scholarly journals Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule- and Dynein-Dependent Manner

Traffic ◽  
2008 ◽  
Vol 9 (8) ◽  
pp. 1268-1282 ◽  
Author(s):  
Steeve Boulant ◽  
Mark W. Douglas ◽  
Laura Moody ◽  
Agata Budkowska ◽  
Paul Targett-Adams ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Droplet ◽  
Core Protein ◽  
Dependent Manner ◽  
Virus Core

scholarly journals Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein

2010 ◽  
Vol 67 (18) ◽  
pp. 3151-3161 ◽  
Author(s):  
Marion Depla ◽  
Rustem Uzbekov ◽  
Christophe Hourioux ◽  
Emmanuelle Blanchard ◽  
Amélie Le Gouge ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Lipid Droplet ◽  
Core Protein ◽  
Virus Core

scholarly journals Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1

2000 ◽  
Vol 74 (4) ◽  
pp. 1736-1741 ◽  
Author(s):  
Hiroshi Aoki ◽  
Junpei Hayashi ◽  
Mitsuhiko Moriyama ◽  
Yasuyuki Arakawa ◽  
Okio Hino
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Growth Regulation ◽  
Core Protein ◽  
Dependent Manner ◽  
Kinase Activation ◽  
Virus Core ◽  
Hcv Core Protein

ABSTRACT Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver dysfunction in humans and is epidemiologically closely associated with the development of human hepatocellular carcinoma. Among HCV components, core protein has been reported to be implicated in cell growth regulation both in vitro and in vivo, although mechanisms explaining those effects are still unclear. In the present study, we identified that members of the 14-3-3 protein family associate with HCV core protein. 14-3-3 protein bound to HCV core protein in a phosphoserine-dependent manner. Introduction of HCV core protein caused a substantial increase in Raf-1 kinase activity in HepG2 cells and in a yeast genetic assay. Furthermore, the HCV core–14-3-3 interaction was essential for Raf-1 kinase activation by HCV core protein. These results suggest that HCV core protein may represent a novel type of Raf-1 kinase-activating protein through its interaction with 14-3-3 protein and may contribute to hepatocyte growth regulation.

scholarly journals Hepatitis C Virus Core Protein Decreases Lipid Droplet Turnover

2011 ◽  
Vol 286 (49) ◽  
pp. 42615-42625 ◽  
Author(s):  
Charles Harris ◽  
Eva Herker ◽  
Robert V. Farese ◽  
Melanie Ott
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Droplet ◽  
Core Protein ◽  
Virus Core

scholarly journals The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly

2007 ◽  
Vol 282 (51) ◽  
pp. 37158-37169 ◽  
Author(s):  
Anna Shavinskaya ◽  
Steeve Boulant ◽  
Francois Penin ◽  
John McLauchlan ◽  
Ralf Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Lipid Droplet ◽  
Core Protein ◽  
Virus Assembly ◽  
Binding Domain ◽  
Major Determinant ◽  
Virus Core

Proteomic Profiling of Lipid Droplet Proteins in Hepatoma Cell Lines Expressing Hepatitis C Virus Core Protein

2006 ◽  
Vol 139 (5) ◽  
pp. 921-930 ◽  
Author(s):  
Shigeko Sato ◽  
Masayoshi Fukasawa ◽  
Yoshio Yamakawa ◽  
Tohru Natsume ◽  
Tetsuro Suzuki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cell Lines ◽  
Lipid Droplet ◽  
Core Protein ◽  
Hepatoma Cell ◽  
Proteomic Profiling ◽  
Hepatoma Cell Lines ◽  
Virus Core

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

2004 ◽  
Author(s):  
Rin Yamaguchi ◽  
Seiya Momosaki ◽  
Guang Gao ◽  
Chu Hsia ◽  
Masamichi Kojiro ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Core ◽  
Hepatocellular Carcinomas

Genetic control of the murine humoral response to distinct epitopes of hepatitis C virus core protein

1995 ◽  
Vol 2 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Z. Chen ◽  
I. Berkower ◽  
R. Y.-H. Wang ◽  
W.-M. Ching ◽  
H. J. Alter ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Control ◽  
Core Protein ◽  
Humoral Response ◽  
Virus Core
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