genetic factor
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2022 ◽  
Author(s):  
Muhammad Sudais

Abstract Sleep paralysis is a state of consciousness experienced while waking from sleep or falling asleep. It is characterized by an experience of being unable to move for several seconds or minutes. Sleep paralysis entails a period of paralysis upon waking or falling asleep and is often accompanied by terrifying hallucinations. Many stressful environmental factors which cause emotional stress also induce sleep paralysis. In addition to stressful environmental factors being associated with the condition, there appears to be a dominant genetic factor associated with the predisposition for developing sleep paralysis. The implications of these findings for stress, anxiety, and sleep are discussed. Almost three hundred people from various age groups of Karachi city were targeted as the respondents. A multifactor questionnaire was constructed to measure the effects of sleep paralysis – independent variable, and the human psychology – dependent variable. Regression analysis was performed and proposed two models using SPSS. The results of statistical tests were concluded in a way that how sleep paralysis effects a person’s life. The final results showed the effects of sleep paralysis on one’s psychology and personal life.


2022 ◽  
Author(s):  
Muhammad Sudais

Abstract Sleep paralysis is a state of consciousness experienced while waking from sleep or falling asleep. It is characterized by an experience of being unable to move for several seconds or minutes. Sleep paralysis entails a period of paralysis upon waking or falling asleep and is often accompanied by terrifying hallucinations. Many stressful environmental factors which cause emotional stress also induce sleep paralysis. In addition to stressful environmental factors being associated with the condition, there appears to be a dominant genetic factor associated with the predisposition for developing sleep paralysis. The implications of these findings for stress, anxiety, and sleep are discussed. Almost three hundred people from various age groups of Karachi city were targeted as the respondents. A multifactor questionnaire was constructed to measure the effects of sleep paralysis – independent variable, and the human psychology – dependent variable. Regression analysis was performed and proposed two models using SPSS. The results of statistical tests were concluded in a way that how sleep paralysis effects a person’s life. The final results showed the effects of sleep paralysis on one’s psychology and personal life.


2021 ◽  
Vol 14 (1) ◽  
pp. 34-48
Author(s):  
Abdullah Ahmad Tawakul ◽  
Amal Waleed Al-Doboke ◽  
Shahad Ali Altayyar ◽  
Seham Abdulhafith Alsulami ◽  
Ahlam Musallam Alfahmi ◽  
...  

There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain–Barré syndrome (GBS). This review aims to present information on the reports of GBS associated with coronavirus disease 2019 (COVID-19) infection. Our review is retrospective work examining articles published from the 1 April 2020 to the 8 May 2021 in the English language. We used the diagnostic criteria and classification published by the National Institute of Neurological Disorders and Stroke and Brighton Collaboration. GBS is usually a postinfectious syndrome, but GBS in the COVID-19 pandemic also takes on a para-infectious profile. In the reports, the genetic factor has a role in developing GBS in some patients. In conclusion, the association between COVID-19 and GBS is not very clear. Still, one mechanism is strongly associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between SARS-CoV-2 and human autoantigens.


2021 ◽  
Vol 935 (1) ◽  
pp. 012010
Author(s):  
E D Chirgin ◽  
V G Semenov ◽  
A S Mokretsova ◽  
D S Balitskaya ◽  
E I Ustinova ◽  
...  

Abstract The article presents the results of studies to establish the influence of the record productivity of mothers’ mares on milk yield and the duration of productive life of mares-daughters of the Lithuanian heavy draft breed. It was found that the high level of milk productivity of mothers during the period of highest lactation (up to 4000 kg of milk) enabled their daughters to become leaders already during the first lactation. With an increase in the record milk yields per lactation in mothers, the heritability coefficient in mother-daughter pairs decreased and turned into negative values. The daughters of mares with record milk yields of up to 8000 are the most dairy among their contemporaries. The research results indicate that intensive milk production of mares during the first lactation can cause a reduction in the terms of their economic use due to the large loads on the developing fragile animal organism. The highest rates of productive life, number of lactations and life-long milk yield were obtained from daughters whose mothers had record milk yields per lactation from 7000 kg to 8000 kg of milk.


Author(s):  
Kanyarat Khaeso ◽  
Patcharee Komwilaisak ◽  
Su-on Chainansamit ◽  
Nontaya Nakkam ◽  
Kunanya Suwannaying ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Minjie Sheng ◽  
Haiying Cai ◽  
Qin Yang ◽  
Jing Li ◽  
Jian Zhang ◽  
...  

Lymphoma is a serious type of cancer, especially for adolescents and elder adults, although this malignancy is quite rare compared with other types of cancer. The cause of this malignancy remains ambiguous. Genetic factor is deemed to be highly associated with the initiation and progression of lymphoma, and several genes have been related to this disease. Determining the pathogeny of lymphoma by identifying the related genes is important. In this study, we presented a random walk-based method to infer the novel lymphoma-associated genes. From the reported 1,458 lymphoma-associated genes and protein–protein interaction network, raw candidate genes were mined by using the random walk with restart algorithm. The determined raw genes were further filtered by using three screening tests (i.e., permutation, linkage, and enrichment tests). These tests could control false-positive genes and screen out essential candidate genes with strong linkages to validate the lymphoma-associated genes. A total of 108 inferred genes were obtained. Analytical results indicated that some inferred genes, such as RAC3, TEC, IRAK2/3/4, PRKCE, SMAD3, BLK, TXK, PRKCQ, were associated with the initiation and progression of lymphoma.


2021 ◽  
Author(s):  
Basista Rabina Sharma ◽  
Ravindra P. Veeranna

Research so far indicates that gut microbiome and diet interactions influence obesity, diabetes, host immunity, and brain function. The ability of athletes to perform to optimum for a more extended time, as well as the ability to resist, withstand, recover from, and have immunity to fatigue, injury depends on the genetic factor, age, sex, training history, psychological factors, mode, intensity and frequency of training and their interactions with the external dietary components. However, recent evidence indicates that the gut microbiome may also potentially influence the development of endurance in response to the type and composition of the external diet, including several food supplements. Thus, the gut microbiome has become another target in the athlete’s pursuit of optimal performance. This chapter discusses the effect of exercise on the gut microbiome, the interplay between dietary components and supplements on the gut microbiome, and its impact on endurance performance.


2021 ◽  
Vol 51 ◽  
pp. e19
Author(s):  
Danielle Dick ◽  
Sandra Sanchez-Roige ◽  
Richard Karlsson Linnér ◽  
Travis Mallard ◽  
Peter Barr ◽  
...  

2021 ◽  
Vol 51 ◽  
pp. e129
Author(s):  
Daniela Distel ◽  
Lea Zillich ◽  
Bernhard Maier ◽  
Katharina Wildenberg ◽  
Michael Deuschle ◽  
...  

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