Spinal cord infarction associated with primary antiphospholipid syndrome in a young child

1993 ◽  
Vol 79 (3) ◽  
pp. 446-450 ◽  
Author(s):  
Mitsuhiro Hasegawa ◽  
Junkoh Yamashita ◽  
Tetsumori Yamashima ◽  
Kiyonobu Ikeda ◽  
Yoshie Fujishima ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Spinal Cord Ischemia ◽  
Anticardiolipin Antibody ◽  
Acute Stage ◽  
Spinal Cord Infarction ◽  
Primary Antiphospholipid Syndrome ◽  
Content Type

✓ Antiphospholipid antibodies have been reported to occur in ischemic stroke patients, but there have been no previous reports linking these antibodies to spinal cord infarction. A case of spinal cord infarction associated with primary antiphospholipid syndrome in a 6-year-old boy is reported. Magnetic resonance imaging clearly demonstrated marked swelling of the thoracolumbar spinal cord with gadolinium-diethylenetriamine pentaacetic acid enhancement at an acute stage, followed later by cord atrophy. Serological study disclosed positive lupus anticoagulant and immunoglobulin G anticardiolipin antibody. It is suggested that the role of antiphospholipid antibodies as an etiological factor for spinal cord ischemia should be recognized among causes that might have been categorized as either spontaneous spinal cord infarction or myelitis.

Barbiturate protection in acute experimental spinal cord ischemia

1982 ◽  
Vol 56 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Edward H. Oldfield ◽  
Robert J. Plunkett ◽  
William A. Nylander ◽  
William F. Meacham
Keyword(s):  
Spinal Cord ◽  
Histological Study ◽  
Spinal Cord Ischemia ◽  
Spinal Cord Infarction ◽  
Pathophysiological Mechanism ◽  
Microscopic Appearance ◽  
Content Type ◽  
Cord Injury ◽  
Barbiturate Protection ◽  
Fine Print

✓ Ischemia is the pathophysiological mechanism in many types of spinal cord injury. In the present study, the infrarenal segment of the aorta was occluded for 25 minutes to produce spinal cord infarction in rabbits. Paraplegia occurred in 100% of control animals. Thiopental administered before aortic occlusion resulted in paraplegia in only 40% of animals so treated (p < 0.01). Histological study of the spinal cord demonstrated infarction of the gray matter in all paraplegic animals, whereas the microscopic appearance was normal in animals without neurological deficit. The protective influence of thiopental therapy in spinal cord ischemia was demonstrated.

Percutaneous flexible bipolar epidural neuroelectrode for spinal cord stimulation

1984 ◽  
Vol 60 (6) ◽  
pp. 1317-1319 ◽  
Author(s):  
Alfred G. Kaschner ◽  
Wilhelm Sandmann ◽  
Heinz Larkamp
Keyword(s):  
Spinal Cord ◽  
Evoked Potentials ◽  
Epidural Space ◽  
Somatosensory Evoked Potentials ◽  
Spinal Cord Stimulation ◽  
Spinal Cord Ischemia ◽  
Aortic Occlusion ◽  
Content Type ◽  
Fine Print

✓ This article describes a new flexible bipolar neuroelectrode which is inserted percutaneously into the epidural space for segmental spinal cord stimulation. This electrode was used in experiments with dogs and monkeys for recording cortical somatosensory evoked potentials in order to identify intraoperative spinal cord ischemia during periods of aortic occlusion.

Antibodies to phosphatidylserine/prothrombin (aPS/PT) enhanced the diagnostic performance in Chinese patients with antiphospholipid syndrome

2018 ◽  
Vol 56 (6) ◽  
pp. 939-946 ◽  
Author(s):  
Shulan Zhang ◽  
Ziyan Wu ◽  
Wen Zhang ◽  
Jiuliang Zhao ◽  
Gary L. Norman ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Arterial Thrombosis ◽  
Diagnostic Performance ◽  
Positive Likelihood Ratio ◽  
Chinese Patients ◽  
Healthy Controls ◽  
Patients At Risk

