Long-term quality of life after pregnancy-related deep vein thrombosis and the influence of socioeconomic factors and comorbidity

Current guidelines recommend to prolong anticoagulant treatment in patients with cancer with venous thromboembolism (VTE); only few studies evaluated other parameters than cancer itself for selecting patients at higher risk of recurrent VTE. Long-term management of VTE is thus challenged by several controversies mainly for patients compliance. We here report results of a long-term follow-up in patients with deep vein thrombosis under anticoagulant treatment with low-molecular-weight heparin (LMWH) for residual vein thrombosis (RVT) detected at compression ultrasonography (CUS), 6 months after standard anticoagulant treatment. Patients with RVT were deemed at high risk of recurrences and included in the current observational study. They continued LMWH (reduced at 75% standard dose) for further additional 2 years after enrolment or until death. Patients were followed up every 3 months or earlier, if needed. Among ancillary study end points, there was the assessment of patients’ quality of life during daily treatment with subcutaneous injections. Quality of life was determined by the EORTC-C30 questionnaire, administered by a skilled psychologist at enrolment and every 6 months follow-up visits. Overall, 128 patients were evaluated during follow-up. Mean global EORTC-C30 score at enrollment and at 6, 12 and 24 months follow-up were 52.1, 51.4, 50.8 and 50.1, respectively. There were no statistically significant differences between scores at enrolment and at the last available follow-up (P = .1). Long-term treatment with LMWH resulted, effective and safe, it was globally well tolerated and exempt of negative impact on quality of life of the enrolled patients. Reported results support long-term anticoagulant treatment with LMWH in cancer patients at risk of recurrent VTE.

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Long-term outcomes after deep vein thrombosis: Postphlebitic syndrome and quality of life

Journal of General Internal Medicine ◽

10.1046/j.1525-1497.2000.06419.x ◽

2000 ◽

Vol 15 (6) ◽

pp. 425-429 ◽

Cited By ~ 82

Author(s):

Susan R. Kahn ◽

Susan Solymoss ◽

Donna L. Lamping ◽

Lucien Abenhaim

Keyword(s):

Quality Of Life ◽

Deep Vein Thrombosis ◽

Long Term Outcomes ◽

Vein Thrombosis ◽

Postphlebitic Syndrome ◽

Deep Vein

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Late consequences of venous thromboembolism: Measuring quality of life after deep vein thrombosis and pulmonary embolism

Thrombosis Research ◽

10.1016/j.thromres.2017.07.025 ◽

2018 ◽

Vol 164 ◽

pp. 170-176 ◽

Cited By ~ 13

Author(s):

Waleed Ghanima ◽

Hilde Skuterud Wik ◽

Mazdak Tavoly ◽

Tone Enden ◽

Lars-Petter Jelsness-Jørgensen

Keyword(s):

Quality Of Life ◽

Pulmonary Embolism ◽

Deep Vein Thrombosis ◽

Venous Thromboembolism ◽

Vein Thrombosis ◽

Deep Vein

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A Health-Related Quality of Life Measure in Patients with Deep Vein Thrombosis: A Validation Study

Drug Information Journal ◽

10.1177/009286159903300421 ◽

1999 ◽

Vol 33 (4) ◽

pp. 1173-1187 ◽

Cited By ~ 23

Author(s):

Susan D. Mathias ◽

Lee Ann Prebil ◽

Caryn G. Putterman ◽

Joseph J. Chmiel ◽

Richard C. Throm ◽

...

Keyword(s):

Quality Of Life ◽

Deep Vein Thrombosis ◽

Validation Study ◽

Health Related Quality ◽

Life Measure ◽

Vein Thrombosis ◽

Related Quality ◽

Health Related ◽

Deep Vein

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Health-related quality of life after deep vein thrombosis

SpringerPlus ◽

10.1186/s40064-016-2949-z ◽

2016 ◽

Vol 5 (1) ◽

Cited By ~ 15

Author(s):

Kristin Kornelia Utne ◽

Mazdak Tavoly ◽

Hilde Skuterud Wik ◽

Lars Petter Jelsness-Jørgensen ◽

René Holst ◽

...

