Adverse Reactions to Whole Blood Donation and Plasmapheresis

Introduction: According to German legislation, reports of suspected serious adverse reactions (AR) associated with the donation of blood and its components are continuously being evaluated by the Paul-Ehrlich-Institut. This survey aimed at providing a more complete picture of the AR associated with the donation of blood and blood components. Materials and Methods: Eligible donors had the opportunity to anonymously report all AR occurring during or after their last donation by completing an online questionnaire. Reported AR were classified according to the Standard for Surveillance of Complications Related to Blood Donation. Donors’ self-assessment of AR seriousness was compared with the official severity classification as laid down by German legislation. Besides a descriptive statistical analysis, a multiple logistic analysis was performed to identify risk factors for AR. Results: A total of 8,138 data records were evaluated. Slightly more males (57.9%) participated in the survey and, except for donors aged ≥60 years, all age groups were equally represented. The majority of participants were whole blood donors (85.4%), repeat donors (97.2%), and stayed under observation in the blood establishment (BE) for more than 5 min (63.1%) after donation. Most participants did not report any reaction (72.5%), whereas 2,237 reported at least one AR (27.5%), 475 of whom underwent apheresis and 1,762 donated whole blood. Most AR occurred after leaving the BE (64.4%). Only a minority of participants required medical treatment (5.1%) or assessed the experienced AR as serious (3.9%). The most frequently reported donor AR were haematoma and other local reactions (57.6%). Vasovagal reactions without and with loss of consciousness were developed in 17 and 2% of the participants, respectively, whilst 7.6% experienced citrate reactions. New AR (i.e., allergic reactions and symptoms associated with iron deficiency) were reported as well. The occurrence of AR was linked to risk factors (i.e., female gender, young age, first-time donation, and thrombocytapheresis). Discussion: This survey yielded a more comprehensive AR spectrum, revealed a prolonged time to symptom onset, and identified risk factors for AR. This novel information could be implemented in an amended informed consent addressing common and rare AR.

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Adverse reactions to whole blood donation, basic human needs and nursing diagnoses: a reflection

Revista da Escola de Enfermagem da USP ◽

10.1590/s1980-220x2017005003284 ◽

2018 ◽

Vol 51 (0) ◽

Author(s):

Gabriela Feitosa Esplendori

Keyword(s):

Whole Blood ◽

Blood Donors ◽

Adverse Reactions ◽

Pain Perception ◽

Blood Donation ◽

Human Needs ◽

Physical Integrity ◽

Vascular Regulation ◽

Basic Human Needs ◽

Nursing Diagnoses

ABSTRACT A theoretical-Reflective study with the objective to reflect on human needs regarding the imbalance of whole blood donors considering adverse reactions to the donation, and the existing nursing diagnoses that best meet the imbalance needs. The following needs were pointed out according to the signs and symptoms of adverse reactions and based on the Theory of Basic Human Needs: skin and tissue integrity, emotional security, pain perception, body mechanics, oxygenation, physical integrity, physical comfort, elimination, neurological, electrolytic and vascular regulation. By observing NANDA International’s Definitions and Classifications, adaptations to the existing nursing diagnoses and suggestions for new headings have been proposed. We conclude that some of the needs are interrelated, such as vascular regulation, oxygenation and physical integrity. Thus, more contextualized nursing diagnoses related to the needs of whole blood donors are needed, given the specific nature of the situation generating imbalances such as: ineffective systemic vascular regulation characterized by self-reported dizziness, cutaneous pallor and arterial hypotension related to vasovagal reaction.

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Post-donation telephonic interview: A tool for active follow-up of voluntary whole blood donors for analysis of frequency and predisposing factors of adverse reactions

Indian Journal of Medical Sciences ◽

10.25259/ijms_499_2020 ◽

2021 ◽

Vol 0 ◽

pp. 1-7

Author(s):

Anisha Navkudkar ◽

Priti Desai ◽

Sunil Rajadhakshaya

Keyword(s):

