Migraine and Antiphospholipid Antibodies: No Association Found in Migraine-Discordant Monozygotic Twins

Cephalalgia ◽  
2008 ◽  
Vol 28 (10) ◽  
pp. 1048-1052 ◽  
Author(s):  
FMK Williams ◽  
LF Cherkas ◽  
ML Bertolaccini ◽  
V Murru ◽  
GL Surdulescu ◽  
...  
Keyword(s):  
General Population ◽  
Antiphospholipid Antibodies ◽  
Migraine Headache ◽  
Pregnancy Loss ◽  
Natural Experiment ◽  
Genetic Factors ◽  
Monozygotic Twins ◽  
Anticardiolipin Antibody ◽  
Mz Twins

Migraine headache (with and without aura) is common in the general population and is known to be influenced by genetic factors with heritability estimates between 34-57±. Antiphospholipid syndrome (APS) is a hypercoagulable state characterized by clinical features including venous and arterial thromboses, pregnancy loss and migraine, and by association with antiphospholipid antibodies (aPL). Numerous small studies have investigated whether aPL are associated with migraine in the general population—-with contradictory results. In this study, the question was addressed by studying the prevalence of aPL in members of monozygotic (MZ) twin pairs differing in their migraine status. Such twins provide a unique natural experiment, matched as they are for age, sex and genetic factors, and allow the role of environmental factors, such as aPL, to be determined. Despite 95± power to detect a difference of 0.59 IgG units per litre in anticardiolipin antibody IgG titres, no difference in prevalence of aPL could be detected in migraine-discordant MZ twins.

Role of male genetic factors in recurrent pregnancy loss in Northeast China

2018 ◽  
Vol 224 ◽  
pp. 6-11 ◽  
Author(s):  
Rulin Dai ◽  
Yuan Pan ◽  
Yan Fu ◽  
Qian Liu ◽  
Weifeng Han ◽  
...  
Keyword(s):  
Northeast China ◽  
Pregnancy Loss ◽  
Genetic Factors ◽  
Recurrent Pregnancy Loss

Migraine and Antiphospholipid Antibodies

Cephalalgia ◽  
1992 ◽  
Vol 12 (2) ◽  
pp. 69-74 ◽  
Author(s):  
Gretchen E Tietjen
Keyword(s):  
Antiphospholipid Antibodies ◽  
Migraine Headache ◽  
Migraine Aura ◽  
Neurologic Symptoms ◽  
Actual Role

Migraine and antiphospholipid antibodies. Cephalalgia 1992:12:69–74. Antiphospholipid antibodies have been detected in patients with transient neurologic symptoms including migraine aura. The role of these antibodies in the pathogenesis of migraine is not fully understood. The available data suggest an association between the migraine-like phenomena and antiphospholipid antibodies, but not between migraine headache and antiphospholipid antibodies. To elucidate the actual role of antiphospholipid antibodies in migraine, prospective, controlled studies are needed.

scholarly journals The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss

2002 ◽  
Vol 51 (2) ◽  
pp. 18-22
Author(s):  
O. N. Arzhanova ◽  
T. N. Shliakhtenko ◽  
S. А. Selkov ◽  
T. А. Pluzhnikova ◽  
О. V. Tishkevitch ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Perinatal Mortality ◽  
Antiphospholipid Antibodies ◽  
Preterm Labor ◽  
Pregnancy Loss ◽  
Control Group ◽  
Threatened Abortion ◽  
Immunofluorescent Analysis ◽  
Present Pregnancy

Clinical and anamnesis analysis as well as analysis of the course and outcome of the present pregnancy was performed on 595 patients with complicated obstetrical and gynecological history (COGH) habitual pregnancy loss, infertility, genital chronic processes. Control groupconsisted of 5O healthy women. Immunofluorescent analysis was used to reved antiphospholipid antibodies on blood plasma. Antiphospholipid antibodies were found in 42% of COGH women. No antiphospholipid antibodies were seen in the control group. In all patients of the studied groupthe course of pregnancy was accompanied with signs of threatened abortion, gestosis. 29% (p O, O1) patients had preterm labor and spontaneous abortion occurred in 18% (p O, O1) of cases. Perinatal mortality was 9, 8%4, 16.

