scholarly journals Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon

1996 ◽  
Vol 118 (1) ◽  
pp. 191-197 ◽  
Author(s):  
Reynold A. Panettieri ◽  
Roy G. Goldie ◽  
Paul J. Rigby ◽  
Andrew J. Eszterhas ◽  
Douglas W.P. Hay
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Endothelin 1 ◽  
Human Airway ◽  
Smooth Muscle Proliferation ◽  
Eta Receptor

Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation

1999 ◽  
Vol 277 (6) ◽  
pp. L1109-L1117 ◽  
Author(s):  
Simon Johnson ◽  
Alan Knox
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Airway Smooth Muscle ◽  
Fetal Bovine Serum ◽  
Platelet Derived Growth Factor ◽  
Airway Smooth Muscle Cells ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
Smooth Muscle Proliferation ◽  
Fetal Bovine

Airway smooth muscle proliferation is important in asthma and is dependent on pro- and antimitogenic factors and cell-matrix interactions. Here we show an antiproliferative effect of protease inhibitors on human airway smooth muscle due to inhibition of autocrine-derived matrix metalloproteinase (MMP)-2. Proliferation in response to fetal bovine serum, thrombin, and platelet-derived growth factor was inhibited by the broad-spectrum protease inhibitor Complete and the MMP inhibitors EDTA and Ro-31-9790 but not by cysteine or serine protease inhibitors. Conditioned medium from airway smooth muscle cells contained 72-kDa gelatinase that was secreted by growth-arrested cells and increased by fetal bovine serum but not by thrombin or platelet-derived growth factor. Immunostaining of cultured human airway smooth muscle cells and normal lung biopsies confirmed this gelatinase to be MMP-2. Our results suggest a novel role for MMP-2 as an important autocrine factor required for airway smooth muscle proliferation. Inhibition of MMPs could provide a target for the prevention of smooth muscle hyperplasia and airway remodeling in asthma.

Contraction of human airway smooth muscle by endothelin-1 and IRL 1620: effect of bosentan

1997 ◽  
Vol 324 (2-3) ◽  
pp. 219-222 ◽  
Author(s):  
Tsuneyuki Takahashi ◽  
Peter J Barnes ◽  
Ivana Kawikova ◽  
Magdi H Yacoub ◽  
Timothy D Warner ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Endothelin 1 ◽  
Human Airway

scholarly journals Heme Oxygenase Inhibits Human Airway Smooth Muscle Proliferation via a Bilirubin-dependent Modulation of ERK1/2 Phosphorylation

2003 ◽  
Vol 278 (29) ◽  
pp. 27160-27168 ◽  
Author(s):  
Camille Taillé ◽  
Abdelhamid Almolki ◽  
Moussa Benhamed ◽  
Christine Zedda ◽  
Jérôme Mégret ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Heme Oxygenase ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
Smooth Muscle Proliferation

KCa3.1 Ca2+Activated K+Channels Regulate Human Airway Smooth Muscle Proliferation

2007 ◽  
Vol 37 (5) ◽  
pp. 525-531 ◽  
Author(s):  
Malcolm C. Shepherd ◽  
S. Mark Duffy ◽  
Trudi Harris ◽  
Glenn Cruse ◽  
Michael Schuliga ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
K Channels ◽  
Human Airway ◽  
Smooth Muscle Proliferation
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