Determination of the mean transit time for the transport of aerosolized99mTc-DTPA across the pulmonary epithelial membrane. A plasma sample method

1988 ◽  
Vol 8 (2) ◽  
pp. 93-103 ◽  
Author(s):  
S. Groth ◽  
N. A. Lassen ◽  
N. Rossing
Keyword(s):  
Transit Time ◽  
Plasma Sample ◽  
Mean Transit Time ◽  
Plasma Sample Method ◽  
The Mean ◽  
Sample Method

scholarly journals Comparison of Gates’ Method and CKD-EPI Equation with Plasma Sample Method for Estimation of GFR

2019 ◽  
Vol 22 (1) ◽  
pp. 36-40
Author(s):  
Suraya Sarmin ◽  
Sadia Sultana ◽  
Madhuchhanda Hazra Mou ◽  
Naheed Khan ◽  
Pupree Mutsuddy ◽  
...  
Keyword(s):  
Gold Standard ◽  
Filtration Rate ◽  
Plasma Sample ◽  
Strong Positive Correlation ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Disease Epidemiology ◽  
Plasma Sample Method ◽  
The Mean ◽  
Sample Method

Objectives: Glomerular Filtration Rate (GFR) is an important parameter of kidney function. Many methods are used to measure GFR namely: inulin clearance, double plasma sample method (DPSM), Gates’ method, and equation based method. DPSM has become the gold standard in clinical research. Gates’ method is routinely practiced at National Institute of Nuclear Medicine and Allied Sciences. Chronic kidney disease epidemiology collaboration (CKD-EPI ) equation is encouraged as it is simple and reliable. The aim of the study was assesment of agreement between Gates’ method and CKD-EPI equation with plasma sample method for estimation of GFR. Patients and methods: This cross sectional observational study was carried out at NINMAS, during July 2017 to June 2018. A total of 70 subjects referred for 99mTC-DTPA renography along with GFR estimation, were included in this study. Result: The mean GFR value evaluated by DPSM, Gates’ and CKD-EPI  equation were, 81.86 ± 22.42, 86.13 ± 26.70 and 78.48 ± 23.87 mL/min/1.73 m2 respectively. A strong positive correlation (r = 0.922) was found between DPSM and Gates’ method and also between DPSM and CKD-EPI equation (r= 0.930). The Gates’ and CKD-EPI equation also showed strong positive correlation (r = 0.872). The mean difference between DPSM and Gates’, between DPSM and CKD-EPI equation,  between Gates’ and CKD-EPI equation were 4.26 ± 10.45, 3.38 ± 8.78  and  7.64 ± 13.09 mL/min/1.73 m2 respectively. Conclusion: Strong positive correlation and excellent agreement were observed between DPSM and Gates’ and also between DPSM and CKD-EPI equation. Strong correlation was also found in between Gates’ and CKD-EPI equation. So, DPSM, Gates’ method and CKD-EPI equation can reflect GFR almost equally and used interchangeably. Bangladesh J. Nuclear Med. 22(1): 36-40, Jan 2019  

scholarly journals Assessment of Agreement between Gates Method and Dual Plasma Sample Method for Measurement of Glomerular Filtration Rate

2018 ◽  
Vol 20 (1) ◽  
pp. 19
Author(s):  
Pupree Mutsuddy ◽  
Mohammad Anwar Ul Azim ◽  
Shamim MF Begum ◽  
Raihan Hussain ◽  
Sharmin Farhana ◽  
...  
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Plasma Sample ◽  
Mean Difference ◽  
Strong Positive Correlation ◽  
Plasma Sample Method ◽  
The Mean ◽  
Sample Method

