Chronic granulocytic leukaemia in a dog with associated bacterial endocarditis, thrombocytopenia and preretinal and retinal haemorrhages

SummaryA l33Xe washout method has been used for measuring changes of blood flow in the proximal femur of a patient with the blastic crisis of chronic granulocytic leukaemia. In the hyperplastic phase the blood flow was highly increased and over three times greater than in the hypoplastic phase of the disease and over thirteen times greater than the value in normal bone. The bone circulation and especially the first component of the two-exponential bone washout curves appeared to reflect cell proliferation and neoplastic activity of the whole bone marrow. The method may provide clinically important information in the follow-up of selected haematological diseases.

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Purpuric palmar macule in a child with fever of unknown origin. Janeway lesion associated with subacute bacterial endocarditis (SBE)

Archives of Dermatology ◽

10.1001/archderm.128.5.682 ◽

1992 ◽

Vol 128 (5) ◽

pp. 682-683 ◽

Cited By ~ 2

Author(s):

E. E. Sahn

Keyword(s):

Fever Of Unknown Origin ◽

Unknown Origin ◽

Bacterial Endocarditis ◽

Subacute Bacterial Endocarditis

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Skin Manifestations in Subacute Bacterial Endocarditis

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.42.398 ◽

1980 ◽

Vol 42 (3) ◽

pp. 398-402

Author(s):

Yoshiko HITAKA ◽

Tsuguo HAMAGUCHI ◽

Tokuji KONISHI

Keyword(s):

Bacterial Endocarditis ◽

Subacute Bacterial Endocarditis ◽

Skin Manifestations

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HAEMOPOIETIC RECOVERY FROM Ph1 POSITIVE CHRONIC GRANULOCYTIC LEUKAEMIA

British Journal of Haematology ◽

10.1111/j.1365-2141.1987.tb04160.x ◽

1987 ◽

Vol 65 (4) ◽

pp. 500-501 ◽

Cited By ~ 3

Author(s):

F. Calvo ◽

H. De Castro ◽

R. Berger ◽

S. Collado ◽

L. Douay ◽

...

Keyword(s):

Chronic Granulocytic Leukaemia

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CHRONIC GRANULOCYTIC LEUKAEMIA IN ACCELERATED STAGE TREATED WITH LOW DOSE CYTOSINE ARABINOSIDE

British Journal of Haematology ◽

10.1111/j.1365-2141.1985.tb02868.x ◽

1985 ◽

Vol 61 (3) ◽

pp. 588-589 ◽

Cited By ~ 3

Author(s):

A. Waage ◽

J. Hammerstrøm ◽

J. Lamvik

Keyword(s):

Cytosine Arabinoside ◽

Low Dose ◽

Chronic Granulocytic Leukaemia

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Medicolegal Causation Investigation of Bacterial Endocarditis Associated with an Oral Surgery Practice Using the INFERENCE Approach

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18147530 ◽

2021 ◽

Vol 18 (14) ◽

pp. 7530

Author(s):

Putri Dianita Ika Meilia ◽

Maurice P. Zeegers ◽

Herkutanto ◽

Michael D. Freeman

Keyword(s):

Oral Surgery ◽

Invasive Procedure ◽

Bacterial Endocarditis ◽

Infection Prevention And Control ◽

Healthcare Associated Infection ◽

Department Of Health ◽

The Individual ◽

Healthcare Associated ◽

And Control ◽

Causation Analysis

Investigating causation is a primary goal in forensic/legal medicine, aiming to establish the connection between an unlawful/negligent act and an adverse outcome. In malpractice litigation involving a healthcare-associated infection due to a failure of infection prevention and control practices, the medicolegal causal analysis needs to quantify the individual causal probabilities to meet the evidentiary requirements of the court. In this paper, we present the investigation of the most probable cause of bacterial endocarditis in a patient who underwent an invasive procedure at a dental/oral surgical practice where an outbreak of bacterial endocarditis had already been identified by the state Department of Health. We assessed the probability that the patient’s endocarditis was part of the outbreak versus that it was an unrelated sporadic infection using the INFERENCE (Integration of Forensic Epidemiology and the Rigorous Evaluation of Causation Elements) approach to medicolegal causation analysis. This paper describes the step-by-step application of the INFERENCE approach to demonstrate its utility in quantifying the probability of causation. The use of INFERENCE provides the court with an evidence-based, transparent, and reliable guide to determine liability, causation, and damages.

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