scholarly journals Parental depression and offspring psychopathology: a Children of Twins study

2010 ◽  
Vol 41 (7) ◽  
pp. 1385-1395 ◽  
Author(s):  
A. L. Singh ◽  
B. M. D'Onofrio ◽  
W. S. Slutske ◽  
E. Turkheimer ◽  
R. E. Emery ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Parental Depression ◽  
Structured Interview ◽  
Disruptive Disorders ◽  
Children Of Twins ◽  
History Of ◽  
Mz Twins ◽  
History Of Depression ◽  
Shared Genetic

BackgroundAssociations between parental depression and offspring affective and disruptive disorders are well documented. Few genetically informed studies have explored the processes underlying intergenerational associations.MethodA semi-structured interview assessing DSM-III-R psychiatric disorders was administered to twins (n=1296) from the Australian Twin Register (ATR), their spouses (n=1046) and offspring (n=2555). We used the Children of Twins (CoT) design to delineate the extent to which intergenerational associations were consistent with a causal influence or due to genetic confounds.ResultsIn between-family analyses, parental depression was associated significantly with offspring depression [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.20–1.93] and conduct disorder (CD; HR 2.27, CI 1.31–3.93). Survival analysis indicated that the intergenerational transmission of depression is consistent with a causal (environmental) inference, with a significant intergenerational association in offspring of discordant monozygotic (MZ) twin pairs (HR 1.39, CI 1.00–1.94). Logistic regression analysis suggested that the parental depression–offspring CD association was due to shared genetic liability in the parents and offspring. No intergenerational association was found when comparing the offspring of discordant MZ twins [odds ratio (OR) 1.41, CI 0.63–3.14], but offspring of discordant dizygotic (DZ) twins differed in their rates of CD (OR 2.53, CI 0.95–6.76). All findings remained after controlling for several measured covariates, including history of depression and CD in the twins' spouses.ConclusionsThe mechanisms underlying associations between parental depression and offspring psychopathology seem to differ depending on the outcome. The results are consistent with a causal environmental role of parental depression in offspring depression whereas common genetic factors account for the association of parental depression and offspring CD.

Heredity of Twinning in Families of Monozygotic Twins

1976 ◽  
Vol 25 (1) ◽  
pp. 70-72
Author(s):  
L. Gedda ◽  
O. Russo ◽  
M. Capone
Keyword(s):  
Genetic Factor ◽  
Genetic Factors ◽  
A Priori ◽  
Monozygotic Twins ◽  
Mz Twins

Whereas the existence of some genetic factor underlying the phenomenon of twinning is almost generally accepted with respect to DZ twins, no such agreement exists with respect to MZ twins. The possible existence of genetic factors underlying MZ twinning has been verified through an analysis of segregation in the sibships of MZ twins and in those of their parents, carried out on a sample of 57 MZ twin pairs (30 M and 27 F). Haldane's a priori method has been applied, considering the sample as obtained through a complete and through an incomplete ascertainment. The results may lead to cautiously confirm the hypothesis of some genetic conditioning of MZ twinning.

Synchronous Onset of Secondary Raynaud's Phenomenon in Monozygotic Twins

2012 ◽  
Vol 10 (3) ◽  
pp. 535-537 ◽  
Author(s):  
A. Riccio ◽  
M.G. Sangiolo ◽  
G. Tarantino
Keyword(s):  
Genetic Factors ◽  
Raynaud’S Phenomenon ◽  
Monozygotic Twins ◽  
Raynaud's Phenomenon ◽  
Primary Raynaud’S Phenomenon ◽  
Secondary Raynaud’S Phenomenon

The heritability of primary Raynaud's phenomenon has been reported in previous works. In this paper we describe the simultaneous onset of Raynaud's phenomenon, rapidly evolved in acrocyanosis and diagnosed as secondary Raynaud's phenomenon, observed in monozygotic twins. This case supports the role of genetic factors in the pathogenesis of such disorder. Moreover, the singular synchronism of its appearance is discussed.

