Syncope after whole blood donation: factors associated with increased donor injury

Introduction: According to German legislation, reports of suspected serious adverse reactions (AR) associated with the donation of blood and its components are continuously being evaluated by the Paul-Ehrlich-Institut. This survey aimed at providing a more complete picture of the AR associated with the donation of blood and blood components. Materials and Methods: Eligible donors had the opportunity to anonymously report all AR occurring during or after their last donation by completing an online questionnaire. Reported AR were classified according to the Standard for Surveillance of Complications Related to Blood Donation. Donors’ self-assessment of AR seriousness was compared with the official severity classification as laid down by German legislation. Besides a descriptive statistical analysis, a multiple logistic analysis was performed to identify risk factors for AR. Results: A total of 8,138 data records were evaluated. Slightly more males (57.9%) participated in the survey and, except for donors aged ≥60 years, all age groups were equally represented. The majority of participants were whole blood donors (85.4%), repeat donors (97.2%), and stayed under observation in the blood establishment (BE) for more than 5 min (63.1%) after donation. Most participants did not report any reaction (72.5%), whereas 2,237 reported at least one AR (27.5%), 475 of whom underwent apheresis and 1,762 donated whole blood. Most AR occurred after leaving the BE (64.4%). Only a minority of participants required medical treatment (5.1%) or assessed the experienced AR as serious (3.9%). The most frequently reported donor AR were haematoma and other local reactions (57.6%). Vasovagal reactions without and with loss of consciousness were developed in 17 and 2% of the participants, respectively, whilst 7.6% experienced citrate reactions. New AR (i.e., allergic reactions and symptoms associated with iron deficiency) were reported as well. The occurrence of AR was linked to risk factors (i.e., female gender, young age, first-time donation, and thrombocytapheresis). Discussion: This survey yielded a more comprehensive AR spectrum, revealed a prolonged time to symptom onset, and identified risk factors for AR. This novel information could be implemented in an amended informed consent addressing common and rare AR.

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Ultrasound-enabled topical anesthesia for pain reduction of phlebotomy for whole blood donation

Transfusion ◽

10.1111/j.1537-2995.2008.01939.x ◽

2009 ◽

Vol 49 (1) ◽

pp. 146-153 ◽

Cited By ~ 4

Author(s):

Christopher P. Stowell ◽

My-Quyen Trieu ◽

Han Chuang ◽

Nathaniel Katz ◽

Carole Quarrington

Keyword(s):

Whole Blood ◽

Blood Donation ◽

Pain Reduction ◽

Topical Anesthesia

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Adverse Reactions to Whole Blood Donation and Plasmapheresis

CRC Critical Reviews in Clinical Laboratory Sciences ◽

10.3109/10408368209107032 ◽

1982 ◽

Vol 17 (1) ◽

pp. 51-75 ◽

Cited By ~ 6

Author(s):

Alfred J. Grindon

Keyword(s):

Whole Blood ◽

Adverse Reactions ◽

Blood Donation

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Generation of reticulated platelets in responseto whole blood donation or plateletpheresis

Transfusion ◽

10.1046/j.1537-2995.2001.41101234.x ◽

2001 ◽

Vol 41 (10) ◽

pp. 1234-1240 ◽

Cited By ~ 12

Author(s):

Maria I.C. Gyongyossy-Issa ◽

Jorge Miranda ◽

Dana V. Devine

Keyword(s):

Whole Blood ◽

Blood Donation ◽

Reticulated Platelets

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The Informed Consent Process in Whole Blood Donation

Archives of Pathology & Laboratory Medicine ◽

10.5858/2008-132-947-ticpiw ◽

2008 ◽

Vol 132 (6) ◽

pp. 947-951 ◽

Cited By ~ 1

Author(s):

Lindsay A. Alaishuski ◽

Rodney D. Grim ◽

Ronald E. Domen

Keyword(s):

