Raised Plasma Endothelin During Acute Migraine Attack
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The Mean
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Endothelins are the most potent vasoconstrictor peptides known. Plasma endothelin (ET-1) concentrations were measured in eight migraine patients (mean age 44.5 years), two during an acute migraine attack with aura and six during an attack without aura. The mean ET-1 values were elevated in all migraine patients above the range of normal subjects, and were 10.6 (range 6.0–16.0) pg/ml in migraine patients and 3.8 (range 0.7–5.8) pg/ml in controls. We hypothesize that ET-1 may constrict cerebral vessels during the initial stage of the migraine attack.
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1992 ◽
Vol 32
(2)
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pp. 98-100
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2006 ◽
Vol 46
(6)
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pp. 942-953
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