Effect of Serotonin on Regional Cerebral Blood Flow (rCBF) in Man

Cephalalgia ◽  
1981 ◽  
Vol 1 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Jes Olesen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Cerebral Hemisphere ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Constant Infusion ◽  
Regional Cerebral Blood ◽  
The Difference

With the intraarterial 133Xenon injection method, regional cerebral blood flow (rCBF) was measured from 35 regions of a cerebral hemisphere. The effect of a constant infusion of serotonin (10–33 μg/min) for 2–5 min into the internal carotid artery was studied eight times in five patients. During rest, mean rCBF was 43.5 ml/100g/min as compared to 42.6 ml/100g/min during serotonin infusion. The latter value was altered to 42.8 ml/100g/min if correction for altered PaCO2 was carried out. In neither instance was the difference significant. It is concluded that circulating serotonin is unlikely to cause the cerebrovascular alterations associated with classical migraine attacks.

Impact of transient hypotension on regional cerebral blood flow in humans

2015 ◽  
Vol 129 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Nia C.S. Lewis ◽  
Kurt J. Smith ◽  
Anthony R. Bain ◽  
Kevin W. Wildfong ◽  
Tianne Numan ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Vertebral Artery ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Regional Cerebral Blood

Diameter reductions in the internal carotid artery (ICA) and vertebral artery (VA) contribute to the decline in brain blood with hypotension. The decline in vertebral blood flow with hypotension was greater when carbon dioxide was low; this was not apparent in the ICA.

Augmenting Regional Cerebral Blood Flow Using External-to-Internal Carotid Artery Flow Diversion Method

2009 ◽  
Vol 37 (12) ◽  
pp. 2428-2435 ◽  
Author(s):  
Afshin A. Divani ◽  
Tamara L. Berezina ◽  
Gabriela Vazquez ◽  
Sergey B. Zaets ◽  
Ramachandra Tummala ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Flow Diversion ◽  
Regional Cerebral Blood ◽  
Artery Flow

scholarly journals Intraoperative Regional Cerebral Blood Flow During Carotid Endarterectomy

1981 ◽  
Vol 8 (3) ◽  
pp. 235-241 ◽  
Author(s):  
David W. Rowed ◽  
Miklos I. Vilaghy
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Neurological Deficit ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Regional Cerebral Blood ◽  
Stump Pressure ◽  
Probe Holder

SUMMARY:Regional cerebral blood flow (rCBF) during internal carotid artery (ICA) occlusion for endarterectomy can be measured without inconvenience using the probe holder illustrated.When mean ipsilateral hemispheric CBF exceeds 20 ml/100 gm/min, an intraluminal bypass is not necessary (63% of patients), except in patients with extensive cerebrovascular disease in whom rCBF should also exceed 20 ml/100 gm/min in all areas. ICA “stump” pressure is falsely high in about 20% of patients, and is therefore not a dependable criterion for selecting patients who need shunting.While intraoperative shunting is capable of restoring pre-occlusion CBF levels, it does not eliminate the risk of intraoperative ischemic neurological deficit of probable embolic origin.

scholarly journals Retraction of the Internal Carotid Artery and Measurement of the Regional Cerebral Blood Flow in Basilar Top Aneurysmal Surgery

1991 ◽  
Vol 19 (3) ◽  
pp. 348-352
Author(s):  
Shuichi OKI ◽  
Toshinori NAKAHARA ◽  
Zainal MUTTAQIN ◽  
Yoshio TOKUDA ◽  
Katsuya EMOTO ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Regional Cerebral Blood Flow ◽  
Internal Carotid ◽  
Regional Cerebral Blood

scholarly journals Angiographic Circulation Time and Cerebral Blood Flow during Balloon Test Occlusion of the Internal Carotid Artery

2013 ◽  
Vol 34 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Kenichi Sato ◽  
Hiroaki Shimizu ◽  
Takashi Inoue ◽  
Miki Fujimura ◽  
Yasushi Matsumoto ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Circulation Time ◽  
Emission Computed Tomography ◽  
Bilateral Asymmetry ◽  
Balloon Test Occlusion ◽  
The Difference

Angiography-based balloon test occlusion (BTO) has been empirically used to predict tolerance to permanent carotid artery occlusion. We tested the hypothesis that the laterality of the hemispheric circulation time (HCT) of the contrast medium at cerebral angiography would reflect bilateral asymmetry of the cerebral blood flow (CBF) during BTO. Thirty-one consecutive patients who underwent BTO of the internal carotid artery were retrospectively analyzed. HCT was defined as the interval between the time-to-peak in the middle cerebral artery and the cortical veins calculated using time-density curve. The difference in HCT between the occluded and nonoccluded side was calculated at the carotid or dominant vertebral angiograms obtained during BTO. We estimated the correlation between the difference in HCT and bilateral asymmetry of the CBF, which was quantitatively determined by single-photon emission computed tomography. The HCT was 5.3±1.5 seconds and regional CBF was 41.3±11.3 mL/100 g per minute in the occluded side, compared with 3.6±0.9 seconds and 48.4±14.9 mL/100 g per minute in the nonoccluded side, respectively. The difference in HCT was strongly correlated with the asymmetry ratio of the CBF ( r2=0.89, P<0.0001). Angiographically based measurement of the cerebral circulation time can provide valuable information concerning cerebral hemodynamics.

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