AbstractBackground:Increasing evidence has highlighted the role of non-criteria antiphospholipid antibodies (aPLs) as important supplements to the current criteria aPLs for the diagnosis of antiphospholipid syndrome (APS). In this retrospective study, we evaluated the clinical relevance of antibodies to phosphatidylserine/prothrombin (aPS/PT) in Chinese patients with APS.Methods:A total of 441 subjects were tested, including 101 patients with primary APS (PAPS), 140 patients with secondary APS (SAPS), 161 disease controls (DCs) and 39 healthy controls (HCs). Serum IgG/IgM aPS/PT was determined by ELISA.Results:The levels of IgG/IgM aPS/PT were significantly increased in patients with APS compared with DCs and HCs. IgG and IgM aPS/PT were present in 29.7% and 54.5% of PAPS, and 42.1% and 53.6% of SAPS, respectively. For diagnosis of APS, IgG aCL exhibited the highest positive likelihood ratio (LR+) of 21.60, followed by LA (13.84), IgG aβ2GP1 (9.19) and IgG aPS/PT (8.49). aPS/PT was detected in 13.3% of seronegative PAPS patients and 31.3% of seronegative SAPS patients. LA exhibited the highest OR of 3.64 in identifying patients with thrombosis, followed by IgG aCL (OR, 2.63), IgG aPS/PT (OR, 2.55) and IgG aβ2GP1 (OR, 2.33). LA and IgG aCL were correlated with both arterial and venous thrombosis, whereas IgG aPS/PT and IgG aβ2GP1 correlated with venous or arterial thrombosis, respectively.Conclusions:Our findings suggest that the inclusion of IgG/IgM aPS/PT may enhance the diagnostic performance for APS, especially in those in whom APS is highly suspected, but conventional aPLs are repeatedly negative. In addition, IgG aPS/PT may contribute to identify patients at risk of thrombosis.

Thienylphencyclidine protection for the spinal cord of adult rats against extension of lesions secondary to a photochemical injury

1993 ◽  
Vol 78 (4) ◽  
pp. 603-609 ◽  
Author(s):  
Philippe Pencalet ◽  
Freddy Ohanna ◽  
Philippe Poulat ◽  
Jean-Marc Kamenka ◽  
Alain Privat
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neurological Impairment ◽  
Treated Group ◽  
Untreated Group ◽  
Spinal Cord Infarction ◽  
Adult Rats ◽  
Content Type ◽  
Arterial Blood ◽  
Cord Injury

✓ The purpose of this study was to evaluate treatment with the N-methyl-D-aspartate antagonist thienylphencyclidine (TCP) after spinal cord injury for its behavioral, electrophysiological, morphological, and immunohistochemical effects. Five minutes after a photochemical lesion was produced in rats at the T-8 level, the animals received TCP (1 mg/kg, intravenously) or TCP vehicle (saline). The animals were evaluated on Day 18 for neurological recovery by testing motor and sensory functions. The TCP-treated group showed less neurological impairment than the untreated group (p < 0.05 for inclined-plane stability and withdrawal reflex to extension). Somatosensory evoked potential testing was performed on Days 21 to 23 and the wave amplitude between the onset and P1 in the TCP-treated group was higher than in the untreated group (p < 0.05). Mean arterial blood pressure was not significantly modified after TCP injection. Morphometric studies of the lesion area in cross section revealed a significantly reduced spinal cord infarction in the TCP-treated group (p < 0.05). Immunohistochemical evaluation of the spinal cord in lumbar area showed an increased level of serotonin immunoreactivity in the dorsal horn of animals treated by TCP. These results demonstrate the efficacy of TCP in reducing secondary lesions after spinal cord injury in rats.

Long-term use of hydroxychloroquine reduces antiphospholipid antibodies levels in patients with primary antiphospholipid syndrome

2016 ◽  
Vol 65 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Entela Nuri ◽  
Mara Taraborelli ◽  
Laura Andreoli ◽  
Marta Tonello ◽  
Maria Gerosa ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Primary Antiphospholipid Syndrome
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