scholarly journals The booster injection of antigen during active sensitization of guinea-pig modifies the anti-anaphylactic activity of the PAF antagonist WEB 2086

1990 ◽  
Vol 100 (2) ◽  
pp. 217-222 ◽  
Author(s):  
S. Desquand ◽  
J. Lefort ◽  
C. Dumarey ◽  
B.B. Vargaftig
Keyword(s):  
Guinea Pig ◽  
Booster Injection ◽  
Web 2086

scholarly journals Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man

1988 ◽  
Vol 94 (1) ◽  
pp. 164-168 ◽  
Author(s):  
Timothy W. Evans ◽  
Gordon Dent ◽  
Duncan F. Rogers ◽  
Boonrut Aursudkij ◽  
K. Fan Chung ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Guinea Pig ◽  
Microvascular Leakage ◽  
Web 2086

[3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung

1989 ◽  
Vol 169 (2-3) ◽  
pp. 313-316 ◽  
Author(s):  
Gordon Dent ◽  
Dieter Ukena ◽  
Gerhard W. Sybrecht ◽  
Peter J. Barnes
Keyword(s):  
Guinea Pig ◽  
Human Lung ◽  
Platelet Activating Factor ◽  
Web 2086

scholarly journals Interference of WEB 2086 and BN 52021 with Paf-induced effects on guinea-pig trachea

1989 ◽  
Vol 97 (2) ◽  
pp. 469-474 ◽  
Author(s):  
Sandra Brunelleschi ◽  
Daniela Renzi ◽  
Fabrizio Ledda ◽  
Alberto Giotti ◽  
Roberto Fantozzi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Web 2086

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

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