Reduced bladder cancer recurrence rate with cardioprotective aspirin after intravesical bacille Calmette-Guérin

Abstract Urinary bladder cancer is a common cancer worldwide. Currently, the modality of treating and monitoring bladder cancer is wide. Nonetheless, the high recurrence rate of non-muscle-invasive bladder cancer after surgical resection is still unsatisfactory. Hereby, our study demonstrated whether the intra-operative and post-operative environments will affect bladder cancer recurrence utilizing in vitro cell line model. Bladder cancer cell lines were submerged in four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water performed the best in terms of the magnitude of cytotoxicity to cell lines. Besides, we also investigated cytotoxic effects of the four irrigating agents as well as mitomycin C (MMC) in normothermic and hyperthermic conditions. We observed that sterile water and MMC had an increased cytotoxic effects to bladder cancer cell lines in hyperthermic conditions. Altogether, our results could be translated into clinical practice in the future by manipulating the intra-operative and post-operative conditions in order to lower the chance of residual cancer cell reimplant onto the bladder, which in turns, reducing the recurrence rate of bladder cancers.

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STAG2 Coupled With p53 Alteration Has a Significant Impact on Bladder Cancer Recurrence and Progression

10.21203/rs.2.13677/v1 ◽

2019 ◽

Author(s):

Jiangchuan Chen ◽

Zhigang Xu ◽

Xiao-Dong Meng ◽

Jie Li ◽

Yin Chen

Keyword(s):

Bladder Cancer ◽

Recurrence Rate ◽

Bladder Tumor ◽

Unmet Need ◽

Cancer Recurrence ◽

P53 Mutation ◽

Pelvic Lymphadenectomy ◽

Prediction Of Survival ◽

P53 Status ◽

Bladder Cancer Recurrence

Abstract Background:There is an unmet need for additional biomarkers for stratifying tumors based on their risk of recurrence and progression. Stromal antigen 2 (STAG2) and p53 are the most common mutations in bladder cancer and their association with the prognosis of bladder cancer remains unclear.Methods:Patients were divided into two cohorts according to stage and surgical procedure. The value of combined STAG2 expression (+/-) and P53 mutation (+/-) was evaluated for prediction of recurrence in 334 patients diagnosed by transurethral resection of bladder tumor (TURBT) and for prediction of survival in 144 patients who underwent radical cystectomy and pelvic lymphadenectomy( RCPLT).Results:We found that,in the 334 TURBT-treated patients, recurrence rate was significantly greater for STAG2(+) tumors than STAG2(-) tumors (73.5% vs. 55.0%, P=0.001). Of 144 RCPLT-treated patients, 127 (88.2%) were STAG2(+), of which 71 (55.9%) survived 5 years, compared to none of the 17 STAG2(-) patients. Patients with combined STAG2(+)/P53 mutation(+) tumors had the highest recurrence rate (83.5%) while patients with STAG2(-)/P53(-) tumors had the lowest recurrence rate (50%). Patients with STAG2(+)/P53(-) tumors achieved the highest 5-year survival rate (69.7%). Systemic chemotherapy did not improve prognosis of RCPLT-treated patients, but appeared to benefit STAG2(-) patients.Conclusions: Our results suggest that combined STAG2 expression and P53 status is a valuable biomarker for BCa prognosis, accurately predicting recurrence in TURBT-treated patients. STAG2(+)/P53(-) predicted a higher five-year survival and STAG2(-) predicted low five-year survival in RCPLT-treated patients. Chemotherapy may interfere with this predictive efficacy, especially in STAG2(-) patients.

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In vitro assessment of intra-operative and post-operative environment in reducing bladder cancer recurrence

Scientific Reports ◽

10.1038/s41598-021-04035-8 ◽

2022 ◽

Vol 12 (1) ◽

Author(s):

Ryan Tsz-Hei Tse ◽

Hongda Zhao ◽

Christine Yim-Ping Wong ◽

Angel Wing-Yan Kong ◽

Ronald Cheong-Kin Chan ◽

...

