The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease

Introduction: Behçet’s disease (BD) is a debilitating and chronic vasculitis which can affect multiple organs. Recurrent oral aphthosis is the most common clinical feature of BD. The remarkable pain associated with painful oral ulcers can exert a major impact on the patients’ quality of life. Relieving pain of these oral ulcers is an essential approach in the management of mucocutaneous lesions of BD. Non-thermal CO2 laser therapy (NTCLT) as a novel photobiomodulative approach has recently been used for significant and immediate pain reduction of some types of painful oral lesions such as recurrent aphthous stomatitis, pemphigus vulgaris, and so on. In this procedure by some considerations, the conventional CO2 laser is used as a non-surgical, non- thermal, photobiomodulative laser without any visible thermal adverse effects. In this article, we report our experiences about the analgesic effects of NTCLT on painful oral aphthous ulcers of BD. Case Presentation: We report four cases of BD, whose painful oral aphthous ulcers were irradiated with NTCLT. Immediately after NTCLT, the pain of the lesions was significantly relieved with no visible complications. Conclusion: The results of this study suggest that NTCLT could be proposed as a hopeful procedure for significant and instant pain relief of oral aphthous ulcers of BD without any visible thermal adverse effects.

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A case of intestinal Behcet’s disease under Adalimumab

Case Reports in Internal Medicine ◽

10.5430/crim.v4n3p62 ◽

2017 ◽

Vol 4 (3) ◽

pp. 62

Author(s):

David T. Dulaney ◽

Wassem Juakiem ◽

Katherine Cebe ◽

Angelo H. Paredes

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Immunosuppressive Agents ◽

African American Female ◽

Behcet's Disease ◽

Oral Ulcers ◽

Adalimumab Therapy ◽

Tnfα Inhibitors ◽

Tnfα Inhibitor

Behcet’s disease (BD) is a multisystem mucocutaneous inflammatory condition characterized by recurrent genital and oral ulcers, ocular inflammation, and can involve the gastrointestinal tract. Treatment involves the usage of immunosuppressive agents to control the disease with glucocorticoids utilized for treatment of flares. Tumor necrosis factor inhibitors are frequently used to control the disease as well. We present the case of a 40 years old African American female presenting with intestinal BD that was refractory to adalimumab therapy. In conjunction with glucocorticoids, the patient’s intestinal disease was controlled with infliximab therapy. Currently, there have been no studies comparing the efficacy of TNFα inhibitors on the treatment of BD. Future studies are needed to compare the efficacy of TNFα inhibitor agents in the treatment of intestinal manifestations of BD.

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Recurrent vulval ulceration: could it be Behçet's disease?

International Journal of STD & AIDS ◽

10.1258/ijsa.2012.012006 ◽

2012 ◽

Vol 23 (9) ◽

pp. 683-684

Author(s):

S Patel ◽

K Prime

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Disease ◽

Holistic Approach ◽

Nucleic Acid Amplification ◽

Behcet's Disease ◽

Oral Ulcers ◽

Caribbean Woman ◽

History Of

This report describes a young black Caribbean woman with a three-year history of recurrent genital ulceration initially diagnosed as genital herpes. This diagnosis had been made clinically by the general practitioner but never confirmed on culture or nucleic acid amplification testing; sequential treatment with aciclovir and famciclovir over a four-month period did not alleviate her genital symptoms. Presentation to our genitourinary (GU) medicine clinic identified painful aphthous genital and oral ulcers, erythema nodosum bilaterally and a history of eye irritation. A clinical diagnosis of Behçet's disease was made. Treatment with hydrocortisone mouth pellets and dermovate ointment was initiated in addition to dermatology and ophthalmology referral. This report reminds clinicians to consider alternative diagnoses in clinical practice when faced with patients who are resistant to treatment. It also highlights the importance of recognizing systemic disease and maintaining a holistic approach when treating patients.

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Bilateral Neuroretinitis and a Unilateral Superior Hemivein Occlusion with Frosted Branch Angiitis Pattern Presenting Simultaneously in Behçet's Disease

Case Reports in Ophthalmology ◽

10.1159/000444214 ◽

2016 ◽

Vol 7 (1) ◽

pp. 141-147 ◽

Cited By ~ 3

Author(s):

Roy Schwartz ◽

Sara Borok ◽

Michaella Goldstein ◽

Anat Kesler ◽

Keren Regev ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Erythema Nodosum ◽

Behçet's Disease ◽

Clinical Manifestations ◽

Unique Case ◽

Behcet's Disease ◽

Frosted Branch Angiitis ◽

Ocular Manifestations ◽

Aphthous Ulcers

Purpose: To report a unique case of Behçet's disease that presented with atypical ocular manifestations. Methods: Case report. Results: A 23-year-old homosexual male presented with bilateral anterior uveitis, vitritis, neuroretinitis and a unilateral superior hemivein occlusion with frosted branch angiitis pattern. These were accompanied by systemic findings of recurrent oral aphthous ulcers, erythema nodosum, and neurological and gastrointestinal involvement. A positive HLA-B51 examination supported the diagnosis of Behçet's disease. Conclusion: Neuroretinitis and frosted branch angiitis may be the clinical manifestations of Behçet's disease and may present simultaneously.

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Aortic thrombosis in a patient with a late diagnosis of Behcet's disease

Jornal Vascular Brasileiro ◽

10.1590/1677-5449.0065 ◽

2015 ◽

Vol 14 (2) ◽

pp. 193-196

Author(s):

Ana Bittencourt Detanico ◽

Marcelo Luiz Brandão ◽

Ly de Freitas Fernandes ◽

Carolina Parreira Ribeiro Camelo ◽

Juliano Ricardo Santana dos Santos

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Thromboangiitis Obliterans ◽

Unknown Etiology ◽

Behcet's Disease ◽

Oral Ulcers ◽

Arterial Involvement ◽

Genital Ulcers

Behcet's disease is form of systemic vasculitis of unknown etiology. One surprising feature is that arterial involvement is less common in this disease than venous forms, accounting for 1 to 7% of patients. In 7 to 30% of cases the vascular symptoms precede the clinical diagnosis of Behcet. We describe the case of a patient with Thromboangiitis Obliterans who was treated with lumbar sympathectomy and an aortobiiliac bypass. Around 1 year later he was diagnosed with Behcet's disease after presenting with oral ulcers, genital ulcers and scaling lesions on the hands.

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Ethiopathogenesis of Behçet's Disease

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0113 ◽

2018 ◽

pp. 324-328

Keyword(s):

Behçet’S Disease ◽

Genetic Factors ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Skin Lesions ◽

Th2 Cells ◽

Innate And Adaptive Immunity ◽

Behcet's Disease ◽

Oral Ulcers ◽

Th 1

Behçet’s disease (BD) is a chronic multisystem inflammatory disease characterized mainly by recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions, presenting with remission and exacerbations. The pathogenesis of BD has not been fully elucidated since it has a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. BD has been considered that both environmental and genetic factors contribute to its onset and development. Recent advances in molecular biology and genetics show us that particular genes encompass both innate and adaptive immunity, and confirm the importance of the predominant polarization towards helper T cell (Th)1 versus Th2 cells, and the involvement of Th17 cells in BD.

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