Functional Tissue Engineering

2002 ◽  
Vol 961 (1) ◽  
pp. 193-195 ◽  
Author(s):  
Farshid Guilak
Keyword(s):  
Tissue Engineering ◽  
Functional Tissue Engineering ◽  
Functional Tissue

A Paradigm for Functional Tissue Engineering

2000 ◽  
Author(s):  
David L. Butler
Keyword(s):  
Tissue Engineering ◽  
Tendon Repair ◽  
National Committee ◽  
New Paradigm ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Tissue Engineer ◽  
Surgical Implants ◽  
The Us

Abstract Clinicians, biologists, and engineers face difficult challenges in engineering effective, cell-based composites for repair of orthopaedic and cardiovascular tissues. Whether repairing articular cartilage, bone, or blood vessel, the demands placed on the surgical implants can threaten the long-term success of the procedure. In 1998, the US National Committee on Biomechanics addressed this problem by suggesting a new paradigm for tissue engineering called “functional tissue engineering” or FTE. FTE seeks to address several important questions. What are the biomechanical demands placed upon the normal tissue and hence the tissue engineered implant after surgery? What parameters should a tissue engineer design into the implant before surgery? And what biomechanical parameters should the tissue engineer track to determine if the resulting repair is successful? To illustrate the principles, this presentation will discuss tendon repair as a model system for functional tissue engineering.

Functional Tissue Engineering Parameters toward Designing Repair and Replacement Strategies

2004 ◽  
Vol 427 ◽  
pp. S190-S199 ◽  
Author(s):  
David L Butler ◽  
Jason T Shearn ◽  
Natalia Juncosa ◽  
Matthew R Dressler ◽  
Shawn A Hunter
Keyword(s):  
Tissue Engineering ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Engineering Parameters

scholarly journals Functional Tissue Engineering of Ligament and Tendon Injuries

2008 ◽  
pp. 1206-1231 ◽  
Author(s):  
Savio L.-Y. Woo ◽  
Alejandro J. Almarza ◽  
Sinan Karaoglu ◽  
Steven D. Abramowitch
Keyword(s):  
Tissue Engineering ◽  
Tendon Injuries ◽  
Functional Tissue Engineering ◽  
Functional Tissue

The Role of Biomechanics in Functional Tissue Engineering for Articular Cartilage

2003 ◽  
pp. 37-60 ◽  
Author(s):  
X. Edward Guo ◽  
Helen H. Lu ◽  
Morakot Likhitpanichkul ◽  
Van C. Mow
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Functional tissue engineering of autologous tunica albuginea: A possible graft for peyronie's disease surgery

2003 ◽  
Vol 2 (1) ◽  
pp. 123
Author(s):  
D. Schultheiss ◽  
R.R. Lorenz ◽  
A.I. Gabouev ◽  
N. Schlote ◽  
J. Wefer ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Peyronie's Disease

Ligament Healing: Present Status and the Future of Functional Tissue Engineering

2006 ◽  
pp. 17-34 ◽  
Author(s):  
Savio L-Y. Woo ◽  
Steven D. Abramowitch ◽  
John C. Loh ◽  
Volker Musahl ◽  
James H-C. Wang
Keyword(s):  
Tissue Engineering ◽  
Present Status ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
The Future ◽  
Ligament Healing

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

2013 ◽  
Vol 19 (4) ◽  
pp. 353-367 ◽  
Author(s):  
Milena Fini ◽  
Stefania Pagani ◽  
Gianluca Giavaresi ◽  
Monica De Mattei ◽  
Alessia Ongaro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Functional Tissue Engineering: The Role of Biomechanics

2000 ◽  
Vol 122 (6) ◽  
pp. 570-575 ◽  
Author(s):  
David L. Butler ◽  
Steven A. Goldstein ◽  
Farshid Guilak
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physical Factors ◽  
Cellular Activity ◽  
Biosynthetic Activity ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Engineered Tissues

“Tissue engineering” uses implanted cells, scaffolds, DNA, protein, and/or protein fragments to replace or repair injured or diseased tissues and organs. Despite its early success, tissue engineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. An evolving discipline called “functional tissue engineering” (FTE) seeks to address these challenges. In this paper, the authors present principles of functional tissue engineering that should be addressed when engineering repairs and replacements for load-bearing structures. First, in vivo stress/strain histories need to be measured for a variety of activities. These in vivo data provide mechanical thresholds that tissue repairs/replacements will likely encounter after surgery. Second, the mechanical properties of the native tissues must be established for subfailure and failure conditions. These “baseline data” provide parameters within the expected thresholds for different in vivo activities and beyond these levels if safety factors are to be incorporated. Third, a subset of these mechanical properties must be selected and prioritized. This subset is important, given that the mechanical properties of the designs are not expected to completely duplicate the properties of the native tissues. Fourth, standards must be set when evaluating the repairs/replacements after surgery so as to determine, “how good is good enough?” Some aspects of the repair outcome may be inferior, but other mechanical characteristics of the repairs and replacements might be suitable. New and improved methods must also be developed for assessing the function of engineered tissues. Fifth, the effects of physical factors on cellular activity must be determined in engineered tissues. Knowing these signals may shorten the iterations required to replace a tissue successfully and direct cellular activity and phenotype toward a desired end goal. Finally, to effect a better repair outcome, cell-matrix implants may benefit from being mechanically stimulated using in vitro “bioreactors” prior to implantation. Increasing evidence suggests that mechanical stress, as well as other physical factors, may significantly increase the biosynthetic activity of cells in bioartificial matrices. Incorporating each of these principles of functional tissue engineering should result in safer and more efficacious repairs and replacements for the surgeon and patient. [S0148-0731(00)00206-5]

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