West Nile Virus ◽

Informed Consent ◽

Whole Blood ◽

Blood Donors ◽

Blood Donation ◽

Informed Consent Process ◽

Positive Test ◽

Consent Process ◽

West Nile ◽

Eligibility Requirements

Abstract Context.—Informed consent in transfusion medicine has been an area lacking of significant research and it is unknown if donors fully comprehend the risks associated with whole blood donation. Objective.—To assess the adequacy of the informed consent process in whole blood donation. Design.—A brief questionnaire was constructed and distributed to whole blood donors visiting various fixed and mobile donor sites of the Central Pennsylvania Blood Bank. Questions consisted of demographic information; donor opinions of information content, length, and comprehension; and a short quiz pertaining to donor risks and eligibility. Results.—Analysis of 849 surveys demonstrated that donors comprehended a mean of 73.5% of the various donor eligibility and risks that were surveyed. Female and younger donors scored statistically higher on comprehension questions compared with male and older counterparts. Donors were most aware of (1) donor eligibility requirements related to acquired immunodeficiency syndrome comprehension, (2) the risk of dizziness postdonation, and (3) having lived in a certain country (93.7%–95.6% comprehension, respectively). Donors were least aware of (1) the risk of a possible referral to a physician for outstanding medical conditions or positive test results, (2) the risk of a positive test result, and (3) West Nile virus testing information (22.4%–49.3% comprehension, respectively). Conclusions.—Whole blood donors believed that they were giving informed consent, but a significant percentage of donors were unaware of several of the risks associated with blood donation, including participation in West Nile virus research testing. Our data suggest that donors do not fully comprehend the risks of whole blood donation and that repetition of information to the donor, and in multiple formats, strengthens the level of comprehension and thus the informed consent process.

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Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali

BMC Infectious Diseases ◽

10.1186/s12879-019-4699-3 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Aude Jary ◽

Sidi Dienta ◽

Valentin Leducq ◽

Quentin Le Hingrat ◽

Mahamadou Cisse ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Marital Status ◽

Blood Donation ◽

Education Level ◽

Male Gender ◽

Hcv Infection ◽

Hbv Infection ◽

Factors Associated ◽

Hcv Prevalence

Abstract Background HIV, HBV and HCV remain a global public health concern especially in Africa. Prevalence of these infections is changing and identification of risk factors associated with each infection in Mali is needed to improve medical care. Methods We conducted a cross-sectional study of all individuals donating blood (n = 8207) in 2018 to the blood bank at university hospital in Bamako, Mali, to assess prevalence and risks factors associated with HIV, HBV, HCV and syphilis infections. Results HIV-seroprevalence was 2.16% and significantly increased with age, being married and decreasing education level. In multivariate analysis, after adjustements with age, marital status and geographical setting, only education level was associated with HIV-infection (OR, 1.54 [95% CI, 1.15–2.07], p = 0.016). HBsAg prevalence was 14.78% and significantly increased with to be male gender. In multivariate analysis, adjusting for age, marital status and type of blood donation, education level (OR, 1.17 [95%CI, 1.05–1.31], p = 0.02) and male gender (OR, 1.37 [95%CI, 1.14–1.65], p = 0.005) were associated with HBV-infection. HCV-prevalence was 2.32% and significantly increased with living outside Bamako. In multivariate analysis, adjusting for gender, age and education level, living outside Bamako was associated with HCV-infection (OR, 1.83 [95% CI, 1.41–2.35], p < 0.001). Syphilis seroprevalence was very low (0.04%) with only 3 individuals infected. Contrary to a prior study, blood donation type was not, after adjustments, an independent risk factor for each infection. Conclusions Overall, HIV and HBV infection was higher in individuals with a lower level of education, HBV infection was higher in men, and HCV infection was higher in people living outside of Bamako. Compared to studies performed in 1999, 2002 and 2007 in the same population, we found that HIV and HCV prevalence have decreased in the last two decades whereas HBV prevalence has remained stable. Our finding will help guide infection prevention and treatment programs in Mali.

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