ANALISIS BIBLIOMETRIC DARI SERTIFIKAT TANAH (BIBLIOMETRIC OF LAND CERTIFICATE)

This article is a bibliometric analysis of articles published in Scopus indexed journals that discuss land certificates. Knowing how studies related to land certificates are progressing is the aim of this research. Data was collected from the Scopus database by using the keyword term "land certificate". The researchers analyzed and visualized the database obtained in the VosViewer software. The highest number of citations occurred in 2016-2020 was 31 citations. The most publication trend occurred in 2019 with 40 articles. Articles from the collaboration of three authors include 12 articles from Deininger K., 8 from Ritz B. 8 and 3 from Zhang I. The most common title terms are “policy, demography” (2000) 20 items, “environmental protection” (2005) 55 items, “human, female, male” (2010) 23 items, “certification, land tenure, land use” (2015) 24 items. Abstract as many as 52 items 'human', 41 items 'humans', 23 items 'certificate', and 21 items 'land use'. Moreover, the country that published the most land certificate articles was the United States with 64 articles, followed by China with 29 articles and Germany with 21 articles. Citation analysis in the article the land certificate shows an increase as well as a decrease. The highest citation rate occurred in 2020, while the citation of land titling articles decreased in 2021.

Mermaid Allusions and Star Promotion in the Greek Video-Film Gorgona (1987)

This article examines the first Greek film to give a central role to the concept of the mermaid: Georges Skalenakis’ 1987 direct-to-video feature Gorgona (‘Mermaid’). Although actually concerning an all-human female, Gorgona attaches to her many traits of both the internationally common half-fish/half-woman creature (known in Greek as γοργόνα/gorgona) and the mermaid sister (also known as γοργόνα) in the legend of Alexander the Great. The article identifies the video-film’s allusions to these fishtailed figures and argues that the film produced an updated mermaid image that responded to other national and foreign audiovisual conceptions of the mermaid of the 1980s and enriched the star persona of its female lead, Eleni Filini, with a mythic quality and national symbolism.

Conclusion

Fat is much more than a physical imperfection, practical inconvenience, or health risk. Instead, it is a fascinating, mysterious, and misunderstood tissue that represents an ancient link between energy metabolism, reproductive biology, immunity, appetite, and even thermoregulation. It also forms the foundation of the curves which define the archetypal human female and male body shapes, which have since enabled the human body to transcend mere physicality and become social, economic, and political barometers. Laden with increasingly complex, nuanced, and even paradoxical meanings, mounting evidence indicates that the amount and distribution of fat not only provide our body with a distinctive shape, but are also a strong determinant of our health. Adipose tissue carries many negative connotations due to the numerous ailments associated with having too much of it, but it is not inherently bad. On the contrary, it has a legacy that clearly indicates it is essential for life.

Moon Triggers “Menstrual Clock”

The study presents that Human Basal Ganglia situated underneath the Human Brain is a plausible reflection of the Solar System wherein the nine celestial bodies are the cosmic counterparts of the nine Basal Nuclei Orders in many aspects such as their orbital location and their significations in astrology of their organization and functions. Moon, the cosmic counterpart of Hypothalamus, together with the other messengers, namely the pituitary gland and the ovary, plausibly regulate human female menstrual cycle. The releasing of hormones by Hypothalamus and its messengers in a rhythmic fashion appear to be the result of variation in the intensity of lunar magnetism. Human females plausibly have an internal ‘menstrual clock’ that helps them anticipate and adapt to the regular rhythm so that it is synchronized with the Moon’s revolutions.

Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells

Unlike autosomal tumor suppressors, which must be inactivated by a two-hit Knudson mechanism, X-linked tumor suppressors can be inactivated by a single hit due to X-chromosome inactivation (XCI). Here, we argue that targeted reactivation of the non-mutated allele from XCI offers a potential therapy for female breast cancers. Towards this goal, we developed a dual CRISPR interference and activation (CRISPRi/a) approach for simultaneously silencing and reactivating multiple X-linked genes using two orthogonal, nuclease-deficient CRISPR/Cas9 (dCas9) proteins. We verified the efficacy for use of Streptococcus pyogenes (Sp) dCas9-KRAB for silencing XIST and Staphylococcus aureus (Sa) dCas9-VPR for activating FOXP3 in various cell lines of human female breast cancers. We confirmed CRISPR reactivation of the non-mutated copy of FOXP3 from XCI in human breast cancer CRL2316 cells, which express a synonymous heterozygous mutation (p.L266L; c.798G>C) in the coding region of FOXP3. Further, simultaneous silencing of XIST from XCI led to enhanced and prolonged FOXP3 reactivation. We optimized CRISPRa by fusing SadCas9 to the demethylase TET1 and observed enhanced FOXP3 activation. Analysis of the conserved CpG-rich region of FOXP3 intron 1 confirmed that CRISPRi/a-mediated simultaneous FOXP3 activation and XIST silencing were accompanied by elevated H4 acetylation, including H4K5ac, H4K8ac, and H4K16ac, and lower DNA methylation and H3K9me3. This indicates that CRISPRi/a targeting to XIST and FOXP3 loci alters their transcription and their nearby epigenetic modifications. The simultaneous activation and repression of the X-linked, endogenous FOXP3 and XIST from XCI offers a useful research tool and a potential therapeutic for female breast cancers. This approach also provides new routes of targeted therapy for other X-chromosome-linked genetic disorders.

Thyroid, Adrenal, PRL Impairments and Ovarian Function

Endocrine axes (prolactin, thyroid and adrenal axes) directly and indirectly modulate and drive human female central functions, mainly behavior and reproduction. Though having distinct abilities, they greatly act both at peripheral as well as at neuroendocrine levels, so as to participate in the control of reproduction. Any event that changes these balanced activities produces specific peripheral signals that induce abnormal functions centrally, thus triggering menstrual disorders such as oligomenorrhea or amenorrhea. It is clear that the knowledge of the relationships that exist between the different endocrine axes becomes essential for the choice of therapeutical approach. This review aims to focus on the main aspects of the physiopathology of the endocrine diseases that might be at the basis of that interference with female reproductive capacity.