Expression of Osteopontin in a Macrophage Cell Line and in Transgenic Mice with Pulmonary Fibrosis Resulting from the Lung Expression of a Tumor Necrosis Factor-? Transgene

1995 ◽  
Vol 760 (1 Osteopontin) ◽  
pp. 334-341 ◽  
Author(s):  
YOSHITAKA MIYAZAKI ◽  
TAKAYOSHI TASHIRO ◽  
YASUNORI HIGUCHI ◽  
MIHOKO SETOGUCHI ◽  
SHUNSUKE YAMAMOTO ◽  
...  
Toxicology ◽  
2000 ◽  
Vol 143 (3) ◽  
pp. 235-247 ◽  
Author(s):  
Richard T Sawyer ◽  
Lori A Kittle ◽  
Hironobu Hamada ◽  
Lee S Newman ◽  
Priscilla A Campbell

Planta Medica ◽  
2002 ◽  
Vol 68 (11) ◽  
pp. 1036-1039 ◽  
Author(s):  
Jen-Hwey Chiu ◽  
Ing-Shiow Lay ◽  
Ming-Yuan Su ◽  
Hsiu-Li Chiu ◽  
Ai-Chin Chiu ◽  
...  

2017 ◽  
Vol 12 (1) ◽  
pp. 35 ◽  
Author(s):  
Dian Ratih Laksmitawati ◽  
Anisa Widyastuti ◽  
Nadia Karami ◽  
Ervi Afifah ◽  
Dwi Davidson Rihibiha ◽  
...  

<p class="Abstract">In this study, the anti-inflammatory potential of <em>Anredera </em>cordifolia and <em>Piper </em>crocatum extracts on lipopolysaccharide-induced murine macrophage cell line (RAW 264.7) was observed. Cell viability assay was performed with MTS assay. Parameters measured to determine the anti-inflammatory activity were interleukin-1β (IL-1β), tumor necrosis factor (TNF)-α, nitric oxide (NO) and IL-6. Both <em>A. </em>cordifolia and<em> P. </em>crocatum at concentration of 50 µg/mL in cell line resulted significant decrease in TNF-α level (250.3 and 242.5 pg/mL respectively). <em>A. </em>cordifolia showed significant decrease in IL-1β level at 50 µg/mL and IL-6 level at 10 µg/mL, whilst <em>P. </em>crocatum  showed significant decrease IL-1β level in three concentrations with lowest level at 50 µg/mL.<em> A. </em>cordifolia showed lowest decrease in NO level at 50 µg/mL but not comparable with normal cells, whilst <em>P. </em>crocatum showed significant decrease in NO level at 50 µg/mL. This research revealed that <em>A. </em>cordifolia and<em> P. </em>crocatum possess the anti-inflammatory potential indicated by the inhibitory activity of the inflammatory mediators including, TNF-α, IL-1β, IL-6, and NO.</p>


1993 ◽  
Vol 54 (4) ◽  
pp. 281-285 ◽  
Author(s):  
Gianna Scannell ◽  
Kenneth Waxman ◽  
Gary J. Kaml ◽  
Gene Ioli ◽  
Tetsuya Gatanaga ◽  
...  

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