinal Cord Dorsal

scholarly journals High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury

2015 ◽  
Vol 113 (5) ◽  
pp. 1511-1519 ◽  
Author(s):  
Swetha S. Murali ◽  
Ian A. Napier ◽  
Sarasa A. Mohammadi ◽  
Paul F. Alewood ◽  
Richard J. Lewis ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
High Voltage ◽  
Large Diameter ◽  
Membrane Excitability ◽  
Drg Neurons ◽  
Dorsal Horn Neurons ◽  
Whole Cell Patch Clamp

Changes in ion channel function and expression are characteristic of neuropathic pain. Voltage-gated calcium channels (VGCCs) are integral for neurotransmission and membrane excitability, but relatively little is known about changes in their expression after nerve injury. In this study, we investigate whether peripheral nerve ligation is followed by changes in the density and proportion of high-voltage-activated (HVA) VGCC current subtypes in dorsal root ganglion (DRG) neurons, the contribution of presynaptic N-type calcium channels in evoked excitatory postsynaptic currents (EPSCs) recorded from dorsal horn neurons in the spinal cord, and the changes in expression of mRNA encoding VGCC subunits in DRG neurons. Using C57BL/6 mice [8- to 11-wk-old males ( n = 91)] for partial sciatic nerve ligation or sham surgery, we performed whole cell patch-clamp recordings on isolated DRG neurons and dorsal horn neurons and measured the expression of all VGCC subunits with RT-PCR in DRG neurons. After nerve injury, the density of P/Q-type current was reduced overall in DRG neurons. There was an increase in the percentage of N-type and a decrease in that of P/Q-type current in medium- to large-diameter neurons. No changes were found in the contribution of presynaptic N-type calcium channels in evoked EPSCs recorded from dorsal horn neurons. The α2δ-1 subunit was upregulated by 1.7-fold and γ-3, γ-2, and β-4 subunits were all downregulated 1.7-fold in injured neurons compared with sham-operated neurons. This comprehensive characterization of HVA VGCC subtypes in mouse DRG neurons after nerve injury revealed changes in N- and P/Q-type current proportions only in medium- to large-diameter neurons.

Spinal cord stimulation induces c-Fos expression in the dorsal horn in rats with neuropathic pain after partial sciatic nerve injury

2009 ◽  
Vol 450 (1) ◽  
pp. 70-73 ◽  
Author(s):  
Helwin Smits ◽  
Maarten V. Kleef ◽  
Wiel Honig ◽  
Job Gerver ◽  
Philipp Gobrecht ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Spinal Cord Stimulation ◽  
Sciatic Nerve Injury ◽  
Fos Expression

Gene expression profile changes in rat dorsal horn after sciatic nerve injury

2016 ◽  
Vol 39 (2) ◽  
pp. 176-182 ◽  
Author(s):  
Jing Wang ◽  
Song-He Ma ◽  
Rong Tao ◽  
Ling-Jie Xia ◽  
Lin Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sciatic Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Sciatic Nerve Injury ◽  
Profile Changes
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