Concordant primary atrophy of the cerebellar granules in monozygotic twins

1954 ◽  
Vol 3 (2) ◽  
pp. 153-162 ◽  
Author(s):  
George A. Jervis
Keyword(s):  
Granular Layer ◽  
Genetic Factors ◽  
Cerebellar Atrophy ◽  
Monozygotic Twins ◽  
Cerebellar Granules

SummaryThe case is described of monozygotic twins similarly affected with a form of cerebellar atrophy characterized by primary lesions of the granular layer. The clinical and pathologic aspects of the disease are briefly discussed and the role of genetic factors in the determination of the condition emphasized.

Spinal cord infarction associated with primary antiphospholipid syndrome in a young child

1993 ◽  
Vol 79 (3) ◽  
pp. 446-450 ◽  
Author(s):  
Mitsuhiro Hasegawa ◽  
Junkoh Yamashita ◽  
Tetsumori Yamashima ◽  
Kiyonobu Ikeda ◽  
Yoshie Fujishima ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Spinal Cord Ischemia ◽  
Anticardiolipin Antibody ◽  
Acute Stage ◽  
Spinal Cord Infarction ◽  
Primary Antiphospholipid Syndrome ◽  
Content Type

✓ Antiphospholipid antibodies have been reported to occur in ischemic stroke patients, but there have been no previous reports linking these antibodies to spinal cord infarction. A case of spinal cord infarction associated with primary antiphospholipid syndrome in a 6-year-old boy is reported. Magnetic resonance imaging clearly demonstrated marked swelling of the thoracolumbar spinal cord with gadolinium-diethylenetriamine pentaacetic acid enhancement at an acute stage, followed later by cord atrophy. Serological study disclosed positive lupus anticoagulant and immunoglobulin G anticardiolipin antibody. It is suggested that the role of antiphospholipid antibodies as an etiological factor for spinal cord ischemia should be recognized among causes that might have been categorized as either spontaneous spinal cord infarction or myelitis.

ASSOCIATION OF C677T POLYMORPHISMS OF MTHFR GENE WITH RECURRENT PREGNANCY LOSS IN VIETNAMESE WOMAN

2019 ◽  
pp. 7-12
Author(s):  
Thanh Nha Uyen Le ◽  
Thi Minh Thi Ha ◽  
Viet Nhan Nguyen
Keyword(s):  
Pregnancy Loss ◽  
Genetic Factors ◽  
Recurrent Pregnancy Loss ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Control Group ◽  
Statistic Analysis ◽  
Vietnamese Woman ◽  
Vietnamese Women

Background: Recurrent pregnancy loss is a major concern in gynecology. Recently, many papers have showed the role of genetic factors in etiology of recurrent pregnancy loss. Several published studied revealed that C677T polymorphism is a high risk of recurrent pregnancy loss. However, this finding is still controversy. Therefore, this study is aimed at investigating the association of C677T polymorphisms of MTHFR gene with recurrent pregnancy loss in Vietnamese woman. Methods: Study subjects comprised 100 healthy women (control group) and 52 women with recurrent pregnancy loss. C677T polymorphisms were identified by PCR-technique. Results: The frequency of 677CC, 677CT, and 677TT genotypes in Vietnamese women with recurrent pregnancy loss is 65.4%, 30.8%, 3.8%, respectively; while the distribution of those genotypes in the control-group is 86%, 12%, và 2% (χ2 = 8.83; p = 0.012). Statistic analysis revealed that MTHFR C677T polymorphismsare associated with recurrent pregnancy loss (for CT vs. CC: OR= 3.37, 95%CI: 1.44 – 7.87, p = 0.0049; for (677CT + 677TT) vs. CC: OR= 3.25, 95%CI: 1.46 – 7.26, p = 0.004; for T vs. C: OR= 2.74, 95%CI:1.55 – 5.55, p = 0.005). Key words: Recurrent pregnancy loss, C677T polymorphisms, MTHFR gene

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