Keyword(s):

Quality Of Life ◽

Deep Vein Thrombosis ◽

Health Related Quality ◽

Vein Thrombosis ◽

Related Quality ◽

Health Related ◽

Deep Vein

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Deep vein thrombosis and our treatment applications: 12-year results

Journal of Clinical Images and Medical Case Reports ◽

10.52768/2766-7820/1253 ◽

2021 ◽

Vol 2 (4) ◽

Author(s):

Borulu F ◽

◽

Erkut B ◽

Keyword(s):

Quality Of Life ◽

Molecular Weight ◽

Deep Vein Thrombosis ◽

Low Molecular Weight Heparin ◽

Mechanical Thrombectomy ◽

Heparin Therapy ◽

Low Molecular Weight ◽

Vein Thrombosis ◽

Deep Vein

Introduction: Deep vein thrombosis is an important health problem that is frequently encountered in the general population and especially in surgical clinics and has a negative impact on quality of life. In this study, treatment options and results of patients with deep vein thrombosis who have been hospitalized for 12 years in Atatürk University and Erzurum Regional Hospital were examined and discussed. Methods: In our clinic, 412 cases of deep vein thrombosis (211 female, 201 male) were hospitalized between 2009 and 2021. The mean age of the patients was 49 ± 19 years. While medical treatment with heparin was given to all 412 patients; thrombolytic therapy, surgical embolectomy (vascular and pulmoner), and pharmaco-mechanical thrombectomy were applied to some of these patients. Results: Deep vein thrombosis was more common in the lower extremity (n=322, 78.2%). All patients had at least one of the complaints of pain, swelling and redness. All cases were diagnosed by color Doppler ultrasonography. Medically, standard and low molecular weight heparin therapy was given to all patients after hospitalization. Thrombolytic therapy was applied to 66 (16,1%) of the cases, pulmonary embolectomy to 8 (1,9%), surgical thrombectomy to 10 (2,4%) and pharmacomechanical thrombectomy to 44 (10,7%) patients. In addition to these 120 patients (29.1%), a vena cava filter was placed for prophylactic purposes. Conclusions: In patients diagnosed with deep vein thrombosis and hospitalized, the diagnosis should be supported by Doppler ultrasound in addition to clinical diagnosis after an etiology investigation. Early diagnosis, rapid and effective treatment methods are important for the subsequent quality of life of patients. In addition to low molecular weight heparins being the first choice agents, standard heparin administration still needs to be applied in some clinical pictures. In addition, we believe that pharmacomechanical thrombectomy can be applied in appropriate acute cases. Keywords: Deep vein thrombosis; anticoagulant treatment; heparin therapy; low-molecular-weight heparin; mechanical thrombectomy.

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Treatment of Acute Iliofemoral Deep Vein Thrombosis; Does Catheter Directed Thrombolytic Therapy Change Outcomes?

Cardiology Open Access ◽

10.33140/coa.04.03.01 ◽

2019 ◽

Vol 4 (3) ◽

Keyword(s):

Quality Of Life ◽

Deep Vein Thrombosis ◽

Iliac Vein ◽

P Value ◽

Vein Thrombosis ◽

Catheter Directed Thrombolysis ◽

Group A ◽

Deep Vein

Background: Iliofemoral deep vein thrombosis (DVT) is associated with severe post-thrombotic morbidity when treated with anticoagulation alone. Catheter- directed thrombolysis (CDT) allows early removal of thrombus and reduces valvular reflux and Post-thrombotic Syndrome (PTS). Patients and methods: This prospective randomized multi-center controlled two- arm blind study was conducted in 6 centers on 252 patients with iliofemoral DVT. Patients were randomly allocated by using simple random allocation cards method into two groups; Group (A): CDT followed by oral anticoagulation (N=126 (50%)), Group (B): Standard DVT therapy (N=126 (50%)). Follow-up was for 24 months. Results: Patients of group (A) significantly complained less pain at 10 & 30 days (P-Value: 0.02 & 0.04 respectively). Also there was significant decrease in leg circumference in group (A) at 10 & 30 days (P-Value: 0.001 & 0.03 respectively). Patency of iliac vein segment was significantly higher in group (A) during the 24 months follow up (P-Value <0.001 (HS)). Patients in group (A) developed less PTS at six months, at one year and at two years (P-Value: 0.024, 0.017 and 0.035 respectively). Better Quality of life was observed in group (A) (P-Value: 0.003). Conclusion: Addition of catheter-directed thrombolysis in the treatment of acute iliofemoral DVT; was safe and tolerated by most of the patients with better effect to reduce leg pain & circumference. It was considered a protecting weapon to prevent post-thrombotic syndrome and so improve quality of life and was related to achievement of higher iliac vein patency and less reflux.

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