Anti-inflammatory effects of lindenenyl acetate via heme oxygenase-1 and AMPK in human periodontal ligament cells

2011 ◽  
Vol 670 (1) ◽  
pp. 295-303 ◽  
Author(s):  
Gil-Saeng Jeong ◽  
Dong-Sung Lee ◽  
Bin Li ◽  
Jong-Jin Kim ◽  
Eun-Cheol Kim ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Periodontal Ligament ◽  
Periodontal Ligament Cells ◽  
Heme Oxygenase 1 ◽  
Human Periodontal Ligament Cells ◽  
Anti Inflammatory

scholarly journals Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yoshitaka Hosokawa ◽  
Ikuko Hosokawa ◽  
Kazumi Ozaki
Keyword(s):  
Tumor Necrosis Factor ◽  
Periodontal Ligament ◽  
Tumor Necrosis ◽  
Periodontal Ligament Cells ◽  
Heme Oxygenase 1 ◽  
Nuclear Factor ◽  
Human Periodontal Ligament Cells ◽  
Chemokine Ligand ◽  
Anti Inflammatory ◽  
Necrosis Factor

Nobiletin, a biologically active substance in the skin of citrus fruits, has been reported to be an effective anti-inflammatory, anticancer, and antimicrobial agent. In this study, we aimed to examine the anti-inflammatory effects of nobiletin on tumor necrosis factor- (TNF-) stimulated human periodontal ligament cells (HPDLCs). Our results demonstrated that nobiletin treatment could decrease the expressions of inflammatory cytokines (C-X-C motif chemokine ligand (CXCL)10, C-C motif chemokine ligand (CCL)2, and interleukin- (IL-) 8), matrix metalloproteinases (MMPs) (MMP1 and MMP3), and prostaglandin-endoperoxide synthase 2 (PTGS2) in TNF-stimulated HPDLCs. Moreover, we revealed that nobiletin could inhibit the activation of nuclear factor- (NF-) κB and protein kinase B (AKT1) pathways in TNF-stimulated HPDLCs. Furthermore, nobiletin treatment enhanced nuclear factor, erythroid 2 like 2 (NFE2L2) and heme oxygenase 1 (HMOX1) expressions in TNF-stimulated HPDLCs. In conclusion, these findings suggest that nobiletin can inhibit inflammatory responses in TNF-stimulated HPDLCs by inhibiting NF-κB and AKT1 activations and upregulating the NFE2L2 and HMOX1 expression.

scholarly journals Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huxiao Li ◽  
Jianrong Xu ◽  
Xiaotian Li ◽  
Yi Hu ◽  
Yue Liao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Periodontal Ligament ◽  
Target Genes ◽  
Chinese Herb ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells ◽  
Estrogen Receptor Signaling ◽  
Receptor Signaling Pathway ◽  
Anti Inflammatory ◽  
Molecule Docking

AbstractPsoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.

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