The Blood?Brain Barrier: Methods for the Study of Peptide Transport Mechanisms. Introduction to Part II

1994 ◽  
Vol 739 (1 Models of Neu) ◽  
pp. 87-88
Author(s):  
WILLIAM A. BANKS
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Transport Mechanisms ◽  
Barrier Methods ◽  
Blood Brain

P4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells

2006 ◽  
Vol 2 ◽  
pp. S533-S534
Author(s):  
Kaoru Yamada ◽  
Chiori Yabuki ◽  
Masanori Tachikawa ◽  
Sumio Ohtsuki ◽  
Dudley K. Strickland ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Amyloid Β ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Amyloid Β Peptide ◽  
Blood Brain

scholarly journals Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

2017 ◽  
Vol 117 ◽  
pp. 182-194 ◽  
Author(s):  
Kerstin Römermann ◽  
Maren Fedrowitz ◽  
Philip Hampel ◽  
Edith Kaczmarek ◽  
Kathrin Töllner ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Therapeutic Potential ◽  
Brain Barrier ◽  
Mammalian Brain ◽  
Transport Mechanisms ◽  
Blood Brain ◽  
Multiple Blood

Peptide transport systems for opiates across the blood-brain barrier

1990 ◽  
Vol 259 (1) ◽  
pp. E1-E10 ◽  
Author(s):  
W. A. Banks ◽  
A. J. Kastin
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Transport Systems ◽  
Aluminum Stress ◽  
Melanocyte Stimulating Hormone ◽  
Blood Brain ◽  
Opiate Peptides ◽  
The Central Nervous System ◽  
Ethanol Addiction

Opiate peptides administered on one side of the blood-brain barrier can exert powerful effects on processes occurring on the other side. There is evidence for direct passage of opiate peptides and their analogues across this barrier. Beta-Endorphin can enter the cerebrospinal fluid after systemic administration, but its entry into brain tissue has been more difficult to demonstrate, even though analogues enter at a modest rate. Enkephalins enter and exit the central nervous system as intact molecules by a combination of saturable and nonsaturable mechanisms. A family of transport systems may exist with varying affinities for the opiate enkephalins, antiopiates like tyrosine melanocyte-stimulating hormone inhibitory factor 1 (Tyr-MIF-1), and related peptides. The major system transporting these peptides, termed Peptide transport system 1, can be influenced by several factors with entry and exit rates affected by aging, drugs, amino acids, monoamines, aluminum, stress, and ethanol addiction and withdrawal. The homeostatic role of the blood-brain barrier thus extends to the regulation of the bidirectional transport of informational peptides such as the opiates.

Stereospecific transport of Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1

1990 ◽  
Vol 25 (4) ◽  
pp. 589-592 ◽  
Author(s):  
William A. Banks ◽  
Abba J. Kastin ◽  
Edward A. Michals ◽  
Carlos M. Barrera
Keyword(s):  
Blood Brain Barrier ◽  
Transport System ◽  
Brain Barrier ◽  
Peptide Transport ◽  
Blood Brain ◽  
System 1
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