ACID-BASE AND ELECTROLYTE BALANCE IN NEWBORN INFANTS OF DIABETIC MOTHERS

With the increased incidence of diabetic women reaching the child-bearing ages and their fertility being improved as a result of the use of insulin, there will be an increase in the number of newborn infants of diabetic mothers. Except for better control of diabetes in the mother there is no known method to reduce the infant mortality rate, which remains very high, approximately 30%. Likewise there is at present no completely adequate explanation for this poor prognosis. The present study of the blood electrolyte balance was undertaken to elucidate certain points in the physiology of the newborn infant of a diabetic mother. The 11 infants studied had extremely variable plasma chloride and total base levels and a high proportion of these had an uncompensated acidosis with a lowered blood pH when compared to the normal newborn infant. The high plasma CO2 tension indicates that ventilatory control of this factor was lacking, whether the fault be central or pulmonary. Furthermore, there appears to be a direct correlation between the degree of acidosis and the severity of the abnormal clinical picture present. The exact cause of this acidosis is not at present clear.

Download Full-text

Leptin Concentrations Are Elevated in Newborn Infants of Diabetic Mothers

Hormone Research in Paediatrics ◽

10.1159/000049993 ◽

2001 ◽

Vol 55 (4) ◽

pp. 185-190 ◽

Cited By ~ 24

Author(s):

Päivi Tapanainen ◽

Erja Leinonen ◽

Aimo Ruokonen ◽

Mikael Knip

Keyword(s):

Newborn Infants ◽

Infants Of Diabetic Mothers ◽

Diabetic Mothers

Download Full-text

Water and Electrolyte Economy in Newborn Infants of Diabetic Mothers

Acta Paediatrica ◽

10.1111/j.1651-2227.1960.tb07713.x ◽

1960 ◽

Vol 49 (2) ◽

pp. 121-128 ◽

Cited By ~ 5

Author(s):

CHARLES D. COOK ◽

DONOUGH O'BRIEN ◽

JOHN D. L. HANSEN ◽

MARC BEEM ◽

CLEMENT A. SMITH

Keyword(s):

Newborn Infants ◽

Infants Of Diabetic Mothers ◽

Diabetic Mothers

Download Full-text

Body Composition of Newborn Infants of Diabetic Mothers, Mogens Osler, Copenhagen F, Denmark, Osler, 1961, 79 pp

PEDIATRICS ◽

10.1542/peds.29.5.728 ◽

1962 ◽

Vol 29 (5) ◽

pp. 728-728

Author(s):

Marvin Cornblath

Keyword(s):

Body Composition ◽

Urinary Excretion ◽

Newborn Infants ◽

Body Water ◽

Review Of The Literature ◽

Infants Of Diabetic Mothers ◽

Proper Length ◽

Diabetic Mothers

Dr. Osler, in his monograph, merely reiterates and summarizes work he has done in studying the height, weight, urinary excretion, and compartmental body water in babies of diabetic mothers. In the monograph, he presents the data in a fashion that makes it impossible to analyze and has added nothing new except that the diabetic baby is the proper length for its weight. In addition, he has made a sketchy, uncritical review of the literature pertaining to these babies and presents the data, again, in a summary fashion.

Download Full-text

CHAPTER V: Pathogenetic aspects of some of the characteristic features in newborn infants of diabetic mothers

Acta Paediatrica ◽

10.1111/j.1651-2227.1965.tb15580.x ◽

1965 ◽

Vol 54 (s158) ◽

pp. 71-75

Keyword(s):

Newborn Infants ◽

Infants Of Diabetic Mothers ◽

Characteristic Features ◽

Diabetic Mothers

Download Full-text

Relative Rates of Fetal Hemoglobin and Adult Hemoglobin Synthesis in Cord Blood of Infants of Insulin-Dependent Diabetic Mothers

PEDIATRICS ◽

10.1542/peds.75.6.1143 ◽

1985 ◽

Vol 75 (6) ◽

pp. 1143-1147 ◽

Cited By ~ 2

Author(s):

Harry Bard ◽

Janie Prosmanne

Keyword(s):

Newborn Infants ◽

Methyl Cellulose ◽

Fetal Hemoglobin ◽

Acid Mixture ◽

Hemoglobin Synthesis ◽

Infants Of Diabetic Mothers ◽

Insulin Dependent ◽

Adult Hemoglobin ◽

Insulin Dependent Diabetic ◽

Diabetic Mothers

Erythrocytosis, extramedullary erythropoiesis, and increased levels of plasma erythropoietin have been observed in newborn infants of diabetic mothers. Because there is evidence that there is a relationship between increased fetal hemoglobin production and acute erythropoietic expansion, it was considered important to study the proportion of fetal hemoglobin and adult hemoglobin synthesis in newborn infants of insulin-dependent diabetic mothers. Samples from nine newborn infants of diabetic mothers as well as nine control infants, ranging from 36 to 38 weeks of gestation, were incubated in an amino acid mixture containing [14C]leucine. The adult hemoglobin and fetal hemoglobin were then separated by column chromatography on DEAE [O-(diethylaminoethyl)] Sephadex. To confirm that the fetal hemoglobin obtained after Sephadex chromatography was not contaminated with other hemoglobins, several of the DEAE separations from each group were reconstituted and subjected to polypeptide chain elution using carboxyl-methyl cellulose chromatography. The data demonstrated that the newborn infants of diabetic mothers are synthesizing significantly more fetal hemoglobin than is expected for their period of development (82.2 ± 3.6 v 72.8 ± 4.2; P < .005). It is suggested that the in utero environment of the fetus of the diabetic mother causes an increase in fetal hemoglobin synthesis.

Download Full-text

ALPHA1-FETOPROTEIN AND CARBONIC ANHYDRASE B AND C CONCENTRATION IN CORD BLOOD FROM NEWBORN INFANTS OF DIABETIC MOTHERS

Acta Endocrinologica ◽

10.1530/acta.0.075s081 ◽

1974 ◽

Vol 77 (3_Suppl) ◽

pp. S81-S86 ◽

Cited By ~ 4

Author(s):

B. Nørgaard-Pedersen ◽

J. G. Klebe

Keyword(s):

Carbonic Anhydrase ◽

Cord Blood ◽

Gestational Age ◽

Newborn Infants ◽

Infants Of Diabetic Mothers ◽

Carbonic Anhydrase B ◽

Erythrocyte Carbonic Anhydrase ◽

Diabetic Mothers

ABSTRACT Erythrocyte carbonic anhydrase (CA) concentration B and C and the α1-fetoprotein (AFP) concentration was determined in cord blood from 45 newborn infants of diabetic mothers (IDM). The concentration of these quantities has separately been compared with the corresponding concentration in cord blood from normal newborn infants with the same gestational age. No difference was found except for AFP, where a significantly (P < 0.05) higher concentration was found in some infants of insulin treated diabetic mothers.

Download Full-text