EFFECTS ON SEX HORMONE BINDING GLOBULIN OF DIFFERENT ORAL CONTRACEPTIVES CONTAINING NORETHISTERONE AND LYNESTRENOL

1980 ◽  
Vol 87 (5) ◽  
pp. 416-421 ◽  
Author(s):  
Viveca Odlind ◽  
E. Weiner ◽  
A. Victor ◽  
E. D. B. Johansson
Keyword(s):  
Oral Contraceptives ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Salivary and Plasma Free Testosterone and Androstenedione Levels in Women Using Oral Contraceptives Containing Desogestrel or Levonorgestrel

1988 ◽  
Vol 25 (4) ◽  
pp. 354-359 ◽  
Author(s):  
L M J W Swinkels ◽  
P M M Meulenberg ◽  
H A Ross ◽  
Th J Benraad
Keyword(s):  
Oral Contraceptives ◽  
Plasma Concentrations ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Hormone Binding ◽  
Direct Assay

The effect of oral contraceptives (OC) containing a combination of ethinyloestradiol (EE2) and either desogestrel (Dg/EE2) or levonorgestrel (Lg/EE2) on plasma concentrations of sex hormone binding globulin (SHBG), total testosterone (T), free T, total androstenedione (A), free A and on salivary T and A concentrations have been studied. SHBG concentrations were higher in the Dg/EE2 group than in the Lg/EE2 group. Total T, measured by RIA with prior extraction and chromatography, is also higher in the Dg/EE2 group. Per cent free T was lower in the Dg/EE2 group. Plasma free T and free A concentrations were the same in both groups. However, free T and free A were significantly lower in the OC-groups than in controls. In contrast, by direct assay, no difference in total T was observed between the OC-groups. Since the per cent free T was lower in the Dg/EE2 group, it would be concluded that free T in the Dg/EE2 group is lower than in the Lg/EE2 group. Salivary free T and free A concentrations did not differ between control and OC-groups. There was good correlation between salivary and free hormone concentrations within each group. We conclude that the concentrations of androgens in saliva do not necessarily directly reflect their free concentrations in plasma.

scholarly journals Sex Hormone Binding Globulin: Effect of Synthetic Steroids on the Assay and Effect of Oral Contraceptives

1981 ◽  
Vol 18 (4) ◽  
pp. 226-231 ◽  
Author(s):  
Susan M Bowles ◽  
Richard J Mills
Keyword(s):  
Oral Contraceptives ◽  
Side Effect ◽  
Binding Capacity ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Hormone Balance ◽  
Synthetic Steroids ◽  
Low Levels ◽  
Endogenous Sex Hormones

The effect that synthetic steroid components of different oral contraceptives have on the assay system for measurement of sex hormone binding globulin (SHBG)-binding capacity, has been examined. Interference with the assay was not demonstrable at therapeutic levels of the drugs. d-Norgestrel was the only steroid studied which bound to SHBG with an affinity comparable to the endogenous sex hormones; it also tended to decrease SHBG-binding capacity, whereas preparations containing low levels of norethisterone increased the binding capacity. We suggest that measurement of changes in SHBG-binding capacity in subjects taking oral contraceptives may prove useful in indicating changes in sex hormone balance, particularly in view of the well-recognised side-effect of these drugs.

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