Blood Supply ◽

Whole Blood ◽

Blood Donors ◽

Adverse Reactions ◽

Blood Donation ◽

Positive Impact ◽

Tertiary Care ◽

Statistical Tool ◽

Donor Safety

Objectives: Blood donation experience by most donors is satisfactory; however, a few may encounter adverse reactions. Healthy, altruistic, voluntary blood donors ensure adequate blood supply despite the potential risk of adverse reactions. Post-donation follow-up is crucial to get information about these adverse reactions. This study aimed to evaluate the frequency and type of adverse donor reactions and their correlation with contributory factors if any among the blood donors in a tertiary care oncology center. Material and Methods: It was a prospective observational study of 1000 consecutive voluntary whole blood donors who consented to participate in the study. Donors were followed up telephonically on two instances (first after 24 h of donation and second after 2 weeks of donation) and were asked a self-structured donor questionnaire to collect information regarding the adverse donor reactions if any. An appropriate statistical tool was used for analysis (IBM, SPSS software). Results: Of the 1000 voluntary whole blood donors, 92.6% (926/1000) responded to telephonic calls on both occasions. Of these 926, 8.5% (79/926) donors experienced adverse reactions. All these donors experienced immediate reactions, that is, within 24 h of donation while none reported fresh adverse reactions beyond 24 h–2 weeks. Of the 79 donors, 60% (49/79) experienced vasovagal reactions (VVR) and 40% (32/79) experienced hematoma including two donors who experienced both. A total of 86% (68/79) of reactions occurred in outdoor blood donation camps while 14% (11/79) occurred in-house (indoor). First time donors, female donors, and donors with weight on the lower side were more prone to immediate VVR (P < 0.05). Of the 49 VVR, 76% (37/49) were mild, 18% (9/49) were moderate, and 6% (3/49) were severe. Most of the hematomas, that is, 90% (29/32) occurred at outdoor blood donation camps while 10% (3/32) occurred indoor. Most hematomas (53%) took more than 7 days to recover. Conclusion: Post-donation interview proves to be an efficient tool to acquire information about adverse donor reactions. This will help in improving donor safety and satisfaction and will have a positive impact on the national blood supply by improving the donor return rate. Blood transfusion services (BTSs) staff must be trained to promptly identify the donor reactions onsite and manage them to enhance the donation experience of voluntary donors. Post-donation follow-up will aid in getting the donation experience and BTS can develop strategies to enhance it. This will also help in donor hemovigilance in the future for the betterment of donor safety.

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Adverse Reactions to Allogeneic Whole Blood Donation by 16- and 17-Year-Olds

JAMA ◽

10.1001/jama.299.19.2279 ◽

2008 ◽

Vol 299 (19) ◽

pp. 2279 ◽

Cited By ~ 116

Author(s):

Anne F. Eder

Keyword(s):

Whole Blood ◽

Adverse Reactions ◽

Blood Donation

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Feline blood donation adverse reactions: classification and description of acute and delayed reactions in a donor population

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x211020295 ◽

2021 ◽

pp. 1098612X2110202

Author(s):

Tiago AM Abreu ◽

Andreia ST Oliveira ◽

Rui RF Ferreira ◽

Sandrina MV Correia ◽

Mafalda SSQ Morais ◽

...

Keyword(s):

Blood Donors ◽

Adverse Reactions ◽

Blood Donation ◽

Animal Blood ◽

Veterinary Practitioner ◽

Donor Programme ◽

Donor Population ◽

Delayed Reactions ◽

Low Incidence ◽

High Level

Objectives This article aims to analyse the safety of feline blood donation by describing the frequency and nature of any adverse reactions and their causes, as well as propose measures to decrease the incidence of adverse reactions. Methods In this prospective study, any blood donor adverse reactions detected by the clinical staff during and immediately after donation were recorded. The owners of the cats were also surveyed by a veterinary practitioner or veterinary nurse 5 days after donation, using a predefined questionnaire to assess for any clinical or behavioural changes. Data were collected between January 2019 and March 2020 from blood donors enrolled in an animal blood bank programme. Results Of 3690 blood donations from 1792 feline donors assessed, post-donation reactions were reported in 1.14% (n = 42): 0.22% (n = 8) were acute reactions, which included weakness, pallor, tachypnoea and open-mouth breathing; and 0.92% (n = 34) were delayed post-donation reactions, with 0.16% involving cutaneous (haematomas and skin rashes, n = 6), 0.68% involving behavioural (n = 25) and 0.08% involving digestive (emesis and inappetence, n = 3) signs. Conclusions and relevance The low incidence of post-donation reactions in this study is encouraging, suggesting that a well-established protocol and competent staff can help to ensure a high level of safety in a feline donor programme and, in turn, increase the confidence of cat owners.

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