Defense mechanism of heme oxygenase-1 against cytotoxic and receptor activator of nuclear factor-?B ligand inducing effects of hydrogen peroxide in human periodontal ligament cells

2007 ◽  
Vol 42 (4) ◽  
pp. 331-339 ◽  
Author(s):  
S.-H. Pi ◽  
S.-C. Kim ◽  
H.-T. Kim ◽  
H.-J. Lee ◽  
S.-K. Lee ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Heme Oxygenase ◽  
Periodontal Ligament ◽  
Defense Mechanism ◽  
Periodontal Ligament Cells ◽  
Heme Oxygenase 1 ◽  
Nuclear Factor ◽  
Factor B ◽  
Human Periodontal Ligament Cells ◽  
Receptor Activator

scholarly journals Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yoshitaka Hosokawa ◽  
Ikuko Hosokawa ◽  
Kazumi Ozaki
Keyword(s):  
Tumor Necrosis Factor ◽  
Periodontal Ligament ◽  
Tumor Necrosis ◽  
Periodontal Ligament Cells ◽  
Heme Oxygenase 1 ◽  
Nuclear Factor ◽  
Human Periodontal Ligament Cells ◽  
Chemokine Ligand ◽  
Anti Inflammatory ◽  
Necrosis Factor

Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent. In this study, we aimed to examine the anti-inflammatory effects of nobiletin on tumor necrosis factor- (TNF-) stimulated human periodontal ligament cells (HPDLCs). Our results demonstrated that nobiletin treatment could decrease the expressions of inflammatory cytokines (C-X-C motif chemokine ligand (CXCL)10, C-C motif chemokine ligand (CCL)2, and interleukin- (IL-) 8), matrix metalloproteinases (MMPs) (MMP1 and MMP3), and prostaglandin-endoperoxide synthase 2 (PTGS2) in TNF-stimulated HPDLCs. Moreover, we revealed that nobiletin could inhibit the activation of nuclear factor- (NF-) κB and protein kinase B (AKT1) pathways in TNF-stimulated HPDLCs. Furthermore, nobiletin treatment enhanced nuclear factor, erythroid 2 like 2 (NFE2L2) and heme oxygenase 1 (HMOX1) expressions in TNF-stimulated HPDLCs. In conclusion, these findings suggest that nobiletin can inhibit inflammatory responses in TNF-stimulated HPDLCs by inhibiting NF-κB and AKT1 activations and upregulating the NFE2L2 and HMOX1 expression.

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