<p><strong>Objectives:</strong> Glomerular filtration rate (GFR) is generally considered to be the best index of renal function in both healthy and diseased kidneys. Calculation of GFR plays a vital role in the management of patients having renal diseases. Clinicians can make their final decision regarding the potential need for kidney transplantation and also selection of a potential kidney donor. Many methods have been developed in order to obtain more accurate GFR values. The most popular radionuclide method is camera based Gates method using 99mTc DTPA (Diethylene triaminepentaacetic acid). This method can provide immediate calculation of individual kidney function as well as of global renal function. But several sources of errors may reduce the reliability of this method. Measurement of multiple blood samples offers almost real values of GFR, which have become the gold standard in clinical research. The aim of this research work was to study the agreement between Gates method and dual plasma sample method for measurement of GFR.</p><p><strong>Patients and methods:</strong> This cross sectional study was carried out in National Institute of Nuclear Medicine &amp; Allied Sciences (NINMAS), during July 2015 to June 2016. A total of 59 patients were included in this study. GFR was estimated by both the camera based Gates method and dual plasma sample method (DPSM).Statistical analyses were carried out by using the Statistical Package for Social Sciences version 20.0 for Windows (SPSS Inc., Chicago, Illinois, USA). The mean values were calculated for continuous variables. Categorical data were expressed in percentage and number. Pearson correlation and Bland &amp; Altman (B &amp; A) analyses were applied for assessing correlation and agreement between Gates method and DPSM. Degree of relation between the variables is expressed by r (Pearson’s correlation coefficient).</p><p><strong>Results:</strong> The mean GFR evaluated by Gates method was found 82.2 ± 27.4 mL/min/1.73m<sup>2</sup> and mean GFR by DPSM was found 82.8 ± 24.1 mL/min/1.73m<sup>2</sup>. A strong positive correlation (r = 0.833; p = 0.001) was found between the GFR values measured by Gates method and DPSM. With Bland and Altman analysis, it was observed that mean difference of GFR measured by Gates method and DPSM was – 0.6 ± 15.22 mL/min/1.73m<sup>2</sup>. The limit of agreement ranged from – 30.44 mL/min/1.73m<sup>2</sup> to 29.24 mL/min/1.73m<sup>2</sup>.</p><p><strong>Conclusion:</strong> There was strong positive correlation between Gates method and DPSM for measurement of GFR. Mean difference between the methods was small. The bias between the methods was considered not significant. The differences within mean ± 1.96 SD are not clinically important. Hence Gates method and DPSM can reflect GFR almost equally and can be used interchangeably.</p><p>Bangladesh J. Nuclear Med. 20(1): 19-23, January 2017</p>

scholarly journals Use of the mean transit time of an intravascular contrast agent as an exchange-insensitive index of myocardial perfusion

1999 ◽  
Vol 9 (3) ◽  
pp. 402-408 ◽  
Author(s):  
Massimo Lombardi ◽  
Richard A. Jones ◽  
J�rgen Westby ◽  
Geir Torheim ◽  
Timothy E. Southon ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Contrast Agent ◽  
Transit Time ◽  
Mean Transit Time ◽  
Intravascular Contrast Agent ◽  
The Mean

Lung water measurements with the mean transit time approach

1985 ◽  
Vol 59 (3) ◽  
pp. 673-683 ◽  
Author(s):  
R. M. Effros
Keyword(s):  
Transit Time ◽  
Mean Transit Time ◽  
Tissue Perfusion ◽  
Time Data ◽  
Lung Water ◽  
Thermal Signal ◽  
The Mean ◽  
Points Of View ◽  
Vascular Obstruction ◽  
Pulmonary Vascular Obstruction

The potential usefulness and limitations of the double-indicator mean transit time approach for measuring lung water are evaluated from both theoretical and empirical points of view. It is concluded that poor tissue perfusion is the most serious factor that can compromise the reliability of this approach. Replacement of the conventional water isotopes with a thermal signal enhances indicator delivery to ischemic areas but the diffusion of heat is not sufficiently rapid to permit measurements of water in macroscopic collections of fluid which remain unperfused. The frequency of pulmonary vascular obstruction in patients with pulmonary edema related to lung injury suggests that interpretation of transit time data will be complicated by uncertainties concerning perfusion. Thermal-dye measurements of lung water may prove more helpful in situations where pulmonary blood flow remains relatively uniform.

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