NEUROCHEMISTRY OF THE SPINAL CORD IN BRITISH SADDLEBACK PIGLETS AFFECTED WITH CONGENITAL TREMOR, TYPE A-IV, A SECOND FORM OF HEREDITARY CEREBROSPINAL HYPOMYELINOGENESIS

Abstract BACKGROUND According to EANO-ESMO clinical practice guidelines, the MRI findings of LM are divided into 4 types, namely linear enhancement (type A), nodular enhancement (type B), linear combined with nodular enhancement (type C), and sign of hydrocephalus (type D). METHODS The MRI features of brain and spinal cord in patients diagnosed with NSCLC-LM in Guangdong Sanjiu Brain Hospital from 2010 until 2019 were investigated, and then were classified into 4 types. The imaging features were analyzed. RESULTS A total of 80 patients were enrolled in the study. The median age of the patients was 53.5 years old, and the median time from the initial diagnosis to the confirmed diagnosis of LM was 11.6 months. The results of enhanced MRI examination of the brain in 79 cases showed that the number of cases with enhancements of type A, B, C and D were 50 (63.3%), 0, 26 (32.9%) and 3 (3.8%), respectively, and that LM with metastases to the brain parenchyma was found in 42 cases (53.2%). The results of enhanced MRI examination of spinal cord in 59 cases showed that there were only enhancements of type A and C in 40 cases (67.8%) and 3 cases (5.0%), and no enhancement sign in the other 16 cases (27.2%). CONCLUSION MRI examination of brain and spinal cord will improve the detection rate of LM. The MRI features of NSCLC-LM in real world are mainly characterized by the linear enhancements of brain and spinal cord, followed by linear combined with nodular enhancement. The enhancements of type B and type D are rare in clinic. Almost half of the patients have LM and metastases to the brain parenchyma. Therefore, the differentiation of tumor metastases is needed to be paid attention to for the early diagnosis and the formulation of reasonable treatment plans.

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A transient spinal cord ischemia reveals a silent type A aortic dissection

Journal of Neurology & Stroke ◽

10.15406/jnsk.2021.11.00448 ◽

2021 ◽

Vol 11 (1) ◽

pp. 20-21

Author(s):

Rachelle Abi Nahed ◽

Wissam Rizk

Keyword(s):

Spinal Cord ◽

Aortic Dissection ◽

Spinal Cord Ischemia ◽

Type A ◽

Type A Aortic Dissection

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Botulinum toxin type A for the treatment of muscle contractures secondary to acute spinal cord injury in a young cat

Journal of Feline Medicine and Surgery Open Reports ◽

10.1177/2055116920922648 ◽

2020 ◽

Vol 6 (1) ◽

pp. 205511692092264

Author(s):

Robert I McGeachan ◽

Tobias Schwarz ◽

Danièlle A Gunn-Moore ◽

Katia Marioni-Henry

Keyword(s):

Spinal Cord ◽

Botulinum Toxin ◽

Botulinum Toxin Type A ◽

Clinical Signs ◽

Type A ◽

Botulinum Toxin Type ◽

Subacute Stroke ◽

Thoracic Limb ◽

Cord Injury ◽

The Right

Case summary A 4-month-old male entire domestic shorthair cat presented for sudden onset of right thoracic monoparesis following a fall; within 18 h, the clinical signs progressed to non-ambulatory right hemiplegia with absent sensation in the distal right thoracic limb and left hemiparesis. MRI revealed changes consistent with a C6–C7 acute non-compressive nucleus pulposus extrusion with suspected secondary C5–C7 spinal cord haemorrhage. Rehabilitation exercises were started immediately after the diagnosis of acute spinal cord trauma. Sensation in the right thoracic limb improved and, with the help of a splint applied to that limb, the cat was ambulatory on all four limbs. Unfortunately, clinical signs started to progress over the course of 10 days. The cat developed progressive discomfort on manipulation of the right elbow and carpus, and a hyperflexion of the right carpus. Radiographs revealed no skeletal abnormalities. Muscle contractures were suspected. Under general anaesthesia the triceps and flexor muscles of the carpus and digits were injected with a total of 100 U of botulinum toxin type A (BTX-A). No complications were associated with the procedure and 24 h after the injection the carpal hyperflexion resolved. Relevance and novel information The use of BTX-A to treat muscle contractures in human medicine is an established and increasingly used technique. For example, in subacute stroke patients with a non-functional arm, BTX-A forearm injection appears to prevent disabling finger stiffness, likely by minimising the development of contractures. Here, we demonstrate that intramuscular BTX-A is an effective treatment for acquired muscle contractures in a cat.

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