Keyword(s):

Bladder Cancer ◽

Recurrence Rate ◽

Cell Lines ◽

Cancer Cell ◽

Cancer Recurrence ◽

Cancer Cell Lines ◽

Bladder Cancer Cell ◽

Sterile Water ◽

Bladder Cancer Recurrence

AbstractUrinary bladder cancer is a common cancer worldwide. Currently, the modality of treating and monitoring bladder cancer is wide. Nonetheless, the high recurrence rate of non-muscle-invasive bladder cancer after surgical resection is still unsatisfactory. Hereby, our study demonstrated whether the intra-operative and post-operative environments will affect bladder cancer recurrence utilizing in vitro cell line model. Bladder cancer cell lines were submerged in four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water performed the best in terms of the magnitude of cytotoxicity to cell lines. Besides, we also investigated cytotoxic effects of the four irrigating agents as well as mitomycin C (MMC) in normothermic and hyperthermic conditions. We observed that sterile water and MMC had an increased cytotoxic effect to bladder cancer cell lines in hyperthermic conditions. Altogether, our results could be translated into clinical practice in the future by manipulating the intra-operative and post-operative conditions in order to lower the chance of residual cancer cells reimplant onto the bladder, which in turns, reducing the recurrence rate of bladder cancers.

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238: Combined Effect of Apoptotic Biomarkers on Bladder Cancer Recurrence and Mortality after Radical Cystectomy

The Journal of Urology ◽

10.1016/s0022-5347(18)30503-2 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 79-80

Author(s):

Jose A. Karam ◽

Yair Lotan ◽

Raheela Ashfaq ◽

Claus G. Roehrborn ◽

Arthur I. Sagalowsky ◽

...

Keyword(s):

Bladder Cancer ◽

Radical Cystectomy ◽

Cancer Recurrence ◽

Combined Effect ◽

Bladder Cancer Recurrence

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Faculty Opinions recommendation of Predicting nonmuscle invasive bladder cancer recurrence and progression in patients treated with bacillus Calmette-Guerin: the CUETO scoring model.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3246962.2931060 ◽

2010 ◽

Author(s):

Juan Palou Redorta ◽

Guillermo Urdaneta

Keyword(s):

Bladder Cancer ◽

Cancer Recurrence ◽

Invasive Bladder Cancer ◽

Bacillus Calmette Guerin ◽

Scoring Model ◽

Bladder Cancer Recurrence ◽

Nonmuscle Invasive Bladder Cancer

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En bloc transurethral resection of bladder tumor: A review of the literature

Journal of Clinical Urology ◽

10.1177/2051415821993734 ◽

2021 ◽

pp. 205141582199373

Author(s):

Jonathan Kopel ◽

Pranav Sharma

Keyword(s):

Bladder Cancer ◽

Transurethral Resection ◽

Bladder Tumor ◽

Clinical Stage ◽

Surgical Techniques ◽

Cancer Recurrence ◽

En Bloc ◽

Level Of Evidence ◽

Alternative Technologies ◽

Bladder Cancer Recurrence

Bladder cancer remains one of the most common malignancies of the genitourinary tract. Transurethral resection of the bladder tumor (TURBT) via cystoscopy with examination under anesthesia remains the primary method for determining the diagnosis and clinical stage of bladder cancer. Given the substantial cost of treatment and risk of bladder cancer recurrence after TURBT, novel approaches to transurethral resection, such as the en bloc technique, have been developed in an attempt to address these limitations. In this review, we examined the postoperative and oncological outcomes of en bloc TURBT compared to traditional resection techniques. Further prospective clinical studies, however, are still necessary to determine whether these alternative technologies or surgical techniques may improve treatment in bladder cancer patients. Level of evidence: Not applicable.

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